Effects of the lipophilic biscation, bis-Pyridinium oxime BP12, on bioenergetics and induction of permeability transition in isolated mitochondria

In order to further investigate the mechanism of action of bridged lipophilic bis-pyridinium oximes previously observed to interfere with mitochondrial metabolism and to induce growth arrest and apoptosis in HeLa cells (Nocentini et al., Biochem Pharmacol 53: 1543–1552, 1997), we studied the effects...

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