[2,1-c] [1,4]Benzodiazepine (PBD)-Distamycin Hybrid Inhibits DNA Binding to Transcription Factor Sp1
We designed and synthesized the hybrid 6, prepared combining the minor groove binders distamycin A and pyrrolo [2,1-c][1,4] benzodiazepine (PBD) 4, related to the natural occurring anthramycin (2) and DC-81 (3). In this paper, the effects of the compound 6 on molecular interactions between DNA and t...
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| Veröffentlicht in: | Nucleosides, nucleotides & nucleic acids nucleotides & nucleic acids, 2000-08, Vol.19 (8), p.1219-1229 |
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| container_title | Nucleosides, nucleotides & nucleic acids |
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| creator | Baraldi, P. G. Cacciarit, B. Guiotto, A. Romagnoli, R. Spalluto, G. Leoni, A. Bianchi, N. Feriotto, G. Rutigliano, C. Mischiati, C. Gambari, Roberto |
| description | We designed and synthesized the hybrid 6, prepared combining the minor groove binders distamycin A and pyrrolo [2,1-c][1,4] benzodiazepine (PBD) 4, related to the natural occurring anthramycin (2) and DC-81 (3). In this paper, the effects of the compound 6 on molecular interactions between DNA and transcription factor Sp1 were studied. The results obtained demonstrate that PBD-distamycin hybrid is a powerful inhibitor of Sp1/DNA interactions. |
| doi_str_mv | 10.1080/15257770008033045 |
| format | Article |
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G. ; Cacciarit, B. ; Guiotto, A. ; Romagnoli, R. ; Spalluto, G. ; Leoni, A. ; Bianchi, N. ; Feriotto, G. ; Rutigliano, C. ; Mischiati, C. ; Gambari, Roberto</creator><creatorcontrib>Baraldi, P. G. ; Cacciarit, B. ; Guiotto, A. ; Romagnoli, R. ; Spalluto, G. ; Leoni, A. ; Bianchi, N. ; Feriotto, G. ; Rutigliano, C. ; Mischiati, C. ; Gambari, Roberto</creatorcontrib><description>We designed and synthesized the hybrid 6, prepared combining the minor groove binders distamycin A and pyrrolo [2,1-c][1,4] benzodiazepine (PBD) 4, related to the natural occurring anthramycin (2) and DC-81 (3). In this paper, the effects of the compound 6 on molecular interactions between DNA and transcription factor Sp1 were studied. The results obtained demonstrate that PBD-distamycin hybrid is a powerful inhibitor of Sp1/DNA interactions.</description><identifier>ISSN: 1525-7770</identifier><identifier>EISSN: 1532-2335</identifier><identifier>DOI: 10.1080/15257770008033045</identifier><identifier>PMID: 11097052</identifier><language>eng</language><publisher>United States: Taylor & Francis Group</publisher><subject>Animals ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Benzodiazepinones - chemical synthesis ; Benzodiazepinones - chemistry ; Benzodiazepinones - pharmacology ; Burkitt Lymphoma - pathology ; Cell Division - drug effects ; Distamycins - chemical synthesis ; Distamycins - chemistry ; Distamycins - pharmacology ; DNA, Neoplasm - drug effects ; DNA, Neoplasm - metabolism ; Drug Screening Assays, Antitumor ; Gene Expression Regulation, Neoplastic - drug effects ; Humans ; K562 Cells - drug effects ; Leukemia L1210 - pathology ; Magnetic Resonance Spectroscopy ; Mice ; Sp1 Transcription Factor - antagonists & inhibitors ; Sp1 Transcription Factor - metabolism ; Transcription, Genetic - drug effects ; Tumor Cells, Cultured - drug effects</subject><ispartof>Nucleosides, nucleotides & nucleic acids, 2000-08, Vol.19 (8), p.1219-1229</ispartof><rights>Copyright Taylor & Francis Group, LLC 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-6f5bb0fe33cf886ede0b48d3889c2c01bb7f4e76e52a8ec8e549550ee24c41c93</citedby><cites>FETCH-LOGICAL-c398t-6f5bb0fe33cf886ede0b48d3889c2c01bb7f4e76e52a8ec8e549550ee24c41c93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/15257770008033045$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/15257770008033045$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,59620,60409</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11097052$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baraldi, P. G.