Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part I: Diffusion coefficient
In imaging of hyperpolarized noble gases, a knowledge of the diffusion coefficient (D) is important both as a contrast mechanism and in the design of pulse sequences. We have made diffusion coefficient maps of both hyperpolarized 3He and 129Xe in guinea pig lungs. Along the length of the trachea, 3H...
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| Veröffentlicht in: | Magnetic resonance in medicine 1999-10, Vol.42 (4), p.721-728 |
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| container_title | Magnetic resonance in medicine |
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| creator | Chen, X. Josette Möller, Harald E. Chawla, Mark S. Cofer, Gary P. Driehuys, Bastiaan Hedlund, Laurence W. Johnson, G. Allan |
| description | In imaging of hyperpolarized noble gases, a knowledge of the diffusion coefficient (D) is important both as a contrast mechanism and in the design of pulse sequences. We have made diffusion coefficient maps of both hyperpolarized 3He and 129Xe in guinea pig lungs. Along the length of the trachea, 3He D values were on average 2.4 cm2/sec, closely reproducing calculated values for free gas (2.05 cm2/sec). The 3He D values measured perpendicular to the length of the trachea were approximately a factor of two less, indicating restriction to diffusion. Further evidence of restricted diffusion was seen in the distal pulmonary airspaces as the average 3He D was 0.16 cm2/sec. An additional cause for the smaller 3He D in the lung was due to the presence of air, which is composed of heavier and larger gases. The 129Xe results show similar trends, with the trachea D averaging 0.068 cm2/sec and the lung D averaging 0.021 cm2/sec. Magn Reson Med 42:721–728, 1999. © 1999 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/(SICI)1522-2594(199910)42:4<721::AID-MRM14>3.0.CO;2-D |
| format | Article |
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Part I: Diffusion coefficient</title><source>MEDLINE</source><source>Wiley Free Content</source><source>Wiley Online Library All Journals</source><creator>Chen, X. Josette ; Möller, Harald E. ; Chawla, Mark S. ; Cofer, Gary P. ; Driehuys, Bastiaan ; Hedlund, Laurence W. ; Johnson, G. Allan</creator><creatorcontrib>Chen, X. Josette ; Möller, Harald E. ; Chawla, Mark S. ; Cofer, Gary P. ; Driehuys, Bastiaan ; Hedlund, Laurence W. ; Johnson, G. Allan</creatorcontrib><description>In imaging of hyperpolarized noble gases, a knowledge of the diffusion coefficient (D) is important both as a contrast mechanism and in the design of pulse sequences. We have made diffusion coefficient maps of both hyperpolarized 3He and 129Xe in guinea pig lungs. Along the length of the trachea, 3He D values were on average 2.4 cm2/sec, closely reproducing calculated values for free gas (2.05 cm2/sec). The 3He D values measured perpendicular to the length of the trachea were approximately a factor of two less, indicating restriction to diffusion. Further evidence of restricted diffusion was seen in the distal pulmonary airspaces as the average 3He D was 0.16 cm2/sec. An additional cause for the smaller 3He D in the lung was due to the presence of air, which is composed of heavier and larger gases. The 129Xe results show similar trends, with the trachea D averaging 0.068 cm2/sec and the lung D averaging 0.021 cm2/sec. Magn Reson Med 42:721–728, 1999. © 1999 Wiley‐Liss, Inc.