Characterisation of the influence of micronisation on the crystallinity and physical stability of revatropate hydrobromide

Micronised particles of revatropate hydrobromide were observed to agglomerate when stored in uncontrolled conditions. Dynamic vapour sorption (DVS), isothermal microcalorimetry, microscopy and particle size measurement by laser diffraction have been used to study micronised revatropate hydrobromide....

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Veröffentlicht in:	International journal of pharmaceutics 2000-01, Vol.193 (2), p.247-259
Hauptverfasser:	D. Ticehurst, Martyn, A. Basford, Patricia, I. Dallman, Christopher, M. Lukas, Timothy, V. Marshall, Peter, Nichols, Gary, Smith, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Adsorption Agglomeration Biological and medical sciences Calorimetry Chemical Phenomena Chemistry, Physical Crystallinity Crystallization Drug Compounding Drug Stability Dynamic vapour sorption General pharmacology Humidity Medical sciences Microcalorimetry Micronisation Microscopy, Electron, Scanning Muscarinic Antagonists - administration & dosage Muscarinic Antagonists - chemistry Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Powders Quinuclidines - administration & dosage Quinuclidines - chemistry Respiratory system Water - chemistry X-Ray Diffraction
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