Percutaneous penetration enhancement activity of aromatic S, S-dimethyliminosulfuranes

The activity of three series of iminosulfuranes (classes I–III) as potential transdermal penetration enhancers was investigated. These dimethyl sulfoxide (DMSO) related compounds were synthesized from activated DMSO by trifluoroacetic anhydride. Structure confirmation was accomplished by 1H NMR, and...

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Veröffentlicht in:	International journal of pharmaceutics 1999-10, Vol.187 (2), p.219-229
Hauptverfasser:	Kim, N., El-Khalili, M., Henary, M.M., Strekowski, L., Michniak, B.B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dimethyl Sulfoxide - analogs & derivatives Dimethyl Sulfoxide - pharmacology Enhancers Hairless mouse skin Hydrocortisone Hydrocortisone - pharmacokinetics Male Mice Mice, Hairless Percutaneous absorption Retardants Skin Absorption - drug effects Structure-Activity Relationship
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