Positron Emission Tomography Using [18F] Fluorodeoxyglucose and [ 11C] L-Methionine to Metabolically Characterize Dysembryoplastic Neuroepithelial Tumors
Dysembryoplastic neuroepithelial tumors are unique and benign congenital tumors occurring frequently in children and adolescents. Differentiation from other low-grade tumors is important for management. Five patients with confirmed dysembryoplastic neuroepithelial tumors were studied with positron e...
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| Veröffentlicht in: | Journal of child neurology 1999-10, Vol.14 (10), p.673-677 |
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| container_title | Journal of child neurology |
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| creator | Kaplan, Allen M. Lawson, Michael A. Spataro, Joseph Bandy, Daniel J. Bonstelle, Charles T. Moss, S. David Manwaring, Kim H. Reiman, Eric M. |
| description | Dysembryoplastic neuroepithelial tumors are unique and benign congenital tumors occurring frequently in children and adolescents. Differentiation from other low-grade tumors is important for management. Five patients with confirmed dysembryoplastic neuroepithelial tumors were studied with positron emission tomography using glucose and protein metabolic uptake in an attempt to categorize these tumors metabolically. Functional brain mapping also was obtained to aid in operative management. Results of the study conclude that dysembryoplastic neuroepithelial tumors, although having similar neuroimgaing characteristics to other low-grade tumors, are distinguished by a unique metabolic profile. They are inactive tumors with no significant glucose or protein metabolic activity. The combination of preoperative positron emission tomographic metabolic studies with functional brain mapping allowed for prediction of tumor type, defined eloquent areas of cortical function, and improved approach and resection of the tumors with minimal risk of neurologic impairment. (J Child Neurol 1999;14:673-677). |
| doi_str_mv | 10.1177/088307389901401009 |
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David ; Manwaring, Kim H. ; Reiman, Eric M.</creator><creatorcontrib>Kaplan, Allen M. ; Lawson, Michael A. ; Spataro, Joseph ; Bandy, Daniel J. ; Bonstelle, Charles T. ; Moss, S. David ; Manwaring, Kim H. ; Reiman, Eric M.</creatorcontrib><description>Dysembryoplastic neuroepithelial tumors are unique and benign congenital tumors occurring frequently in children and adolescents. Differentiation from other low-grade tumors is important for management. Five patients with confirmed dysembryoplastic neuroepithelial tumors were studied with positron emission tomography using glucose and protein metabolic uptake in an attempt to categorize these tumors metabolically. Functional brain mapping also was obtained to aid in operative management. Results of the study conclude that dysembryoplastic neuroepithelial tumors, although having similar neuroimgaing characteristics to other low-grade tumors, are distinguished by a unique metabolic profile. They are inactive tumors with no significant glucose or protein metabolic activity. The combination of preoperative positron emission tomographic metabolic studies with functional brain mapping allowed for prediction of tumor type, defined eloquent areas of cortical function, and improved approach and resection of the tumors with minimal risk of neurologic impairment. (J Child Neurol 1999;14:673-677).</description><identifier>ISSN: 0883-0738</identifier><identifier>EISSN: 1708-8283</identifier><identifier>DOI: 10.1177/088307389901401009</identifier><identifier>PMID: 10511341</identifier><identifier>CODEN: JOCNEE</identifier><language>eng</language><publisher>Thousand Oaks, CA: SAGE Publications</publisher><subject>Adolescent ; Blood Glucose - metabolism ; Brain ; Brain - diagnostic imaging ; Brain Mapping ; Brain Neoplasms - diagnostic imaging ; Brain Neoplasms - surgery ; Cerebral Cortex - diagnostic imaging ; Cerebral Cortex - surgery ; Child ; Energy Metabolism - physiology ; Female ; Fluorodeoxyglucose F18 ; Grade 1 ; Humans ; Individualized Instruction ; Male ; Methionine ; Neoplasms, Neuroepithelial - diagnostic imaging ; Neoplasms, Neuroepithelial - surgery ; Nerve Tissue Proteins - metabolism ; Prognosis ; Radionuclide Imaging ; Seizures</subject><ispartof>Journal of child neurology, 1999-10, Vol.14 (10), p.673-677</ispartof><rights>Copyright Decker Periodicals, Inc. Oct 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c492t-4a5a2314910ff740ca94c3e6fed086c55732f49506f3799d5ac039f9a6cf7c813</citedby><cites>FETCH-LOGICAL-c492t-4a5a2314910ff740ca94c3e6fed086c55732f49506f3799d5ac039f9a6cf7c813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/088307389901401009$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/088307389901401009$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21800,27903,27904,43600,43601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10511341$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kaplan, Allen M.</creatorcontrib><creatorcontrib>Lawson, Michael A.</creatorcontrib><creatorcontrib>Spataro, Joseph</creatorcontrib><creatorcontrib>Bandy, Daniel J.