Analysis of Loss of Adhesive Function in Sperm Lacking Cyritestin or Fertilin β

We produced mice lacking the sperm surface protein cyritestin (ADAM 3) and found mutant males are infertile. Similar to fertilin beta (ADAM 2) null sperm (C. Cho et al., 1998, Science 281, 1857–1859), cyritestin null sperm are drastically deficient in adhesion to the egg zona pellucida (0.3% of wild...

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Veröffentlicht in:	Developmental biology 2001-05, Vol.233 (1), p.204-213
Hauptverfasser:	Nishimura, Hitoshi, Cho, Chunghee, Branciforte, Daniel R., Myles, Diana G., Primakoff, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM ADAM Proteins Animals Cell Adhesion Female Fertilins fertilization Infertility, Male Male Membrane Glycoproteins - analysis Membrane Glycoproteins - deficiency Membrane Microdomains - chemistry Metalloendopeptidases - analysis Metalloendopeptidases - deficiency Mice Mice, Knockout microdomain Protein Precursors - analysis Sperm-Ovum Interactions sperm-zona binding Spermatozoa - physiology sperm–egg fusion Testis - chemistry Zona Pellucida
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