</description><identifier>ISSN: 0740-3194</identifier><identifier>EISSN: 1522-2594</identifier><identifier>DOI: 10.1002/(SICI)1522-2594(199910)42:4<721::AID-MRM14>3.0.CO;2-D</identifier><identifier>PMID: 10502761</identifier><identifier>CODEN: MRMEEN</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Animals ; Biological and medical sciences ; diffusion coefficient ; Guinea Pigs ; Helium ; hyperpolarized gas ; in vivo lung imaging ; Investigative techniques, diagnostic techniques (general aspects) ; Isotopes ; Lung - anatomy & histology ; Magnetic Resonance Imaging - methods ; Medical sciences ; Pulmonary Diffusing Capacity ; quantitative map ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Respiratory system ; Xenon Isotopes</subject><ispartof>Magnetic resonance in medicine, 1999-10, Vol.42 (4), p.721-728</ispartof><rights>Copyright © 1999 Wiley‐Liss, Inc.</rights><rights>1999 INIST-CNRS</rights><rights>Copyright 1999 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c5744-8ac32b468a8f60523f3b45cdd2595083c2467f524211e4ed4d1742fd1815e2053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291522-2594%28199910%2942%3A4%3C721%3A%3AAID-MRM14%3E3.0.CO%3B2-D$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291522-2594%28199910%2942%3A4%3C721%3A%3AAID-MRM14%3E3.0.CO%3B2-D$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1993738$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10502761$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, X. Josette</creatorcontrib><creatorcontrib>Möller, Harald E.</creatorcontrib><creatorcontrib>Chawla, Mark S.</creatorcontrib><creatorcontrib>Cofer, Gary P.</creatorcontrib><creatorcontrib>Driehuys, Bastiaan</creatorcontrib><creatorcontrib>Hedlund, Laurence W.</creatorcontrib><creatorcontrib>Johnson, G. Allan</creatorcontrib><title>Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part I: Diffusion coefficient</title><title>Magnetic resonance in medicine</title><addtitle>Magn. Reson. Med</addtitle><description>In imaging of hyperpolarized noble gases, a knowledge of the diffusion coefficient (D) is important both as a contrast mechanism and in the design of pulse sequences. We have made diffusion coefficient maps of both hyperpolarized 3He and 129Xe in guinea pig lungs. Along the length of the trachea, 3He D values were on average 2.4 cm2/sec, closely reproducing calculated values for free gas (2.05 cm2/sec). The 3He D values measured perpendicular to the length of the trachea were approximately a factor of two less, indicating restriction to diffusion. Further evidence of restricted diffusion was seen in the distal pulmonary airspaces as the average 3He D was 0.16 cm2/sec. An additional cause for the smaller 3He D in the lung was due to the presence of air, which is composed of heavier and larger gases. The 129Xe results show similar trends, with the trachea D averaging 0.068 cm2/sec and the lung D averaging 0.021 cm2/sec. Magn Reson Med 42:721–728, 1999. © 1999 Wiley‐Liss, Inc.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>diffusion coefficient</subject><subject>Guinea Pigs</subject><subject>Helium</subject><subject>hyperpolarized gas</subject><subject>in vivo lung imaging</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Isotopes</subject><subject>Lung - anatomy & histology</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Medical sciences</subject><subject>Pulmonary Diffusing Capacity</subject><subject>quantitative map</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Respiratory system</subject><subject>Xenon Isotopes</subject><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV1v0zAYhSMEYt3gLyBfILRdpPgzTsqHNKWsRFopYsAuX7mJvRnSpLOTQvn1uKQqSCBxZev18aPznhNFrwgeE4zp89OrIi_OiKA0piLjpyTLMoLPOJ3wl5KSyeS8mMbzD3PCX7MxHueLFzSe3otGhx_3oxGWHMeMZPwoOvb-C8Y4yyR_GB0RLDCVCRlF_mqtOqvqeouc9m290RVaaeV7p1e66TxqDbrdrrVbt7Vy9kd4vlEerV0bZp3VHtkGdbca1X1zs7tv7KYdo_fKdaiYoKk1pve2bVDZamNsaQP0UfTAqNrrx_vzJPp08eZj_ja-XMyK_PwyLoXkPE5VyeiSJ6lKTYIFZYYtuSirKmwncMpKyhNpBOWUEM11xSsiOTUVSYnQFAt2Ej0buMHtXa99ByvrS13XqtFt70FimRFGKTsYKF3rvdMG1s6ulNsCwbBrA2DXBuyyhV22MLQBnAKH0AZAaAN-tQEMMOQLoDAN3Cd7A_1ypas_qEP8QfB0L1C-VLVxqimt_63LMiZZGmSfB9k3W-vtX-b-4-1f1oZBAMcD2PpOfz-AlfsKiWRSwPW7GcwxYxez2TUw9hO7yMEA</recordid><startdate>199910</startdate><enddate>199910</enddate><creator>Chen, X. Josette</creator><creator>Möller, Harald E.