Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-3 Are Key Regulators of Extracellular Matrix Degradation by Mouse Embryos

Embryo implantation in humans and rodents is a highly invasive yet tightly controlled process involving extracellular matrix (ECM) degradation. Matrix metalloproteinase 9 (MMP-9) has been implicated as the major facilitator of this ECM degradation. MMP-9 is expressed by the embryo's trophoblast...

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Veröffentlicht in:	Biology of reproduction 2001-05, Vol.64 (5), p.1331-1337
Hauptverfasser:	WHITESIDE, Eliza J, JACKSON, Michael M, HERINGTON, Adrian C, EDWARDS, Dylan R, HARVEY, Mark B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blastocyst - physiology Blastocyst - ultrastructure Cell Line Cricetinae Culture Media, Conditioned Culture Techniques Early stages. Segmentation. Gastrulation. Neurulation Embryo Implantation Embryo, Mammalian - physiology Embryo, Mammalian - ultrastructure Embryology: invertebrates and vertebrates. Teratology Enzyme Inhibitors Extracellular Matrix - metabolism Fundamental and applied biological sciences. Psychology Kidney Matrix Metalloproteinase 9 - physiology Matrix Metalloproteinase Inhibitors Mice Oligonucleotides - pharmacology Oligonucleotides, Antisense - pharmacology Tissue Inhibitor of Metalloproteinase-3 - physiology
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