Antibodies against vascular endothelial growth factor improve early renal dysfunction in experimental diabetes

Vascular endothelial growth factor (VEGF) is a cytokine that potently stimulates angiogenesis, microvascular hyperpermeability, and endothelium-dependent vasodilation, effects that are largely mediated by endothelial nitric oxide synthase (eNOS). The expression of VEGF is pronounced in glomerular vi...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2001-05, Vol.12 (5), p.993-1000
Hauptverfasser:	DE VRIESE, An S, TILTON, Ronald G, ELGER, Marlies, STEPHAN, Clifford C, KRIZ, Wilhelm, LAMEIRE, Norbert H
Format:	Artikel
Sprache:	eng
Schlagworte:	Albuminuria - therapy Animals Antibodies, Monoclonal - administration & dosage Biological and medical sciences Diabetes Mellitus, Experimental - physiopathology Diabetes Mellitus, Experimental - therapy Diabetic Nephropathies - physiopathology Diabetic Nephropathies - therapy Endothelial Growth Factors - antagonists & inhibitors Endothelial Growth Factors - immunology Endothelial Growth Factors - physiology Female Kidney Glomerulus - physiopathology Lymphokines - antagonists & inhibitors Lymphokines - immunology Lymphokines - physiology Medical sciences Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type III Pharmacology. Drug treatments Rats Rats, Wistar Urinary system Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors
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