</creatorcontrib><creatorcontrib>Bonstelle, Charles T.</creatorcontrib><creatorcontrib>Moss, S. David</creatorcontrib><creatorcontrib>Manwaring, Kim H.</creatorcontrib><creatorcontrib>Reiman, Eric M.</creatorcontrib><title>Positron Emission Tomography Using [18F] Fluorodeoxyglucose and [ 11C] L-Methionine to Metabolically Characterize Dysembryoplastic Neuroepithelial Tumors</title><title>Journal of child neurology</title><addtitle>J Child Neurol</addtitle><description>Dysembryoplastic neuroepithelial tumors are unique and benign congenital tumors occurring frequently in children and adolescents. Differentiation from other low-grade tumors is important for management. Five patients with confirmed dysembryoplastic neuroepithelial tumors were studied with positron emission tomography using glucose and protein metabolic uptake in an attempt to categorize these tumors metabolically. Functional brain mapping also was obtained to aid in operative management. Results of the study conclude that dysembryoplastic neuroepithelial tumors, although having similar neuroimgaing characteristics to other low-grade tumors, are distinguished by a unique metabolic profile. They are inactive tumors with no significant glucose or protein metabolic activity. The combination of preoperative positron emission tomographic metabolic studies with functional brain mapping allowed for prediction of tumor type, defined eloquent areas of cortical function, and improved approach and resection of the tumors with minimal risk of neurologic impairment. (J Child Neurol 1999;14:673-677).</description><subject>Adolescent</subject><subject>Blood Glucose - metabolism</subject><subject>Brain</subject><subject>Brain - diagnostic imaging</subject><subject>Brain Mapping</subject><subject>Brain Neoplasms - diagnostic imaging</subject><subject>Brain Neoplasms - surgery</subject><subject>Cerebral Cortex - diagnostic imaging</subject><subject>Cerebral Cortex - surgery</subject><subject>Child</subject><subject>Energy Metabolism - physiology</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18</subject><subject>Grade 1</subject><subject>Humans</subject><subject>Individualized Instruction</subject><subject>Male</subject><subject>Methionine</subject><subject>Neoplasms, Neuroepithelial - diagnostic imaging</subject><subject>Neoplasms, Neuroepithelial - surgery</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Prognosis</subject><subject>Radionuclide Imaging</subject><subject>Seizures</subject><issn>0883-0738</issn><issn>1708-8283</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkc2KFDEUhYMoTjv6Ai4kuHBXzr2V-kmW0k6PQvuz6FkNQ5FO3erOkKq0SRVYvsm8rWl6QFHQVW7gO-dyz2HsJcJbxLq-ACkF1EIqBVgAAqhHbIE1yEzmUjxmiyOQHYkz9izGOwCQpYKn7AyhRBQFLtj9Vx_tGPzAL3sbo03Dxvd-F_RhP_PraIcdv0G5uuUrN_ngW_Lf552bjI_E9dDyG464vOXr7BON-yS3A_HR8_TTW--s0c7NfLnXQZuRgv1B_P0cqd-G2R-cjqM1_DNNwdPBjntyVju-mXof4nP2pNMu0ouH95xdry43yw_Z-svVx-W7dWYKlY9ZoUudCywUQtfVBRitCiOo6qgFWZmyrEXeFaqEqhO1Um2pDQjVKV2ZrjYSxTl7c_I9BP9tojg2KQhDzumB_BSblGdKVqj_gjnmiFIewdd_gHd-CkM6oslzKKBCCQnKT5AJPsZAXXMIttdhbhCaY73N3_Um0asH52nbU_ub5NRnAi5OQNQ7-rX2H5Y_Aeskrps</recordid><startdate>19991001</startdate><enddate>19991001</enddate><creator>Kaplan, Allen M.</creator><creator>Lawson, Michael A.</creator><creator>Spataro, Joseph</creator><creator>Bandy, Daniel J.</creator><creator>Bonstelle, Charles T.</creator><creator>Moss, S. 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Five patients with confirmed dysembryoplastic neuroepithelial tumors were studied with positron emission tomography using glucose and protein metabolic uptake in an attempt to categorize these tumors metabolically. Functional brain mapping also was obtained to aid in operative management. Results of the study conclude that dysembryoplastic neuroepithelial tumors, although having similar neuroimgaing characteristics to other low-grade tumors, are distinguished by a unique metabolic profile. They are inactive tumors with no significant glucose or protein metabolic activity. The combination of preoperative positron emission tomographic metabolic studies with functional brain mapping allowed for prediction of tumor type, defined eloquent areas of cortical function, and improved approach and resection of the tumors with minimal risk of neurologic impairment. (J Child Neurol 1999;14:673-677).</abstract><cop>Thousand Oaks, CA</cop><pub>SAGE Publications</pub><pmid>10511341</pmid><doi>10.1177/088307389901401009</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Blood Glucose - metabolism Brain Brain - diagnostic imaging Brain Mapping Brain Neoplasms - diagnostic imaging Brain Neoplasms - surgery Cerebral Cortex - diagnostic imaging Cerebral Cortex - surgery Child Energy Metabolism - physiology Female Fluorodeoxyglucose F18 Grade 1 Humans Individualized Instruction Male Methionine Neoplasms, Neuroepithelial - diagnostic imaging Neoplasms, Neuroepithelial - surgery Nerve Tissue Proteins - metabolism Prognosis Radionuclide Imaging Seizures |
| title | Positron Emission Tomography Using [18F] Fluorodeoxyglucose and [ 11C] L-Methionine to Metabolically Characterize Dysembryoplastic Neuroepithelial Tumors |
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