Dynamic MR imaging (DEMRI) of microcirculation in bone sarcoma
If chemotherapy is to be effective against bone sarcoma, the cytotoxic agents must reach all tumor cells in effective quantities. Although many clinical trials include studies of the pharmacokinetics of these agents in blood or cerebrospinal fluid, there have been no accurate or widely applicable me...
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Veröffentlicht in: | Journal of magnetic resonance imaging 1999-09, Vol.10 (3), p.277-285 |
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description | If chemotherapy is to be effective against bone sarcoma, the cytotoxic agents must reach all tumor cells in effective quantities. Although many clinical trials include studies of the pharmacokinetics of these agents in blood or cerebrospinal fluid, there have been no accurate or widely applicable methods of determining whether chemotherapeutic agents reach all regions of a solid tumor. This review discusses the use of dynamic contrast‐enhanced magnetic resonance imaging (DEMRI) to assess the microcirculation and interstitium of bone sarcoma. DEMRI studies provide a means of exploring leakage of contrast agent into tumor interstitium (extracellular extravascular spaces [EES]). In clinical observations of numerous series of patients with bone sarcoma, measures of contrast uptake (access) have convincingly demonstrated a relationship with measures and predictions of the tumor's response to preoperative chemotherapy. The results of these studies have indicated that greater access at the time of presentation, greater decrease in access during therapy, and low access at the completion of preoperative therapy correspond to better response and longer disease‐free survival. Although questions remain about how these novel dynamic imaging methods can best be used to measure drug access noninvasively, we are optimistic that such measures can be developed to reflect the range of biological variation within and between naturally occurring solid tumors. J. Magn. Reson. Imaging 1999;10:277–285. © 1999 Wiley‐Liss, Inc. |
doi_str_mv | 10.1002/(SICI)1522-2586(199909)10:3<277::AID-JMRI8>3.0.CO;2-S |
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Although many clinical trials include studies of the pharmacokinetics of these agents in blood or cerebrospinal fluid, there have been no accurate or widely applicable methods of determining whether chemotherapeutic agents reach all regions of a solid tumor. This review discusses the use of dynamic contrast‐enhanced magnetic resonance imaging (DEMRI) to assess the microcirculation and interstitium of bone sarcoma. DEMRI studies provide a means of exploring leakage of contrast agent into tumor interstitium (extracellular extravascular spaces [EES]). In clinical observations of numerous series of patients with bone sarcoma, measures of contrast uptake (access) have convincingly demonstrated a relationship with measures and predictions of the tumor's response to preoperative chemotherapy. The results of these studies have indicated that greater access at the time of presentation, greater decrease in access during therapy, and low access at the completion of preoperative therapy correspond to better response and longer disease‐free survival. Although questions remain about how these novel dynamic imaging methods can best be used to measure drug access noninvasively, we are optimistic that such measures can be developed to reflect the range of biological variation within and between naturally occurring solid tumors. J. Magn. Reson. Imaging 1999;10:277–285. © 1999 Wiley‐Liss, Inc.