The G protein beta3 subunit 825T allele is a genetic marker for enhanced T cell response

The G protein beta3 subunit 825T allele is a genetic marker for enhanced T cell response

The G protein beta3 subunit (GNB3) 825T allele is predictive of enhanced Gi protein activation. Studying the influence of C825T allele status on cellular in vitro immune responses towards recall antigens and interleukin-2 stimulation we observed a 2-4-fold, significantly increased proliferation in h...

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Veröffentlicht in:FEBS letters 2001-04, Vol.495 (1-2), p.82-86
Hauptverfasser: Lindemann, M, Virchow, S, Ramann, F, Barsegian, V, Kreuzfelder, E, Siffert, W, Müller, N, Grosse-Wilde, H
Format: Artikel
Sprache:eng
Schlagworte:
Alleles
Antigens - pharmacology
Antigens, CD - metabolism
CD4 Lymphocyte Count
Cell Division - drug effects
Cell Division - immunology
Chemotaxis - drug effects
Female
Genetic Markers
Genotype
Heterotrimeric GTP-Binding Proteins - genetics
Heterozygote
Homozygote
Humans
Immunocompetence - genetics
Immunophenotyping
Interleukin-2 - pharmacology
Lymphocyte Activation - drug effects
Lymphocyte Activation - genetics
Lymphocyte Subsets - cytology
Lymphocyte Subsets - metabolism
Male
T-Lymphocytes - cytology
T-Lymphocytes - drug effects
T-Lymphocytes - immunology
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Zusammenfassung:The G protein beta3 subunit (GNB3) 825T allele is predictive of enhanced Gi protein activation. Studying the influence of C825T allele status on cellular in vitro immune responses towards recall antigens and interleukin-2 stimulation we observed a 2-4-fold, significantly increased proliferation in homozygous 825T (TT) vs. C825 allele (CC) carriers. Furthermore, lymphocyte chemotaxis and CD4(+) T cell counts of individuals with TT+TC genotypes were significantly enhanced compared to the CC genotype. In summary, it appears that C825T allele status is highly predictive of immunocompetence and could be a candidate gene in disorders associated with inadequate immune response.
ISSN:0014-5793