Genetic prodrug activation therapy (GPAT) in two rat prostate models generates an immune bystander effect and can be monitored by magnetic resonance techniques

Treatment of hormone refractory prostate cancer requires new treatment strategies. Genetic prodrug activation therapy (GPAT) may provide a new therapeutic avenue. In this study the antitumour efficacy of the gene encoding herpes simplex virus thymidine kinase (HSVtk) activating the prodrug ganciclov...

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Veröffentlicht in:	Gene therapy 2001-04, Vol.8 (7), p.557-567
Hauptverfasser:	EATON, J. D, PERRY, M. J. A, TODRYK, S. M, MAZUCCO, R. A, KIRBY, R. S, GRIFFITHS, J. R, DALGLEISH, A. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Annexin V Apoptosis Biological and medical sciences Biotechnology Cell activation Cell death Cell Survival Disease Models, Animal Energy balance Enzyme Activation - genetics Fundamental and applied biological sciences. Psychology g-Interferon Ganciclovir Ganciclovir - metabolism Ganciclovir - therapeutic use Gene therapy Genetic Therapy - methods Health. Pharmaceutical industry Herpes simplex herpes simplex virus Immune response Immunogenicity Immunotherapy Industrial applications and implications. Economical aspects Lymphocytes T Magnetic Resonance Spectroscopy Male Metastases Neoplasm Metastasis Neoplasm Transplantation Patients Prodrugs Prodrugs - metabolism Prodrugs - therapeutic use Prostate cancer Prostatic Neoplasms - immunology Prostatic Neoplasms - pathology Prostatic Neoplasms - therapy Rats Splenocytes Th1 Cells - immunology Thymidine Thymidine kinase Thymidine Kinase - genetics Transfection Tumor cell lines Tumor Cells, Cultured Tumors γ-Interferon
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