</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/(SICI)1522-2586(199909)10:3<277::AID-JMRI8>3.0.CO;2-S</identifier><identifier>PMID: 10508287</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Antineoplastic Agents - therapeutic use ; bone neoplasms ; Bone Neoplasms - blood supply ; Bone Neoplasms - drug therapy ; Bone Neoplasms - pathology ; Child ; Contrast Media - pharmacokinetics ; Disease-Free Survival ; dynamic contrast MR ; Extracellular Space - metabolism ; Gadolinium DTPA - pharmacokinetics ; Humans ; Magnetic Resonance Imaging - methods ; Microcirculation - pathology ; Neovascularization, Pathologic - pathology ; Osteosarcoma - blood supply ; Osteosarcoma - drug therapy ; Osteosarcoma - pathology ; Predictive Value of Tests ; Preoperative Care ; Proportional Hazards Models ; Regression Analysis ; Retrospective Studies ; Sarcoma, Ewing - blood supply ; Sarcoma, Ewing - drug therapy ; Sarcoma, Ewing - pathology ; therapy efficacy ; tumor microcirculation ; tumor response</subject><ispartof>Journal of magnetic resonance imaging, 1999-09, Vol.10 (3), p.277-285</ispartof><rights>Copyright © 1999 Wiley‐Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4798-57246d7a92d45312d9168e665f4a2f7a1cdfc5ef2b17f308f16a1f5abaf0383e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291522-2586%28199909%2910%3A3%3C277%3A%3AAID-JMRI8%3E3.0.CO%3B2-S$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291522-2586%28199909%2910%3A3%3C277%3A%3AAID-JMRI8%3E3.0.CO%3B2-S$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10508287$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Reddick, Wilburn E.</creatorcontrib><creatorcontrib>Taylor, June S.</creatorcontrib><creatorcontrib>Fletcher, Barry D.</creatorcontrib><title>Dynamic MR imaging (DEMRI) of microcirculation in bone sarcoma</title><title>Journal of magnetic resonance imaging</title><addtitle>J. Magn. Reson. Imaging</addtitle><description>If chemotherapy is to be effective against bone sarcoma, the cytotoxic agents must reach all tumor cells in effective quantities. Although many clinical trials include studies of the pharmacokinetics of these agents in blood or cerebrospinal fluid, there have been no accurate or widely applicable methods of determining whether chemotherapeutic agents reach all regions of a solid tumor. This review discusses the use of dynamic contrast‐enhanced magnetic resonance imaging (DEMRI) to assess the microcirculation and interstitium of bone sarcoma. DEMRI studies provide a means of exploring leakage of contrast agent into tumor interstitium (extracellular extravascular spaces [EES]). In clinical observations of numerous series of patients with bone sarcoma, measures of contrast uptake (access) have convincingly demonstrated a relationship with measures and predictions of the tumor's response to preoperative chemotherapy. The results of these studies have indicated that greater access at the time of presentation, greater decrease in access during therapy, and low access at the completion of preoperative therapy correspond to better response and longer disease‐free survival. Although questions remain about how these novel dynamic imaging methods can best be used to measure drug access noninvasively, we are optimistic that such measures can be developed to reflect the range of biological variation within and between naturally occurring solid tumors. J. Magn. Reson. Imaging 1999;10:277–285. © 1999 Wiley‐Liss, Inc.</description><subject>Antineoplastic Agents - therapeutic use</subject><subject>bone neoplasms</subject><subject>Bone Neoplasms - blood supply</subject><subject>Bone Neoplasms - drug therapy</subject><subject>Bone Neoplasms - pathology</subject><subject>Child</subject><subject>Contrast Media - pharmacokinetics</subject><subject>Disease-Free Survival</subject><subject>dynamic contrast MR</subject><subject>Extracellular Space - metabolism</subject><subject>Gadolinium DTPA - pharmacokinetics</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Microcirculation - pathology</subject><subject>Neovascularization, Pathologic - pathology</subject><subject>Osteosarcoma - blood supply</subject><subject>Osteosarcoma - drug therapy</subject><subject>Osteosarcoma - pathology</subject><subject>Predictive Value of Tests</subject><subject>Preoperative Care</subject><subject>Proportional Hazards Models</subject><subject>Regression Analysis</subject><subject>Retrospective Studies</subject><subject>Sarcoma, Ewing - blood supply</subject><subject>Sarcoma, Ewing - drug therapy</subject><subject>Sarcoma, Ewing - pathology</subject><subject>therapy efficacy</subject><subject>tumor microcirculation</subject><subject>tumor response</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1v0zAUhiMEYmPwF1CuUHuRcmzHsV1g0pRuI2ijUsvH7o7cxJ488jHiVtB_j0OmCgkkrmyd9_g5x08UvSMwIwD09WRd5MWUcEoTymU2IUopUFMCc_aWCjGfnxWL5MP1qpCnbAazfPmGJutH0fHhxeNwB84SIkEcRc-8vwMApVL-NDoKAUgqxXF0uti3unFlfL2KXaNvXXsbTxbngTuNOxuHpO9K15e7Wm9d18aujTdda2Kv-7Jr9PPoidW1Ny8ezpPo88X5p_x9crW8LPKzq6RMhZIJFzTNKqEVrVLOCK0UyaTJMm5TTa3QpKxsyY2lGyIsA2lJponleqMtMMkMO4lejdz7vvu-M36LjfOlqWvdmm7nUYCQNBPADguEvb3vjcX7Pvyr3yMBHMQiDmJx0ISDJhzFDjHDIBYxiMXfYkMBMF8ixXXgvnxYYLdpTPUHdTQZGr6MDT9cbfZ_Tf3P0H_NHAsBnIxg57fm5wGs-2-YCSY4fv14iav8RsGFWuAN-wX_EaEY</recordid><startdate>199909</startdate><enddate>199909</enddate><creator>Reddick, Wilburn E.