Dimeric l-Dopa Derivatives as Potential Prodrugs

A series of dimeric derivatives (+)- 1, and (+)- 2, and (+)- 3a–d of l-Dopa diacetyl esters was synthesized and evaluated as potential l-Dopa prodrugs with improved physicochemical properties. All the new compounds showed chemical stability in aqueous buffer solutions (pH 1.3 and 7.4). A relatively...

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Veröffentlicht in:Bioorganic & medicinal chemistry letters 2001-04, Vol.11 (8), p.1085-1088
Hauptverfasser: Di Stefano, Antonio, Mosciatti, Barbara, Mario Cingolani, Gian, Giorgioni, Gianfabio, Ricciutelli, Massimo, Cacciatore, Ivana, Sozio, Piera, Claudi, Francesco
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Sprache:eng
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