Enhanced solubility and dissolution rate of itraconazole by a solid dispersion technique

The aim of the present study was to improve the solubility and dissolution rate of a poorly water-soluble drug, itraconazole, by a solid dispersion technique. Solid dispersion particles of itraconazole were prepared with various pH-independent and -dependent hydrophilic polymers and were characteriz...

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Veröffentlicht in:	International journal of pharmaceutics 1999-10, Vol.187 (2), p.209-218
Hauptverfasser:	Jung, Jae-Young, Yoo, Sun Dong, Lee, Sang-Heon, Kim, Kye-Hyun, Yoon, Doo-Sun, Lee, Kyu-Hyun
Format:	Artikel
Sprache:	eng
Schlagworte:	AEA Antifungal Agents - chemistry Biological and medical sciences Calorimetry, Differential Scanning Dissolution Eudragit® E 100 General pharmacology Itraconazole Itraconazole - analysis Itraconazole - chemistry Medical sciences Microscopy, Electron, Scanning Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Solid dispersion Solubility Spray drying X-Ray Diffraction
Online-Zugang:	Volltext
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