Selective Gene Delivery to Head and Neck Cancer Cells via an Integrin Targeted Adenoviral Vector

In vivo cancer gene therapy approaches for squamous cell carcinoma of the head and neck (SCCHN) based on adenoviral vector-mediated gene delivery have been limited by the suboptimal efficacy of gene transfer to tumor cells. We hypothesized that this issue was due to deficiency of the primary adenovi...

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Veröffentlicht in:	Clinical cancer research 1999-09, Vol.5 (9), p.2571-2579
Hauptverfasser:	KASONO, K, BLACKWELL, J. L, CURIEL, D. T, KRASNYKH, V, DOUGLAS, J. T, DMITRIEV, I, STRONG, T. V, REYNOLDS, P, KROPF, D. A, CARROLL, W. R, PETERS, G. E, BUCY, R. P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Biological and medical sciences Biomarkers, Tumor Biotechnology Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - therapy Coxsackie and Adenovirus Receptor-Like Membrane Protein Fundamental and applied biological sciences. Psychology Gene therapy Genetic Therapy - methods Genetic Vectors Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - therapy Health. Pharmaceutical industry HeLa Cells Humans Industrial applications and implications. Economical aspects Integrin alpha3beta1 Integrins - biosynthesis Integrins - metabolism Medical sciences Oligopeptides - genetics Oligopeptides - metabolism Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Receptors, Collagen Receptors, Virus - biosynthesis Tumor Cells, Cultured Tumors
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