Peroxisome proliferator‐activated receptor γ transcriptional regulation is involved in platelet‐derived growth factor–induced proliferation of human hepatic stellate cells

During liver injury, hepatic stellate cells (HSC) acquire a myofibroblast‐like phenotype associated with reduction of lipid droplets, increased collagen synthesis, and proliferation. Peroxisome proliferator‐activated receptor γ (PPARγ) regulates adipocyte differentiation and controls gene transcript...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2000-01, Vol.31 (1), p.101-108
Hauptverfasser:	Galli, Andrea, Crabb, David, Price, Donna, Ceni, Elisabetta, Salzano, Renata, Surrenti, Calogero, Casini, Alessandro
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell Differentiation Cell Division Cells, Cultured Digestive system Gene Expression Gene Expression Regulation Humans Investigative techniques, diagnostic techniques (general aspects) Liver - cytology Medical sciences Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Platelet-Derived Growth Factor - pharmacology Prostaglandin D2 - analogs & derivatives Prostaglandin D2 - pharmacology Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - physiology RNA, Messenger - metabolism Thiazoles - pharmacology Thiazolidinediones Transcription Factors - genetics Transcription Factors - physiology Transcription, Genetic Transfection
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