The potential importance of HIV-induction of lymphocyte homing to lymph nodes
The mechanism by which HIV causes depletion of CD4 lymphocytes remains unknown. Recent studies have demonstrated that HIV binding to resting CD4 lymphocytes causes them to home from the blood into lymph node, and during the homing process, they are induced into apoptosis only to secondary signals th...
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| Veröffentlicht in: | International immunology 1999-10, Vol.11 (10), p.1591-1594 |
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| container_title | International immunology |
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| creator | Chen, Jenny J.-Y. Cloyd, Miles W. |
| description | The mechanism by which HIV causes depletion of CD4 lymphocytes remains unknown. Recent studies have demonstrated that HIV binding to resting CD4 lymphocytes causes them to home from the blood into lymph node, and during the homing process, they are induced into apoptosis only to secondary signals through the homing receptors. If this is the principal mechanism of CD4 cell depletion, it can explain many of the events known to occur in HIV-infected individual. |
| doi_str_mv | 10.1093/intimm/11.10.1591 |
| format | Article |
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| ispartof | International immunology, 1999-10, Vol.11 (10), p.1591-1594 |
| issn | 0953-8178 1460-2377 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | AIDS AIDS/HIV Apoptosis - immunology CD4 antigen Cell Adhesion - immunology HIV HIV - immunology HIV - physiology HIV Infections - immunology HIV Infections - virology homing Human immunodeficiency virus Humans Immunity, Cellular lymph nodes Lymph Nodes - immunology Lymph Nodes - physiology Lymph Nodes - virology lymphocytes |
| title | The potential importance of HIV-induction of lymphocyte homing to lymph nodes |
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