Extracellular signal-regulated kinase functions in the urokinase receptor-dependent pathway by which neutralization of low density lipoprotein receptor-related protein promotes fibrosarcoma cell migration and matrigel invasion

The low density lipoprotein receptor-related protein (LRP) has been reported to regulate cellular migration. In this study, an antisense RNA expression strategy was used to reduce LRP to undetectable levels in HT 1080 fibrosarcoma cells. The LRP-deficient cells demonstrated increased levels of cell-...

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Veröffentlicht in:	Journal of cell science 2000-01, Vol.113 ( Pt 1) (1), p.123-134
Hauptverfasser:	Webb, D J, Nguyen, D H, Gonias, S L
Format:	Artikel
Sprache:	eng
Schlagworte:	Aprotinin - pharmacology Autocrine Communication Cell Movement - drug effects Collagen - metabolism Culture Media, Conditioned Drug Combinations Enzyme Activation - drug effects Fibrosarcoma - enzymology Fibrosarcoma - metabolism Fibrosarcoma - pathology Flavonoids - pharmacology Humans Laminin - metabolism Low Density Lipoprotein Receptor-Related Protein-1 MAP Kinase Kinase 1 Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinase Kinases - genetics Mitogen-Activated Protein Kinase Kinases - metabolism Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - metabolism Mutation - genetics Neoplasm Invasiveness Phosphorylation Protein Serine-Threonine Kinases Proteoglycans - metabolism Receptors, Cell Surface - antagonists & inhibitors Receptors, Cell Surface - metabolism Receptors, Immunologic - deficiency Receptors, Immunologic - genetics Receptors, Immunologic - physiology Receptors, LDL - genetics Receptors, LDL - physiology Receptors, Urokinase Plasminogen Activator RNA, Antisense - genetics RNA, Antisense - physiology Signal Transduction Transfection Tumor Cells, Cultured Urokinase-Type Plasminogen Activator - antagonists & inhibitors Urokinase-Type Plasminogen Activator - metabolism Vitronectin - metabolism
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