Molecular and Biological Changes Associated with HeLa Cell Attenuation of Wild-Type Yellow Fever Virus

Six passages of the mosquito-borne flavivirus yellow fever (YF) wild-type strain Asibi in HeLa cells attenuated the virus for monkeys and newborn mice and resulted in loss of mosquito competence. Attenuation after the passage in HeLa cells was not unique to YF virus strain Asibi as demonstrated by t...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 1999-09, Vol.261 (2), p.309-318
Hauptverfasser:	Dunster, Lee M., Wang, Heiman, Ryman, Kate D., Miller, Barry R., Watowich, Stanley J., Minor, Philip D., Barrett, Alan D.T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals attenuation flavivirus HeLa Cells - virology Humans Mice Species Specificity Viral Envelope Proteins - physiology Virulence Virus Replication Yellow Fever - virology Yellow fever virus Yellow fever virus - pathogenicity Yellow fever virus - physiology
Online-Zugang:	Volltext
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