Increased Complement Biosynthesis By Microglia and Complement Activation on Neurons in Huntington's Disease

In this study complement activation and biosynthesis have been analysed in the brains of Huntington's disease (HD) (n=9) and normal (n=3) individuals. In HD striatum, neurons, myelin and astrocytes were strongly stained with antibodies to C1q, C4, C3, iC3b-neoepitope and C9-neoepitope. In contr...

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Veröffentlicht in:	Experimental neurology 1999-10, Vol.159 (2), p.362-376
Hauptverfasser:	Singhrao, S.K, Neal, J.W, Morgan, B.P, Gasque, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Astrocytes - immunology Biological and medical sciences Brain - immunology Brain - pathology Complement Activation Complement System Proteins - biosynthesis Complement System Proteins - genetics Corpus Striatum - immunology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases DNA Primers Gene Expression Regulation - immunology Gliosis Humans Huntington Disease - genetics Huntington Disease - immunology Huntington Disease - pathology Medical sciences Microglia - immunology Middle Aged Myelin Sheath - immunology Neurology Neurons - immunology Reference Values Reverse Transcriptase Polymerase Chain Reaction
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