Human herpesvirus 8 DNA sequences are present in bone marrow from HIV‐negative patients with lymphoproliferative disorders and from healthy donors
Bone marrow (BM) from patients affected by multiple myeloma (MM), exhibiting monoclonal gammopathy of undetermined significance (MGUS) or with non‐Hodgkin lymphoma (NHL) as well as from healthy donors were investigated for the presence of human herpesvirus‐8 (HHV‐8) DNA sequences. ORF 26 sequences w...
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| Veröffentlicht in: | British journal of haematology 2001-04, Vol.113 (1), p.188-190 |
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| container_title | British journal of haematology |
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| creator | Azzi, A. Fanci, R. De Santis, R. Ciappi, S. Paci, C. |
| description | Bone marrow (BM) from patients affected by multiple myeloma (MM), exhibiting monoclonal gammopathy of undetermined significance (MGUS) or with non‐Hodgkin lymphoma (NHL) as well as from healthy donors were investigated for the presence of human herpesvirus‐8 (HHV‐8) DNA sequences. ORF 26 sequences were detected in 36–56% of the patients and in 29% of the controls. In a few cases, two other HHV‐8 DNA sequences were also detected. These observations indicate that the presence of the HHV‐8 genome in BM is relatively common in different groups of patients as well as in healthy individuals and do not support an alleged role for HHV‐8 in MM. |
| doi_str_mv | 10.1046/j.1365-2141.2001.02702.x |
| format | Article |
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ORF 26 sequences were detected in 36–56% of the patients and in 29% of the controls. In a few cases, two other HHV‐8 DNA sequences were also detected. These observations indicate that the presence of the HHV‐8 genome in BM is relatively common in different groups of patients as well as in healthy individuals and do not support an alleged role for HHV‐8 in MM.</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1046/j.1365-2141.2001.02702.x</identifier><identifier>PMID: 11328300</identifier><identifier>CODEN: BJHEAL</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Biological and medical sciences ; Bone Marrow - virology ; Bone Marrow Cells - virology ; Case-Control Studies ; Cells, Cultured ; DNA, Viral - analysis ; Hematologic and hematopoietic diseases ; Herpesvirus 8, Human - genetics ; Humans ; Immunodeficiencies. Immunoglobulinopathies ; Immunoglobulinopathies ; Immunopathology ; Kaposi's sarcoma‐associated herpesvirus (KSHV) ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphoma, Non-Hodgkin - virology ; Lymphoproliferative Disorders - virology ; Medical sciences ; Middle Aged ; monoclonal gammopathy ; multiple myeloma ; Multiple Myeloma - virology ; non‐Hodgkin's lymphoma ; Paraproteinemias - virology ; viral persistence</subject><ispartof>British journal of haematology, 2001-04, Vol.113 (1), p.188-190</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4442-d3fd72670e7a810ad1b02aa2e1c9e71569ae5ca6fefcf576a031babbf95fc3e83</citedby><cites>FETCH-LOGICAL-c4442-d3fd72670e7a810ad1b02aa2e1c9e71569ae5ca6fefcf576a031babbf95fc3e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-2141.2001.02702.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-2141.2001.02702.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1030875$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11328300$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Azzi, A.</creatorcontrib><creatorcontrib>Fanci, R.</creatorcontrib><creatorcontrib>De Santis, R.</creatorcontrib><creatorcontrib>Ciappi, S.</creatorcontrib><creatorcontrib>Paci, C.</creatorcontrib><title>Human herpesvirus 8 DNA sequences are present in bone marrow from HIV‐negative patients with lymphoproliferative disorders and from healthy donors</title><title>British journal of haematology</title><addtitle>Br J Haematol</addtitle><description>Bone marrow (BM) from patients affected by multiple myeloma (MM), exhibiting monoclonal gammopathy of undetermined significance (MGUS) or with non‐Hodgkin lymphoma (NHL) as well as from healthy donors were investigated for the presence of human herpesvirus‐8 (HHV‐8) DNA sequences. ORF 26 sequences were detected in 36–56% of the patients and in 29% of the controls. In a few cases, two other HHV‐8 DNA sequences were also detected. These observations indicate that the presence of the HHV‐8 genome in BM is relatively common in different groups of patients as well as in healthy individuals and do not support an alleged role for HHV‐8 in MM.