The CaMKII UNC-43 Activates the MAPKKK NSY-1 to Execute a Lateral Signaling Decision Required for Asymmetric Olfactory Neuron Fates

A stochastic cell fate decision mediated by axon contact and calcium signaling causes one of the two bilaterally symmetric AWC neurons, either AWCL or AWCR, to express the candidate olfactory receptor str-2. nsy-1 mutants express str-2 in both neurons, disrupting AWC asymmetry. nsy-1 encodes a homol...

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Veröffentlicht in:	Cell 2001-04, Vol.105 (2), p.221-232
Hauptverfasser:	Sagasti, Alvaro, Hisamoto, Naoki, Hyodo, Junko, Tanaka-Hino, Miho, Matsumoto, Kunihiro, Bargmann, Cornelia I
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Caenorhabditis elegans - cytology Caenorhabditis elegans - embryology Caenorhabditis elegans - genetics Caenorhabditis elegans Proteins Calcium-Calmodulin-Dependent Protein Kinase Type 2 Calcium-Calmodulin-Dependent Protein Kinases - metabolism Cell Line Epistasis, Genetic Gene Targeting Genes, Reporter - genetics Humans Immunoblotting MAP Kinase Kinase Kinases - genetics MAP Kinase Kinase Kinases - metabolism MAP Kinase Signaling System - genetics MAP Kinase Signaling System - physiology Microscopy, Confocal Molecular Sequence Data Mosaicism - genetics Olfactory Receptor Neurons - physiology Phosphorylation Receptors, Odorant - genetics Receptors, Odorant - metabolism Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Sequence Alignment Transgenes - genetics
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