Depolarization Affects the Binding Properties of Muscarinic Acetylcholine Receptors and Their Interaction with Proteins of the Exocytic Apparatus

Membrane depolarization is the signal that triggers release of neurotransmitter from nerve terminals. As a result of depolarization, voltage-dependent Ca2+channels open, level of intracellular Ca2+ increases. and release of neurotransmitter commences. Previous study had shown that in rat brain synap...

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Veröffentlicht in:	The Journal of biological chemistry 1999-10, Vol.274 (41), p.29519-29528
Hauptverfasser:	Ilouz, Nili, Branski, Leora, Parnis, Julia, Parnas, Hanna, Linial, Michal
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - metabolism Animals Binding, Competitive Brain - metabolism Calcium - metabolism Carbachol - metabolism CHO Cells Cricetinae Exocytosis Humans Membrane Potentials Membrane Proteins - metabolism Muscarinic Agonists - pharmacology Muscarinic Antagonists - pharmacology N-Methylscopolamine - metabolism Protein Binding Qa-SNARE Proteins Rats Receptors, Muscarinic - classification Receptors, Muscarinic - metabolism Synaptosomes - metabolism Transfection
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