An emerging role for agmatine

An emerging role for agmatine. Polyamines, required components of proliferation, are autoregulated by the protein antizyme. To date, agmatine is the only molecule other than the polyamines that can induce antizyme, and thus influence cell homeostasis and growth. Agmatine has effectively suppressed p...

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Veröffentlicht in:	Kidney international 1999-10, Vol.56 (4), p.1252-1253
Hauptverfasser:	Satriano, Joseph, Kelly, Carolyn J., Blantz, Roland C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agmatine - metabolism Animals arginine decarboxylase Biological and medical sciences Cell cycle, cell proliferation Cell Division - physiology cell homeostasis Cell Line, Transformed - cytology Cell Line, Transformed - metabolism Cell physiology Fundamental and applied biological sciences. Psychology Kidney - cytology Kidney - metabolism Molecular and cellular biology polyamines
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creator	Satriano, Joseph Kelly, Carolyn J. Blantz, Roland C.
description	An emerging role for agmatine. Polyamines, required components of proliferation, are autoregulated by the protein antizyme. To date, agmatine is the only molecule other than the polyamines that can induce antizyme, and thus influence cell homeostasis and growth. Agmatine has effectively suppressed proliferation in immortalized and transformed cell lines. An increased sensitivity to the anti-proliferative effects of agmatine observed in Ras transformed versus native cells paralleled an increase in agmatine uptake in the transformed cells. We hypothesize that agmatine may target transformed cells via selective transporters.
doi_str_mv	10.1046/j.1523-1755.1999.00697.x
format	Article
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Polyamines, required components of proliferation, are autoregulated by the protein antizyme. To date, agmatine is the only molecule other than the polyamines that can induce antizyme, and thus influence cell homeostasis and growth. Agmatine has effectively suppressed proliferation in immortalized and transformed cell lines. An increased sensitivity to the anti-proliferative effects of agmatine observed in Ras transformed versus native cells paralleled an increase in agmatine uptake in the transformed cells. 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subjects	Agmatine - metabolism Animals arginine decarboxylase Biological and medical sciences Cell cycle, cell proliferation Cell Division - physiology cell homeostasis Cell Line, Transformed - cytology Cell Line, Transformed - metabolism Cell physiology Fundamental and applied biological sciences. Psychology Kidney - cytology Kidney - metabolism Molecular and cellular biology polyamines
title	An emerging role for agmatine
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