Role of renocortical cyclooxygenase-2 for renal vascular resistance and macula densa control of renin secretion

This study aimed to assess the role of cyclooxygenase-2 (COX-2)-derived prostanoids for the macula densa control of renal afferent arteriolar resistance and for renin secretion. For this purpose, studied were the effects of blocking macula densa salt transport by the loop diuretic bumetanide (100 mi...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2001-05, Vol.12 (5), p.867-874
Hauptverfasser:	CASTROP, Hayo, SCHWEDA, Frank, SCHUMACHER, Karl, WOLF, Konrad, KURTZ, Armin
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin-Converting Enzyme Inhibitors - pharmacology Animals Biological and medical sciences Bumetanide - pharmacology Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors - pharmacology Diet, Sodium-Restricted Diuretics - pharmacology In Vitro Techniques Investigative techniques of renal and urinary tract function Investigative techniques, diagnostic techniques (general aspects) Isoenzymes - antagonists & inhibitors Isoenzymes - genetics Isoenzymes - metabolism Kidney Cortex - drug effects Kidney Cortex - enzymology Kidney Cortex - metabolism Male Medical sciences Nitrobenzenes - pharmacology Prostaglandin-Endoperoxide Synthases - genetics Prostaglandin-Endoperoxide Synthases - metabolism Ramipril - pharmacology Rats Rats, Sprague-Dawley Renal Circulation - physiology Renin - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Sulfonamides - pharmacology Vascular Resistance - physiology
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