Clinical Relevance of Expression of the CIP/KIP Cell-Cycle Inhibitors p21 and p27 in Laryngeal Cancer
To investigate the prognostic relevance of p21 and p27 protein expression in laryngeal squamous cell carcinoma (LSCC). We have analyzed by immunohistochemistry p21 and p27 expression in a series of 132 patients who underwent surgical resection of their LSCC and who had previously been investigated f...
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| Veröffentlicht in: | Journal of clinical oncology 1999-10, Vol.17 (10), p.3150-3159 |
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| creator | PRUNERI, G PIGNATARO, L CARBONI, N BUFFA, R DI FINIZIO, D CESANA, B. M NERI, A |
| description | To investigate the prognostic relevance of p21 and p27 protein expression in laryngeal squamous cell carcinoma (LSCC).
We have analyzed by immunohistochemistry p21 and p27 expression in a series of 132 patients who underwent surgical resection of their LSCC and who had previously been investigated for p53 gene mutations and cyclin D1 expression. The tumors were considered low expressors when they had |
| doi_str_mv | 10.1200/JCO.1999.17.10.3150 |
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We have analyzed by immunohistochemistry p21 and p27 expression in a series of 132 patients who underwent surgical resection of their LSCC and who had previously been investigated for p53 gene mutations and cyclin D1 expression. The tumors were considered low expressors when they had </= 10% of p21 and </= 50% of p27 immunoreactive neoplastic cells.
In 41 cases (31.1%), p21 was expressed in </= 10% of neoplastic cells; in 91 cases (68.9%), it was expressed in more than 10% of neoplastic cells. In 11 cases (8.3%), p27 was expressed in less than 5% of neoplastic cells; in 39 cases (29.6%), it was expressed in 5% to 50% of neoplastic cells; and in 82 cases (62.1%), it was expressed in more than 50% of the neoplastic cells. Low levels of p21 expression were associated with poor histologic differentiation and lymph node metastases. Low levels of p27 expression were associated with tumor extension and advanced clinical stage. Expression of p21 and p27 was not correlated with p53 gene status, and low p27 expression was more frequently detected in the cyclin D1-positive cases, with a borderline level of statistical significance. At univariate analysis, anatomic site, tumor extension, clinical stage, high cyclin D1 expression, and low p27 expression were significantly associated with reduced disease-free and overall survival rates. At multivariate analysis, high cyclin D1 expression and low p27 expression were the only significant covariates. The patients with a cyclin D1(+)/p27(-) phenotype had the poorest disease-free and overall survival rates.
Our study provides evidence that the immunohistochemical evaluation of p27 expression is a significant independent predictor of prognosis in laryngeal carcinoma.</description><identifier>ISSN: 0732-183X</identifier><identifier>EISSN: 1527-7755</identifier><identifier>DOI: 10.1200/JCO.1999.17.10.3150</identifier><identifier>PMID: 10506612</identifier><language>eng</language><publisher>Baltimore, MD: American Society of Clinical Oncology</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Biomarkers, Tumor - analysis ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - pathology ; Cell Cycle ; Cell Cycle Proteins ; Cyclin-Dependent Kinase Inhibitor p21 ; Cyclin-Dependent Kinase Inhibitor p27 ; Cyclins - biosynthesis ; Cyclins - genetics ; Disease-Free Survival ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Immunohistochemistry ; Laryngeal Neoplasms - metabolism ; Laryngeal Neoplasms - pathology ; Male ; Medical sciences ; Microtubule-Associated Proteins - biosynthesis ; Microtubule-Associated Proteins - genetics ; Middle Aged ; Otorhinolaryngology. Stomatology ; Predictive Value of Tests ; Prognosis ; Retrospective Studies ; Tumor Suppressor Proteins ; Tumors ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>Journal of clinical oncology, 1999-10, Vol.17 (10), p.3150-3159</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-656b0486ba667e04d826dbeed141e89cde2d05caf9d92b556ab5969f87700d933</citedby><cites>FETCH-LOGICAL-c362t-656b0486ba667e04d826dbeed141e89cde2d05caf9d92b556ab5969f87700d933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1950222$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10506612$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PRUNERI, G</creatorcontrib><creatorcontrib>PIGNATARO, L</creatorcontrib><creatorcontrib>CARBONI, N</creatorcontrib><creatorcontrib>BUFFA, R</creatorcontrib><creatorcontrib>DI FINIZIO, D</creatorcontrib><creatorcontrib>CESANA, B. M</creatorcontrib><creatorcontrib>NERI, A</creatorcontrib><title>Clinical Relevance of Expression of the CIP/KIP Cell-Cycle Inhibitors p21 and p27 in Laryngeal Cancer</title><title>Journal of clinical oncology</title><addtitle>J Clin Oncol</addtitle><description>To investigate the prognostic relevance of p21 and p27 protein expression in laryngeal squamous cell carcinoma (LSCC).