</creatorcontrib><creatorcontrib>Cacciarit, B.</creatorcontrib><creatorcontrib>Guiotto, A.</creatorcontrib><creatorcontrib>Romagnoli, R.</creatorcontrib><creatorcontrib>Spalluto, G.</creatorcontrib><creatorcontrib>Leoni, A.</creatorcontrib><creatorcontrib>Bianchi, N.</creatorcontrib><creatorcontrib>Feriotto, G.</creatorcontrib><creatorcontrib>Rutigliano, C.</creatorcontrib><creatorcontrib>Mischiati, C.</creatorcontrib><creatorcontrib>Gambari, Roberto</creatorcontrib><title>[2,1-c] [1,4]Benzodiazepine (PBD)-Distamycin Hybrid Inhibits DNA Binding to Transcription Factor Sp1</title><title>Nucleosides, nucleotides & nucleic acids</title><addtitle>Nucleosides Nucleotides Nucleic Acids</addtitle><description>We designed and synthesized the hybrid 6, prepared combining the minor groove binders distamycin A and pyrrolo [2,1-c][1,4] benzodiazepine (PBD) 4, related to the natural occurring anthramycin (2) and DC-81 (3). In this paper, the effects of the compound 6 on molecular interactions between DNA and transcription factor Sp1 were studied. The results obtained demonstrate that PBD-distamycin hybrid is a powerful inhibitor of Sp1/DNA interactions.</description><subject>Animals</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Benzodiazepinones - chemical synthesis</subject><subject>Benzodiazepinones - chemistry</subject><subject>Benzodiazepinones - pharmacology</subject><subject>Burkitt Lymphoma - pathology</subject><subject>Cell Division - drug effects</subject><subject>Distamycins - chemical synthesis</subject><subject>Distamycins - chemistry</subject><subject>Distamycins - pharmacology</subject><subject>DNA, Neoplasm - drug effects</subject><subject>DNA, Neoplasm - metabolism</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Gene Expression Regulation, Neoplastic - drug effects</subject><subject>Humans</subject><subject>K562 Cells - drug effects</subject><subject>Leukemia L1210 - pathology</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Mice</subject><subject>Sp1 Transcription Factor - antagonists & inhibitors</subject><subject>Sp1 Transcription Factor - metabolism</subject><subject>Transcription, Genetic - drug effects</subject><subject>Tumor Cells, Cultured - drug effects</subject><issn>1525-7770</issn><issn>1532-2335</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1r3DAQhkVoyVf7A3IpOpUW4nYkWSsZeslmkyYQ2kKTUwhGlseNgi25kpZk8-vrZRd6CKWnmYHnfRkeQo4YfGKg4TOTXCqlAKZDCCjlDtlnUvCCCyFfrXcuizWwRw5SegBgGrTaJXuMQaVA8n3S3vJjVtg7esuOy7s5-ufQOvOMo_NIP_yYLz4WC5eyGVbWeXqxaqJr6aW_d43LiS6-ndC5863zv2gO9Doan2x0Y3bB03Njc4j058jekNed6RO-3c5DcnN-dn16UVx9_3p5enJVWFHpXMw62TTQoRC203qGLUJT6lZoXVlugTWN6kpUM5TcaLQaZVlJCYi8tCWzlTgk7ze9Ywy_l5hyPbhkse-Nx7BMtQKlZ1rBBLINaGNIKWJXj9ENJq5qBvVabf1C7ZR5ty1fNgO2fxNblxOgNoDzXYiDeQyxb-tsVn2I3WTGuvSyts5PeUp--W9S_PuzP3pZl1g</recordid><startdate>200008</startdate><enddate>200008</enddate><creator>Baraldi, P. G.</creator><creator>Cacciarit, B.</creator><creator>Guiotto, A.</creator><creator>Romagnoli, R.</creator><creator>Spalluto, G.</creator><creator>Leoni, A.</creator><creator>Bianchi, N.