Hybrid (BDBB) interferon-α: preformulation studies

A number of techniques, including RP-HPLC, HP-SEC and SDS-PAGE have been used in the delineation of degradative mechanisms of recombinant hybrid (BDBB) interferon-α (IFN-α) in the solution phase. Different degradation profiles are found according to medium pH. At pH 4.0 the major routes of degradati...

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Veröffentlicht in:	International journal of pharmaceutics 1999-10, Vol.187 (2), p.259-272
Hauptverfasser:	Allen, John D, Bentley, David, Stringer, Rowan A, Lowther, Nicholas
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Biological and medical sciences Chemistry, Pharmaceutical Degradation Drug Stability Edetic Acid - pharmacology General pharmacology Hydrogen-Ion Concentration Interferon Interferon-alpha - chemistry Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Preformulation Protein Recombinant Proteins - chemistry Solutions Stability
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