Clinical significance of TT virus infection in patients with chronic liver disease and volunteer blood donors in Egypt
Clinical significance of TT virus (TTV) infection was investigated in Egyptian patients with chronic liver disease and volunteer blood donors by a cross sectional analysis. TTV DNA in serum was assessed by a semi‐nested polymerase chain reaction. The prevalence of TTV DNA did not differ among patien...
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| Veröffentlicht in: | Journal of medical virology 2000-02, Vol.60 (2), p.177-181 |
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| creator | Gad, Amal Tanaka, Eiji Orii, Kohji Kafumi, Todoriki Serwah, Abed El-Hamid El-Sherif, Asem Nooman, Zohair Kiyosawa, Kendo |
| description | Clinical significance of TT virus (TTV) infection was investigated in Egyptian patients with chronic liver disease and volunteer blood donors by a cross sectional analysis. TTV DNA in serum was assessed by a semi‐nested polymerase chain reaction. The prevalence of TTV DNA did not differ among patients with chronic hepatitis B (11/24, 46%), chronic hepatitis C (22/72, 31%), or schistosomal liver disease (14/39, 36%). No difference in prevalence was found between blood donors (32/109, 29%) and each of the patient groups. Clinical background including mean age, sex distribution, history of blood transfusion, and mean level of alanine aminotransferase did not differ between TTV DNA‐positive and ‐negative individuals in any of the study groups. Ultrasonographic evidence of liver cirrhosis was similar between TTV‐positive and ‐negative patients in each of the chronic liver disease groups. TTV infection was not associated with hepatitis B or C virus infection in blood donors. The only significant difference observed was the lower concentration of serum HCV RNA in TTV DNA positive compared with negative patients with chronic hepatitis C (3.0 ± 1.4 vs. 4.0 ± 0.9 log copies/ml, P < .001). In conclusion, TTV infection was not associated with either past history of blood exposure or infection with bloodborne hepatitis viruses in Egypt. No clinical significance of TTV was found in the present study. However, a reciprocal interaction was suggested between TTV and HCV replication. J. Med. Virol. 60:177–181, 2000. © 2000 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/(SICI)1096-9071(200002)60:2<177::AID-JMV12>3.0.CO;2-Z |
| format | Article |
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TTV DNA in serum was assessed by a semi‐nested polymerase chain reaction. The prevalence of TTV DNA did not differ among patients with chronic hepatitis B (11/24, 46%), chronic hepatitis C (22/72, 31%), or schistosomal liver disease (14/39, 36%). No difference in prevalence was found between blood donors (32/109, 29%) and each of the patient groups. Clinical background including mean age, sex distribution, history of blood transfusion, and mean level of alanine aminotransferase did not differ between TTV DNA‐positive and ‐negative individuals in any of the study groups. Ultrasonographic evidence of liver cirrhosis was similar between TTV‐positive and ‐negative patients in each of the chronic liver disease groups. TTV infection was not associated with hepatitis B or C virus infection in blood donors. The only significant difference observed was the lower concentration of serum HCV RNA in TTV DNA positive compared with negative patients with chronic hepatitis C (3.0 ± 1.4 vs. 4.0 ± 0.9 log copies/ml, P < .001). In conclusion, TTV infection was not associated with either past history of blood exposure or infection with bloodborne hepatitis viruses in Egypt. No clinical significance of TTV was found in the present study. However, a reciprocal interaction was suggested between TTV and HCV replication. J. Med. Virol. 60:177–181, 2000. © 2000 Wiley‐Liss, Inc.</description><identifier>ISSN: 0146-6615</identifier><identifier>EISSN: 1096-9071</identifier><identifier>DOI: 10.1002/(SICI)1096-9071(200002)60:2<177::AID-JMV12>3.0.CO;2-Z</identifier><identifier>PMID: 10596018</identifier><identifier>CODEN: JMVIDB</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Blood Donors ; Chronic Disease ; chronic hepatitis ; DNA, Viral - blood ; Egypt - epidemiology ; Epidemiology ; Female ; Fundamental and applied biological sciences. Psychology ; Hepatitis - epidemiology ; Hepatitis - virology ; hepatitis B virus ; Hepatitis B, Chronic - virology ; hepatitis C virus ; Hepatitis C, Chronic - virology ; Hepatitis Viruses - genetics ; Human viral diseases ; Humans ; Infectious diseases ; Liver Diseases - virology ; Male ; Medical sciences ; Microbiology ; Middle Aged ; Polymerase Chain Reaction ; Schistosomiasis - virology ; Seroepidemiologic Studies ; Viral diseases ; Viral hepatitis ; Virology ; Volunteers</subject><ispartof>Journal of medical virology, 2000-02, Vol.60 (2), p.177-181</ispartof><rights>Copyright © 2000 Wiley‐Liss, Inc.