</creator><creator>Feriotto, G.</creator><creator>Rutigliano, C.</creator><creator>Mischiati, C.</creator><creator>Gambari, Roberto</creator><general>Taylor & Francis Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200008</creationdate><title>[2,1-c] [1,4]Benzodiazepine (PBD)-Distamycin Hybrid Inhibits DNA Binding to Transcription Factor Sp1</title><author>Baraldi, P. G. ; Cacciarit, B. ; Guiotto, A. ; Romagnoli, R. ; Spalluto, G. ; Leoni, A. ; Bianchi, N. ; Feriotto, G. ; Rutigliano, C. ; Mischiati, C. ; Gambari, Roberto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-6f5bb0fe33cf886ede0b48d3889c2c01bb7f4e76e52a8ec8e549550ee24c41c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Benzodiazepinones - chemical synthesis</topic><topic>Benzodiazepinones - chemistry</topic><topic>Benzodiazepinones - pharmacology</topic><topic>Burkitt Lymphoma - pathology</topic><topic>Cell Division - drug effects</topic><topic>Distamycins - chemical synthesis</topic><topic>Distamycins - chemistry</topic><topic>Distamycins - pharmacology</topic><topic>DNA, Neoplasm - drug effects</topic><topic>DNA, Neoplasm - metabolism</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Gene Expression Regulation, Neoplastic - drug effects</topic><topic>Humans</topic><topic>K562 Cells - drug effects</topic><topic>Leukemia L1210 - pathology</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Mice</topic><topic>Sp1 Transcription Factor - antagonists & inhibitors</topic><topic>Sp1 Transcription Factor - metabolism</topic><topic>Transcription, Genetic - drug effects</topic><topic>Tumor Cells, Cultured - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baraldi, P. 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G.</au><au>Cacciarit, B.</au><au>Guiotto, A.</au><au>Romagnoli, R.</au><au>Spalluto, G.</au><au>Leoni, A.</au><au>Bianchi, N.</au><au>Feriotto, G.</au><au>Rutigliano, C.</au><au>Mischiati, C.</au><au>Gambari, Roberto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>[2,1-c] [1,4]Benzodiazepine (PBD)-Distamycin Hybrid Inhibits DNA Binding to Transcription Factor Sp1</atitle><jtitle>Nucleosides, nucleotides & nucleic acids</jtitle><addtitle>Nucleosides Nucleotides Nucleic Acids</addtitle><date>2000-08</date><risdate>2000</risdate><volume>19</volume><issue>8</issue><spage>1219</spage><epage>1229</epage><pages>1219-1229</pages><issn>1525-7770</issn><eissn>1532-2335</eissn><abstract>We designed and synthesized the hybrid 6, prepared combining the minor groove binders distamycin A and pyrrolo [2,1-c][1,4] benzodiazepine (PBD) 4, related to the natural occurring anthramycin (2) and DC-81 (3). 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| subjects | Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Benzodiazepinones - chemical synthesis Benzodiazepinones - chemistry Benzodiazepinones - pharmacology Burkitt Lymphoma - pathology Cell Division - drug effects Distamycins - chemical synthesis Distamycins - chemistry Distamycins - pharmacology DNA, Neoplasm - drug effects DNA, Neoplasm - metabolism Drug Screening Assays, Antitumor Gene Expression Regulation, Neoplastic - drug effects Humans K562 Cells - drug effects Leukemia L1210 - pathology Magnetic Resonance Spectroscopy Mice Sp1 Transcription Factor - antagonists & inhibitors Sp1 Transcription Factor - metabolism Transcription, Genetic - drug effects Tumor Cells, Cultured - drug effects |
| title | [2,1-c] [1,4]Benzodiazepine (PBD)-Distamycin Hybrid Inhibits DNA Binding to Transcription Factor Sp1 |
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