</description><subject>Biological and medical sciences</subject><subject>Bone Marrow - virology</subject><subject>Bone Marrow Cells - virology</subject><subject>Case-Control Studies</subject><subject>Cells, Cultured</subject><subject>DNA, Viral - analysis</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Herpesvirus 8, Human - genetics</subject><subject>Humans</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Kaposi's sarcoma‐associated herpesvirus (KSHV)</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphoma, Non-Hodgkin - virology</subject><subject>Lymphoproliferative Disorders - virology</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>monoclonal gammopathy</subject><subject>multiple myeloma</subject><subject>Multiple Myeloma - virology</subject><subject>non‐Hodgkin's lymphoma</subject><subject>Paraproteinemias - virology</subject><subject>viral persistence</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkb2O1DAUhS0EYoeFV0AuEF3CdZy_KSiWXWAWraABWstxrolHiR3sZGen4xEoeEKeBIeMgJLqWvJ3zrXPIYQySBnk5Yt9ynhZJBnLWZoBsBSyCrL07h7Z_Lm4TzYAUCVRUJ-RRyHsI8ihYA_JGWM8qznAhvzYzYO0tEM_Yrg1fg60plfvL2jArzNahYFKj3T0GNBO1FjaOIt0kN67A9XeDXR3_fnnt-8Wv8jJ3EY0jogGejBTR_vjMHZu9K43Gv1KtCY436KP1rZdPTqU_dQdaeus8-ExeaBlH_DJaZ6TT29ef7zcJTcf3l5fXtwkKs_zLGm5bqusrAArWTOQLWsgkzJDprZYsaLcSiyULDVqpYuqlMBZI5tGbwutONb8nDxffeP74m_DJAYTFPa9tOjmICqogW1zFsF6BZV3IXjUYvQmZnAUDMTSiNiLJXixBC-WRsTvRsRdlD497ZibAdu_wlMFEXh2AmRQstdeWmXCPws41FURsZcrdjA9Hv97v3j1brec-C_NYatW</recordid><startdate>200104</startdate><enddate>200104</enddate><creator>Azzi, A.</creator><creator>Fanci, R.</creator><creator>De Santis, R.</creator><creator>Ciappi, S.</creator><creator>Paci, C.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200104</creationdate><title>Human herpesvirus 8 DNA sequences are present in bone marrow from HIV‐negative patients with lymphoproliferative disorders and from healthy donors</title><author>Azzi, A. ; Fanci, R. ; De Santis, R. ; Ciappi, S. ; Paci, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4442-d3fd72670e7a810ad1b02aa2e1c9e71569ae5ca6fefcf576a031babbf95fc3e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Biological and medical sciences</topic><topic>Bone Marrow - virology</topic><topic>Bone Marrow Cells - virology</topic><topic>Case-Control Studies</topic><topic>Cells, Cultured</topic><topic>DNA, Viral - analysis</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Herpesvirus 8, Human - genetics</topic><topic>Humans</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Kaposi's sarcoma‐associated herpesvirus (KSHV)</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphoma, Non-Hodgkin - virology</topic><topic>Lymphoproliferative Disorders - virology</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>monoclonal gammopathy</topic><topic>multiple myeloma</topic><topic>Multiple Myeloma - virology</topic><topic>non‐Hodgkin's lymphoma</topic><topic>Paraproteinemias - virology</topic><topic>viral persistence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Azzi, A.</creatorcontrib><creatorcontrib>Fanci, R.</creatorcontrib><creatorcontrib>De Santis, R.</creatorcontrib><creatorcontrib>Ciappi, S.</creatorcontrib><creatorcontrib>Paci, C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Azzi, A.</au><au>Fanci, R.</au><au>De Santis, R.</au><au>Ciappi, S.</au><au>Paci, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human herpesvirus 8 DNA sequences are present in bone marrow from HIV‐negative patients with lymphoproliferative disorders and from healthy donors</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>2001-04</date><risdate>2001</risdate><volume>113</volume><issue>1</issue><spage>188</spage><epage>190</epage><pages>188-190</pages><issn>0007-1048</issn><eissn>1365-2141</eissn><coden>BJHEAL</coden><abstract>Bone marrow (BM) from patients affected by multiple myeloma (MM), exhibiting monoclonal gammopathy of undetermined significance (MGUS) or with non‐Hodgkin lymphoma (NHL) as well as from healthy donors were investigated for the presence of human herpesvirus‐8 (HHV‐8) DNA sequences. ORF 26 sequences were detected in 36–56% of the patients and in 29% of the controls. In a few cases, two other HHV‐8 DNA sequences were also detected. These observations indicate that the presence of the HHV‐8 genome in BM is relatively common in different groups of patients as well as in healthy individuals and do not support an alleged role for HHV‐8 in MM.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>11328300</pmid><doi>10.1046/j.1365-2141.2001.02702.x</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biological and medical sciences Bone Marrow - virology Bone Marrow Cells - virology Case-Control Studies Cells, Cultured DNA, Viral - analysis Hematologic and hematopoietic diseases Herpesvirus 8, Human - genetics Humans Immunodeficiencies. Immunoglobulinopathies Immunoglobulinopathies Immunopathology Kaposi's sarcoma‐associated herpesvirus (KSHV) Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, Non-Hodgkin - virology Lymphoproliferative Disorders - virology Medical sciences Middle Aged monoclonal gammopathy multiple myeloma Multiple Myeloma - virology non‐Hodgkin's lymphoma Paraproteinemias - virology viral persistence |
| title | Human herpesvirus 8 DNA sequences are present in bone marrow from HIV‐negative patients with lymphoproliferative disorders and from healthy donors |
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