</rights><rights>2000 INIST-CNRS</rights><rights>Copyright 2000 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3462-a7e3a6459260ece4753e58409ae88caa69a6db6fee54c97b84299f43cc1fc3f63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291096-9071%28200002%2960%3A2%3C177%3A%3AAID-JMV12%3E3.0.CO%3B2-Z$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291096-9071%28200002%2960%3A2%3C177%3A%3AAID-JMV12%3E3.0.CO%3B2-Z$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1255743$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10596018$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gad, Amal</creatorcontrib><creatorcontrib>Tanaka, Eiji</creatorcontrib><creatorcontrib>Orii, Kohji</creatorcontrib><creatorcontrib>Kafumi, Todoriki</creatorcontrib><creatorcontrib>Serwah, Abed El-Hamid</creatorcontrib><creatorcontrib>El-Sherif, Asem</creatorcontrib><creatorcontrib>Nooman, Zohair</creatorcontrib><creatorcontrib>Kiyosawa, Kendo</creatorcontrib><title>Clinical significance of TT virus infection in patients with chronic liver disease and volunteer blood donors in Egypt</title><title>Journal of medical virology</title><addtitle>J. Med. Virol</addtitle><description>Clinical significance of TT virus (TTV) infection was investigated in Egyptian patients with chronic liver disease and volunteer blood donors by a cross sectional analysis. TTV DNA in serum was assessed by a semi‐nested polymerase chain reaction. The prevalence of TTV DNA did not differ among patients with chronic hepatitis B (11/24, 46%), chronic hepatitis C (22/72, 31%), or schistosomal liver disease (14/39, 36%). No difference in prevalence was found between blood donors (32/109, 29%) and each of the patient groups. Clinical background including mean age, sex distribution, history of blood transfusion, and mean level of alanine aminotransferase did not differ between TTV DNA‐positive and ‐negative individuals in any of the study groups. Ultrasonographic evidence of liver cirrhosis was similar between TTV‐positive and ‐negative patients in each of the chronic liver disease groups. TTV infection was not associated with hepatitis B or C virus infection in blood donors. The only significant difference observed was the lower concentration of serum HCV RNA in TTV DNA positive compared with negative patients with chronic hepatitis C (3.0 ± 1.4 vs. 4.0 ± 0.9 log copies/ml, P < .001). In conclusion, TTV infection was not associated with either past history of blood exposure or infection with bloodborne hepatitis viruses in Egypt. No clinical significance of TTV was found in the present study. However, a reciprocal interaction was suggested between TTV and HCV replication. J. Med. Virol. 60:177–181, 2000. © 2000 Wiley‐Liss, Inc.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Blood Donors</subject><subject>Chronic Disease</subject><subject>chronic hepatitis</subject><subject>DNA, Viral - blood</subject><subject>Egypt - epidemiology</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hepatitis - epidemiology</subject><subject>Hepatitis - virology</subject><subject>hepatitis B virus</subject><subject>Hepatitis B, Chronic - virology</subject><subject>hepatitis C virus</subject><subject>Hepatitis C, Chronic - virology</subject><subject>Hepatitis Viruses - genetics</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Liver Diseases - virology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Polymerase Chain Reaction</subject><subject>Schistosomiasis - virology</subject><subject>Seroepidemiologic Studies</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><subject>Virology</subject><subject>Volunteers</subject><issn>0146-6615</issn><issn>1096-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV9v0zAUxSMEYt3gKyA_ILQ9pPhPYscdTJrCKB0bnbQypL1cuY6zGdK4xGlHvz0OqQoSSPjFV1fn_nR0ThS9JXhIMKavD68n-eSIYMljiQU5pDg8esTxiL4hQoxGp5N38fnlDaEnbIiH-fSYxrePosHu4nE0wCThMeck3Yv2vf8aAJmk9Gm0R3AqOSbZIFrnla2tVhXy9q62ZRhrbZAr0WyG1rZZeWTr0ujWujpMaKlaa-rWowfb3iN937hwjSq7Ng0qrDfKG6TqAq1dtapbE7bzyrkCFa52TcdCZ3ebZfsselKqypvn2_8g-vz-bJZ_iC-m40l-ehFrlnAaK2GY4kkqKcdGm0SkzKRZgqUyWaaV4lLxYs5LY9JESzHPEiplmTCtSalZydlB9KrnLhv3fWV8CwvrtakqVRu38iCwkCFZxnYGdOO8b0wJy8YuVLMBgqErBKArBLp4oYsX-kKAY6AQCgEIhcCvQoABhnwa9reB-2JrYDVfmOIPat9AELzcCpQPNZRNyN_63zqapiLp_N30sgdbmc1f5v7j7V_W-kUAxz3Y-tb82IFV8w24YCKFL5_GcD0WHy-vrs5hxn4C1EfDvw</recordid><startdate>200002</startdate><enddate>200002</enddate><creator>Gad, Amal</creator><creator>Tanaka, Eiji</creator><creator>Orii, Kohji</creator><creator>Kafumi, Todoriki</creator><creator>Serwah, Abed El-Hamid</creator><creator>El-Sherif, Asem</creator><creator>Nooman, Zohair</creator><creator>Kiyosawa, Kendo</creator><general>John Wiley & Sons, Inc</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200002</creationdate><title>Clinical