We have analyzed by immunohistochemistry p21 and p27 expression in a series of 132 patients who underwent surgical resection of their LSCC and who had previously been investigated for p53 gene mutations and cyclin D1 expression. The tumors were considered low expressors when they had </= 10% of p21 and </= 50% of p27 immunoreactive neoplastic cells.
In 41 cases (31.1%), p21 was expressed in </= 10% of neoplastic cells; in 91 cases (68.9%), it was expressed in more than 10% of neoplastic cells. In 11 cases (8.3%), p27 was expressed in less than 5% of neoplastic cells; in 39 cases (29.6%), it was expressed in 5% to 50% of neoplastic cells; and in 82 cases (62.1%), it was expressed in more than 50% of the neoplastic cells. Low levels of p21 expression were associated with poor histologic differentiation and lymph node metastases. Low levels of p27 expression were associated with tumor extension and advanced clinical stage. Expression of p21 and p27 was not correlated with p53 gene status, and low p27 expression was more frequently detected in the cyclin D1-positive cases, with a borderline level of statistical significance. At univariate analysis, anatomic site, tumor extension, clinical stage, high cyclin D1 expression, and low p27 expression were significantly associated with reduced disease-free and overall survival rates. At multivariate analysis, high cyclin D1 expression and low p27 expression were the only significant covariates. The patients with a cyclin D1(+)/p27(-) phenotype had the poorest disease-free and overall survival rates.
Our study provides evidence that the immunohistochemical evaluation of p27 expression is a significant independent predictor of prognosis in laryngeal carcinoma.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Cell Cycle</subject><subject>Cell Cycle Proteins</subject><subject>Cyclin-Dependent Kinase Inhibitor p21</subject><subject>Cyclin-Dependent Kinase Inhibitor p27</subject><subject>Cyclins - biosynthesis</subject><subject>Cyclins - genetics</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Laryngeal Neoplasms - metabolism</subject><subject>Laryngeal Neoplasms - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microtubule-Associated Proteins - biosynthesis</subject><subject>Microtubule-Associated Proteins - genetics</subject><subject>Middle Aged</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Tumor Suppressor Proteins</subject><subject>Tumors</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>0732-183X</issn><issn>1527-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkMFqGzEQhkVJady0TxAIOoT0tM5Ia0mrY1iS1q0hobTQm9BKs7GCvOtIdtu8fbXY0JwGDd_8mvkIOWcwZxzg-mt7P2da6zlT89KrmYA3ZMYEV5VSQpyQGaiaV6ypf52S9zk_AbBFU4t35JSBACkZnxFsYxiCs5F-x4i_7eCQjj29_btNmHMYh-m1WyNtlw_X35YPtMUYq_bFRaTLYR26sBtTplvOqB18qYqGga5sehkesaS2U2L6QN72Nmb8eKxn5Ofd7Y_2S7W6_7xsb1aVqyXfVVLIDhaN7KyUCmHhGy59h-jZgmGjnUfuQTjba695J4S0ndBS941SAF7X9Rm5OuRu0_i8x7wzm5Bd2dgOOO6zUaAaqRpWwPoAujTmnLA32xQ2ZWvDwEx2TbFrJruGqak32S1TF8f4fbdB_2rmoLMAl0fA5uK0T-X6kP9zWgDnE_bpgK3D4_pPSGjyxsZYUrl5cuOrH_8B6IGNlg</recordid><startdate>19991001</startdate><enddate>19991001</enddate><creator>PRUNERI, G</creator><creator>PIGNATARO, L</creator><creator>CARBONI, N</creator><creator>BUFFA, R</creator><creator>DI FINIZIO, D</creator><creator>CESANA, B. M</creator><creator>NERI, A</creator><general>American Society of Clinical Oncology</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19991001</creationdate><title>Clinical Relevance of Expression of the CIP/KIP Cell-Cycle Inhibitors p21 and p27 in Laryngeal Cancer</title><author>PRUNERI, G ; PIGNATARO, L ; CARBONI, N ; BUFFA, R ; DI FINIZIO, D ; CESANA, B. M ; NERI, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-656b0486ba667e04d826dbeed141e89cde2d05caf9d92b556ab5969f87700d933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Cell Cycle</topic><topic>Cell Cycle Proteins</topic><topic>Cyclin-Dependent Kinase Inhibitor p21</topic><topic>Cyclin-Dependent Kinase Inhibitor p27</topic><topic>Cyclins - biosynthesis</topic><topic>Cyclins - genetics</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Laryngeal Neoplasms - metabolism</topic><topic>Laryngeal Neoplasms - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microtubule-Associated Proteins - biosynthesis</topic><topic>Microtubule-Associated Proteins - genetics</topic><topic>Middle Aged</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Tumor Suppressor Proteins</topic><topic>Tumors</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PRUNERI, G</creatorcontrib><creatorcontrib>PIGNATARO, L</creatorcontrib><creatorcontrib>CARBONI, N</creatorcontrib><creatorcontrib>BUFFA, R</creatorcontrib><creatorcontrib>DI FINIZIO, D</creatorcontrib><creatorcontrib>CESANA, B. M</creatorcontrib><creatorcontrib>NERI, A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PRUNERI, G</au><au>PIGNATARO, L</au><au>CARBONI, N</au><au>BUFFA, R</au><au>DI FINIZIO, D</au><au>CESANA, B. M</au><au>NERI, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Relevance of Expression of the CIP/KIP Cell-Cycle Inhibitors p21 and p27 in Laryngeal Cancer</atitle><jtitle>Journal of clinical oncology</jtitle><addtitle>J Clin Oncol</addtitle><date>1999-10-01</date><risdate>1999</risdate><volume>17</volume><issue>10</issue><spage>3150</spage><epage>3159</epage><pages>3150-3159</pages><issn>0732-183X</issn><eissn>1527-7755</eissn><abstract>To investigate the prognostic relevance of p21 and p27 protein expression in laryngeal squamous cell carcinoma (LSCC).
We have analyzed by immunohistochemistry p21 and p27 expression in a series of 132 patients who underwent surgical resection of their LSCC and who had previously been investigated for p53 gene mutations and cyclin D1 expression. The tumors were considered low expressors when they had </= 10% of p21 and </= 50% of p27 immunoreactive neoplastic cells.
In 41 cases (31.1%), p21 was expressed in </= 10% of neoplastic cells; in 91 cases (68.9%), it was expressed in more than 10% of neoplastic cells. In 11 cases (8.3%), p27 was expressed in less than 5% of neoplastic cells; in 39 cases (29.6%), it was expressed in 5% to 50% of neoplastic cells; and in 82 cases (62.1%), it was expressed in more than 50% of the neoplastic cells. Low levels of p21 expression were associated with poor histologic differentiation and lymph node metastases. Low levels of p27 expression were associated with tumor extension and advanced clinical stage. Expression of p21 and p27 was not correlated with p53 gene status, and low p27 expression was more frequently detected in the cyclin D1-positive cases, with a borderline level of statistical significance. At univariate analysis, anatomic site, tumor extension, clinical stage, high cyclin D1 expression, and low p27 expression were significantly associated with reduced disease-free and overall survival rates. At multivariate analysis, high cyclin D1 expression and low p27 expression were the only significant covariates. The patients with a cyclin D1(+)/p27(-) phenotype had the poorest disease-free and overall survival rates.
Our study provides evidence that the immunohistochemical evaluation of p27 expression is a significant independent predictor of prognosis in laryngeal carcinoma.</abstract><cop>Baltimore, MD</cop><pub>American Society of Clinical Oncology</pub><pmid>10506612</pmid><doi>10.1200/JCO.1999.17.10.3150</doi><tpages>10</tpages></addata></record> |
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| subjects | Adult Aged Biological and medical sciences Biomarkers, Tumor - analysis Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell Cycle Cell Cycle Proteins Cyclin-Dependent Kinase Inhibitor p21 Cyclin-Dependent Kinase Inhibitor p27 Cyclins - biosynthesis Cyclins - genetics Disease-Free Survival Female Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Laryngeal Neoplasms - metabolism Laryngeal Neoplasms - pathology Male Medical sciences Microtubule-Associated Proteins - biosynthesis Microtubule-Associated Proteins - genetics Middle Aged Otorhinolaryngology. Stomatology Predictive Value of Tests Prognosis Retrospective Studies Tumor Suppressor Proteins Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Clinical Relevance of Expression of the CIP/KIP Cell-Cycle Inhibitors p21 and p27 in Laryngeal Cancer |
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