Efficacy of nonwoven fabric bioreactor immobilized with porcine hepatocytes for ex vivo xenogeneic perfusion treatment of liver failure in dogs
We have developed a new bioartificial liver bioreactor filled with porcine hepatocytes immobilized on polyester nonwoven fabric (NWF). In this study, we investigated the efficacy of our hybrid bioartificial liver system incorporating the NWF bioreactors and an immunoglobulin adsorbent column for per...
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| Veröffentlicht in: | Artificial organs 2001-04, Vol.25 (4), p.273-280 |
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| creator | Naruse, K Sakai, Y Lei, G Sakamoto, Y Kobayashi, T Puliatti, C Aronica, G Morale, W Leone, F Qiang, S Ming, S G Ming, S Li, Z Chang, S J Suzuki, M Makuuchi, M |
| description | We have developed a new bioartificial liver bioreactor filled with porcine hepatocytes immobilized on polyester nonwoven fabric (NWF). In this study, we investigated the efficacy of our hybrid bioartificial liver system incorporating the NWF bioreactors and an immunoglobulin adsorbent column for perfusion treatment in a canine liver failure model. Xenogeneic perfusion treatment for operative canine liver failure models were performed for 3 h, and survival time, intracranial pressure, and blood and cerebrospinal fluid data were documented. Treatment was carried out without obstruction by immunological rejection when immunoglobulin adsorbent columns were used with the NWF bioreactors in combination. Dogs treated with this system exhibited a restricted increase of intracranial pressure and significant compensatory effects on blood and cerebrospinal amino acid imbalances as shown by a significant improvement of Fischer's ratio. On the other hand, relatively low capacity for ammonia elimination was shown as compared with homologous direct hemoperfusion. |
| doi_str_mv | 10.1046/j.1525-1594.2001.025004273.x |
| format | Article |
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In this study, we investigated the efficacy of our hybrid bioartificial liver system incorporating the NWF bioreactors and an immunoglobulin adsorbent column for perfusion treatment in a canine liver failure model. Xenogeneic perfusion treatment for operative canine liver failure models were performed for 3 h, and survival time, intracranial pressure, and blood and cerebrospinal fluid data were documented. Treatment was carried out without obstruction by immunological rejection when immunoglobulin adsorbent columns were used with the NWF bioreactors in combination. Dogs treated with this system exhibited a restricted increase of intracranial pressure and significant compensatory effects on blood and cerebrospinal amino acid imbalances as shown by a significant improvement of Fischer's ratio. On the other hand, relatively low capacity for ammonia elimination was shown as compared with homologous direct hemoperfusion.</description><identifier>ISSN: 0160-564X</identifier><identifier>EISSN: 1525-1594</identifier><identifier>DOI: 10.1046/j.1525-1594.2001.025004273.x</identifier><identifier>PMID: 11318756</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Aspartate Aminotransferases - blood ; Bioreactors ; Blood Chemical Analysis ; Cells, Immobilized ; Cerebrospinal Fluid - chemistry ; Dogs ; Hemoperfusion - instrumentation ; Hepatocytes ; Immunosorbents ; Intracranial Pressure ; Liver Failure - metabolism ; Liver Failure - physiopathology ; Liver Failure - therapy ; Liver, Artificial ; Polyesters ; Swine</subject><ispartof>Artificial organs, 2001-04, Vol.25 (4), p.273-280</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-e853337673f2a97b6cd0a64e61114223d82995d2096f013d2425751df62bfbb63</citedby><cites>FETCH-LOGICAL-c319t-e853337673f2a97b6cd0a64e61114223d82995d2096f013d2425751df62bfbb63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11318756$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Naruse, K</creatorcontrib><creatorcontrib>Sakai, Y</creatorcontrib><creatorcontrib>Lei, G</creatorcontrib><creatorcontrib>Sakamoto, Y</creatorcontrib><creatorcontrib>Kobayashi, T</creatorcontrib><creatorcontrib>Puliatti, C</creatorcontrib><creatorcontrib>Aronica, G</creatorcontrib><creatorcontrib>Morale, W</creatorcontrib><creatorcontrib>Leone, F</creatorcontrib><creatorcontrib>Qiang, S</creatorcontrib><creatorcontrib>Ming, S