significance of TT virus infection in patients with chronic liver disease and volunteer blood donors in Egypt</title><author>Gad, Amal ; Tanaka, Eiji ; Orii, Kohji ; Kafumi, Todoriki ; Serwah, Abed El-Hamid ; El-Sherif, Asem ; Nooman, Zohair ; Kiyosawa, Kendo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3462-a7e3a6459260ece4753e58409ae88caa69a6db6fee54c97b84299f43cc1fc3f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Blood Donors</topic><topic>Chronic Disease</topic><topic>chronic hepatitis</topic><topic>DNA, Viral - blood</topic><topic>Egypt - epidemiology</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hepatitis - epidemiology</topic><topic>Hepatitis - virology</topic><topic>hepatitis B virus</topic><topic>Hepatitis B, Chronic - virology</topic><topic>hepatitis C virus</topic><topic>Hepatitis C, Chronic - virology</topic><topic>Hepatitis Viruses - genetics</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Liver Diseases - virology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Polymerase Chain Reaction</topic><topic>Schistosomiasis - virology</topic><topic>Seroepidemiologic Studies</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><topic>Virology</topic><topic>Volunteers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gad, Amal</creatorcontrib><creatorcontrib>Tanaka, Eiji</creatorcontrib><creatorcontrib>Orii, Kohji</creatorcontrib><creatorcontrib>Kafumi, Todoriki</creatorcontrib><creatorcontrib>Serwah, Abed El-Hamid</creatorcontrib><creatorcontrib>El-Sherif, Asem</creatorcontrib><creatorcontrib>Nooman, Zohair</creatorcontrib><creatorcontrib>Kiyosawa, Kendo</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gad, Amal</au><au>Tanaka, Eiji</au><au>Orii, Kohji</au><au>Kafumi, Todoriki</au><au>Serwah, Abed El-Hamid</au><au>El-Sherif, Asem</au><au>Nooman, Zohair</au><au>Kiyosawa, Kendo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical significance of TT virus infection in patients with chronic liver disease and volunteer blood donors in Egypt</atitle><jtitle>Journal of medical virology</jtitle><addtitle>J. Med. Virol</addtitle><date>2000-02</date><risdate>2000</risdate><volume>60</volume><issue>2</issue><spage>177</spage><epage>181</epage><pages>177-181</pages><issn>0146-6615</issn><eissn>1096-9071</eissn><coden>JMVIDB</coden><abstract>Clinical significance of TT virus (TTV) infection was investigated in Egyptian patients with chronic liver disease and volunteer blood donors by a cross sectional analysis. TTV DNA in serum was assessed by a semi‐nested polymerase chain reaction. The prevalence of TTV DNA did not differ among patients with chronic hepatitis B (11/24, 46%), chronic hepatitis C (22/72, 31%), or schistosomal liver disease (14/39, 36%). No difference in prevalence was found between blood donors (32/109, 29%) and each of the patient groups. Clinical background including mean age, sex distribution, history of blood transfusion, and mean level of alanine aminotransferase did not differ between TTV DNA‐positive and ‐negative individuals in any of the study groups. Ultrasonographic evidence of liver cirrhosis was similar between TTV‐positive and ‐negative patients in each of the chronic liver disease groups. TTV infection was not associated with hepatitis B or C virus infection in blood donors. The only significant difference observed was the lower concentration of serum HCV RNA in TTV DNA positive compared with negative patients with chronic hepatitis C (3.0 ± 1.4 vs. 4.0 ± 0.9 log copies/ml, P < .001). In conclusion, TTV infection was not associated with either past history of blood exposure or infection with bloodborne hepatitis viruses in Egypt. No clinical significance of TTV was found in the present study. However, a reciprocal interaction was suggested between TTV and HCV replication. J. Med. Virol. 60:177–181, 2000. © 2000 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>10596018</pmid><doi>10.1002/(SICI)1096-9071(200002)60:2<177::AID-JMV12>3.0.CO;2-Z</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Aged Biological and medical sciences Blood Donors Chronic Disease chronic hepatitis DNA, Viral - blood Egypt - epidemiology Epidemiology Female Fundamental and applied biological sciences. Psychology Hepatitis - epidemiology Hepatitis - virology hepatitis B virus Hepatitis B, Chronic - virology hepatitis C virus Hepatitis C, Chronic - virology Hepatitis Viruses - genetics Human viral diseases Humans Infectious diseases Liver Diseases - virology Male Medical sciences Microbiology Middle Aged Polymerase Chain Reaction Schistosomiasis - virology Seroepidemiologic Studies Viral diseases Viral hepatitis Virology Volunteers |
| title | Clinical significance of TT virus infection in patients with chronic liver disease and volunteer blood donors in Egypt |
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