BRCA1/BRCA2 Germline Mutations in Locally Recurrent Breast Cancer Patients After Lumpectomy and Radiation Therapy: Implications for Breast-Conserving Management in Patients With BRCA1/BRCA2 Mutations

Breast cancer patients treated conservatively with lumpectomy and radiation therapy (LRT) have an estimated lifetime risk of local relapse (ipsilateral breast tumor recurrence [IBTR]) of 10% to 15%. For breast cancer patients carrying BRCA1 or BRCA2 (BRCA1/2) mutations, the outcome of treatment with...

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Veröffentlicht in:	Journal of clinical oncology 1999-10, Vol.17 (10), p.3017-3024
Hauptverfasser:	TURNER, B. C, HARROLD, E, HAFFTY, B. G, MATLOFF, E, SMITH, T, GUMBS, A. A, BEINFIELD, M, WARD, B, SKOLNICK, M, GLAZER, P. M, THOMAS, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age of Onset Biological and medical sciences BRCA2 Protein Breast Neoplasms - genetics Breast Neoplasms - radiotherapy Breast Neoplasms - surgery Female Genes, BRCA1 - genetics Germ-Line Mutation Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Mastectomy, Segmental Medical sciences Middle Aged Neoplasm Proteins - genetics Neoplasm Recurrence, Local - genetics Patient Care Planning Risk Assessment Transcription Factors - genetics Treatment Outcome Tumors
Online-Zugang:	Volltext
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