</creator><creator>Chawla, Mark S.</creator><creator>Cofer, Gary P.</creator><creator>Driehuys, Bastiaan</creator><creator>Hedlund, Laurence W.</creator><creator>Johnson, G. Allan</creator><general>John Wiley & Sons, Inc</general><general>Williams & Wilkins</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199910</creationdate><title>Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part I: Diffusion coefficient</title><author>Chen, X. Josette ; Möller, Harald E. ; Chawla, Mark S. ; Cofer, Gary P. ; Driehuys, Bastiaan ; Hedlund, Laurence W. ; Johnson, G. Allan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5744-8ac32b468a8f60523f3b45cdd2595083c2467f524211e4ed4d1742fd1815e2053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>diffusion coefficient</topic><topic>Guinea Pigs</topic><topic>Helium</topic><topic>hyperpolarized gas</topic><topic>in vivo lung imaging</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Isotopes</topic><topic>Lung - anatomy & histology</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Medical sciences</topic><topic>Pulmonary Diffusing Capacity</topic><topic>quantitative map</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Respiratory system</topic><topic>Xenon Isotopes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, X. Josette</creatorcontrib><creatorcontrib>Möller, Harald E.</creatorcontrib><creatorcontrib>Chawla, Mark S.</creatorcontrib><creatorcontrib>Cofer, Gary P.</creatorcontrib><creatorcontrib>Driehuys, Bastiaan</creatorcontrib><creatorcontrib>Hedlund, Laurence W.</creatorcontrib><creatorcontrib>Johnson, G. 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Med</addtitle><date>1999-10</date><risdate>1999</risdate><volume>42</volume><issue>4</issue><spage>721</spage><epage>728</epage><pages>721-728</pages><issn>0740-3194</issn><eissn>1522-2594</eissn><coden>MRMEEN</coden><abstract>In imaging of hyperpolarized noble gases, a knowledge of the diffusion coefficient (D) is important both as a contrast mechanism and in the design of pulse sequences. We have made diffusion coefficient maps of both hyperpolarized 3He and 129Xe in guinea pig lungs. Along the length of the trachea, 3He D values were on average 2.4 cm2/sec, closely reproducing calculated values for free gas (2.05 cm2/sec). The 3He D values measured perpendicular to the length of the trachea were approximately a factor of two less, indicating restriction to diffusion. Further evidence of restricted diffusion was seen in the distal pulmonary airspaces as the average 3He D was 0.16 cm2/sec. An additional cause for the smaller 3He D in the lung was due to the presence of air, which is composed of heavier and larger gases. The 129Xe results show similar trends, with the trachea D averaging 0.068 cm2/sec and the lung D averaging 0.021 cm2/sec. Magn Reson Med 42:721–728, 1999. © 1999 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>10502761</pmid><doi>10.1002/(SICI)1522-2594(199910)42:4<721::AID-MRM14>3.0.CO;2-D</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biological and medical sciences diffusion coefficient Guinea Pigs Helium hyperpolarized gas in vivo lung imaging Investigative techniques, diagnostic techniques (general aspects) Isotopes Lung - anatomy & histology Magnetic Resonance Imaging - methods Medical sciences Pulmonary Diffusing Capacity quantitative map Radiodiagnosis. Nmr imagery. Nmr spectrometry Respiratory system Xenon Isotopes |
| title | Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part I: Diffusion coefficient |
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