G</creatorcontrib><creatorcontrib>Ming, S</creatorcontrib><creatorcontrib>Li, Z</creatorcontrib><creatorcontrib>Chang, S J</creatorcontrib><creatorcontrib>Suzuki, M</creatorcontrib><creatorcontrib>Makuuchi, M</creatorcontrib><title>Efficacy of nonwoven fabric bioreactor immobilized with porcine hepatocytes for ex vivo xenogeneic perfusion treatment of liver failure in dogs</title><title>Artificial organs</title><addtitle>Artif Organs</addtitle><description>We have developed a new bioartificial liver bioreactor filled with porcine hepatocytes immobilized on polyester nonwoven fabric (NWF). In this study, we investigated the efficacy of our hybrid bioartificial liver system incorporating the NWF bioreactors and an immunoglobulin adsorbent column for perfusion treatment in a canine liver failure model. Xenogeneic perfusion treatment for operative canine liver failure models were performed for 3 h, and survival time, intracranial pressure, and blood and cerebrospinal fluid data were documented. Treatment was carried out without obstruction by immunological rejection when immunoglobulin adsorbent columns were used with the NWF bioreactors in combination. Dogs treated with this system exhibited a restricted increase of intracranial pressure and significant compensatory effects on blood and cerebrospinal amino acid imbalances as shown by a significant improvement of Fischer's ratio. On the other hand, relatively low capacity for ammonia elimination was shown as compared with homologous direct hemoperfusion.</description><subject>Animals</subject><subject>Aspartate Aminotransferases - blood</subject><subject>Bioreactors</subject><subject>Blood Chemical Analysis</subject><subject>Cells, Immobilized</subject><subject>Cerebrospinal Fluid - chemistry</subject><subject>Dogs</subject><subject>Hemoperfusion - instrumentation</subject><subject>Hepatocytes</subject><subject>Immunosorbents</subject><subject>Intracranial Pressure</subject><subject>Liver Failure - metabolism</subject><subject>Liver Failure - physiopathology</subject><subject>Liver Failure - therapy</subject><subject>Liver, Artificial</subject><subject>Polyesters</subject><subject>Swine</subject><issn>0160-564X</issn><issn>1525-1594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkctq3DAUhkVpaCZpX6FoUbqzo7vG0E0JaRsIdNNCd0KWjxINtuRK9mSmL5FXrk2GZHUW57_A_yH0iZKaEqGudjWVTFZUNqJmhNCaMEmIYJrXhzdo8_J8izaEKlJJJf6co4tSdoQQLYh6h84p5XSrpdqgpxvvg7PuiJPHMcXHtIeIvW1zcLgNKYN1U8o4DENqQx_-QYcfw_SAx5RdiIAfYLRTcscJCvaLEA54H_YJHyCme4iwxIyQ_VxCinha4qYB4rS29WEPeakK_ZwBh4i7dF_eozNv-wIfTvcS_f528-v6R3X38_vt9de7ynHaTBVsJedcK809s41uleuIVQIUpVQwxrstaxrZMdIoTyjvmGBSS9p5xVrftopfos_PuWNOf2cokxlCcdD3NkKai9FEN7rhYhF-eRa6nErJ4M2Yw2Dz0VBiViBmZ9bNzbq5WYGYFyDmsNg_nnrmdoDu1XwiwP8DNPeKpw</recordid><startdate>20010401</startdate><enddate>20010401</enddate><creator>Naruse, K</creator><creator>Sakai, Y</creator><creator>Lei, G</creator><creator>Sakamoto, Y</creator><creator>Kobayashi, T</creator><creator>Puliatti, C</creator><creator>Aronica, G</creator><creator>Morale, W</creator><creator>Leone, F</creator><creator>Qiang, S</creator><creator>Ming, S G</creator><creator>Ming, S</creator><creator>Li, Z</creator><creator>Chang, S J</creator><creator>Suzuki, M</creator><creator>Makuuchi, M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010401</creationdate><title>Efficacy of nonwoven fabric bioreactor immobilized with porcine hepatocytes for ex vivo xenogeneic perfusion treatment of liver failure in dogs</title><author>Naruse, K ; Sakai, Y ; Lei, G ; Sakamoto, Y ; Kobayashi, T ; Puliatti, C ; Aronica, G ; Morale, W ; Leone, F ; Qiang, S ; Ming, S G ; Ming, S ; Li, Z ; Chang, S J ; Suzuki, M ; Makuuchi, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-e853337673f2a97b6cd0a64e61114223d82995d2096f013d2425751df62bfbb63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Aspartate Aminotransferases - blood</topic><topic>Bioreactors</topic><topic>Blood Chemical Analysis</topic><topic>Cells, Immobilized</topic><topic>Cerebrospinal Fluid - chemistry</topic><topic>Dogs</topic><topic>Hemoperfusion - instrumentation</topic><topic>Hepatocytes</topic><topic>Immunosorbents</topic><topic>Intracranial Pressure</topic><topic>Liver Failure - metabolism</topic><topic>Liver Failure - physiopathology</topic><topic>Liver Failure - therapy</topic><topic>Liver, Artificial</topic><topic>Polyesters</topic><topic>Swine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Naruse, K</creatorcontrib><creatorcontrib>Sakai, Y</creatorcontrib><creatorcontrib>Lei, G</creatorcontrib><creatorcontrib>Sakamoto, Y</creatorcontrib><creatorcontrib>Kobayashi, T</creatorcontrib><creatorcontrib>Puliatti, C</creatorcontrib><creatorcontrib>Aronica, G</creatorcontrib><creatorcontrib>Morale, W</creatorcontrib><creatorcontrib>Leone, F</creatorcontrib><creatorcontrib>Qiang, S</creatorcontrib><creatorcontrib>Ming, S G</creatorcontrib><creatorcontrib>Ming, S</creatorcontrib><creatorcontrib>Li, Z</creatorcontrib><creatorcontrib>Chang, S J</creatorcontrib><creatorcontrib>Suzuki, M</creatorcontrib><creatorcontrib>Makuuchi, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Artificial organs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Naruse, K</au><au>Sakai, Y</au><au>Lei, G</au><au>Sakamoto, Y</au><au>Kobayashi, T</au><au>Puliatti, C</au><au>Aronica, G</au><au>Morale, W</au><au>Leone, F</au><au>Qiang, S</au><au>Ming, S G</au><au>Ming, S</au><au>Li, Z</au><au>Chang, S J</au><au>Suzuki, M</au><au>Makuuchi, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of nonwoven fabric bioreactor immobilized with porcine hepatocytes for ex vivo xenogeneic perfusion treatment of liver failure in dogs</atitle><jtitle>Artificial organs</jtitle><addtitle>Artif Organs</addtitle><date>2001-04-01</date><risdate>2001</risdate><volume>25</volume><issue>4</issue><spage>273</spage><epage>280</epage><pages>273-280</pages><issn>0160-564X</issn><eissn>1525-1594</eissn><abstract>We have developed a new bioartificial liver bioreactor filled with porcine hepatocytes immobilized on polyester nonwoven fabric (NWF). In this study, we investigated the efficacy of our hybrid bioartificial liver system incorporating the NWF bioreactors and an immunoglobulin adsorbent column for perfusion treatment in a canine liver failure model. Xenogeneic perfusion treatment for operative canine liver failure models were performed for 3 h, and survival time, intracranial pressure, and blood and cerebrospinal fluid data were documented. Treatment was carried out without obstruction by immunological rejection when immunoglobulin adsorbent columns were used with the NWF bioreactors in combination. Dogs treated with this system exhibited a restricted increase of intracranial pressure and significant compensatory effects on blood and cerebrospinal amino acid imbalances as shown by a significant improvement of Fischer's ratio. On the other hand, relatively low capacity for ammonia elimination was shown as compared with homologous direct hemoperfusion.</abstract><cop>United States</cop><pmid>11318756</pmid><doi>10.1046/j.1525-1594.2001.025004273.x</doi><tpages>8</tpages></addata></record> |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Animals Aspartate Aminotransferases - blood Bioreactors Blood Chemical Analysis Cells, Immobilized Cerebrospinal Fluid - chemistry Dogs Hemoperfusion - instrumentation Hepatocytes Immunosorbents Intracranial Pressure Liver Failure - metabolism Liver Failure - physiopathology Liver Failure - therapy Liver, Artificial Polyesters Swine |
| title | Efficacy of nonwoven fabric bioreactor immobilized with porcine hepatocytes for ex vivo xenogeneic perfusion treatment of liver failure in dogs |
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