</creator><creator>Taylor, June S.</creator><creator>Fletcher, Barry D.</creator><general>John Wiley & Sons, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199909</creationdate><title>Dynamic MR imaging (DEMRI) of microcirculation in bone sarcoma</title><author>Reddick, Wilburn E. ; Taylor, June S. ; Fletcher, Barry D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4798-57246d7a92d45312d9168e665f4a2f7a1cdfc5ef2b17f308f16a1f5abaf0383e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Antineoplastic Agents - therapeutic use</topic><topic>bone neoplasms</topic><topic>Bone Neoplasms - blood supply</topic><topic>Bone Neoplasms - drug therapy</topic><topic>Bone Neoplasms - pathology</topic><topic>Child</topic><topic>Contrast Media - pharmacokinetics</topic><topic>Disease-Free Survival</topic><topic>dynamic contrast MR</topic><topic>Extracellular Space - metabolism</topic><topic>Gadolinium DTPA - pharmacokinetics</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Microcirculation - pathology</topic><topic>Neovascularization, Pathologic - pathology</topic><topic>Osteosarcoma - blood supply</topic><topic>Osteosarcoma - drug therapy</topic><topic>Osteosarcoma - pathology</topic><topic>Predictive Value of Tests</topic><topic>Preoperative Care</topic><topic>Proportional Hazards Models</topic><topic>Regression Analysis</topic><topic>Retrospective Studies</topic><topic>Sarcoma, Ewing - blood supply</topic><topic>Sarcoma, Ewing - drug therapy</topic><topic>Sarcoma, Ewing - pathology</topic><topic>therapy efficacy</topic><topic>tumor microcirculation</topic><topic>tumor response</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reddick, Wilburn E.</creatorcontrib><creatorcontrib>Taylor, June S.</creatorcontrib><creatorcontrib>Fletcher, Barry D.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reddick, Wilburn E.</au><au>Taylor, June S.</au><au>Fletcher, Barry D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dynamic MR imaging (DEMRI) of microcirculation in bone sarcoma</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J. Magn. Reson. Imaging</addtitle><date>1999-09</date><risdate>1999</risdate><volume>10</volume><issue>3</issue><spage>277</spage><epage>285</epage><pages>277-285</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>If chemotherapy is to be effective against bone sarcoma, the cytotoxic agents must reach all tumor cells in effective quantities. Although many clinical trials include studies of the pharmacokinetics of these agents in blood or cerebrospinal fluid, there have been no accurate or widely applicable methods of determining whether chemotherapeutic agents reach all regions of a solid tumor. This review discusses the use of dynamic contrast‐enhanced magnetic resonance imaging (DEMRI) to assess the microcirculation and interstitium of bone sarcoma. DEMRI studies provide a means of exploring leakage of contrast agent into tumor interstitium (extracellular extravascular spaces [EES]). In clinical observations of numerous series of patients with bone sarcoma, measures of contrast uptake (access) have convincingly demonstrated a relationship with measures and predictions of the tumor's response to preoperative chemotherapy. The results of these studies have indicated that greater access at the time of presentation, greater decrease in access during therapy, and low access at the completion of preoperative therapy correspond to better response and longer disease‐free survival. Although questions remain about how these novel dynamic imaging methods can best be used to measure drug access noninvasively, we are optimistic that such measures can be developed to reflect the range of biological variation within and between naturally occurring solid tumors. J. Magn. Reson. 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subjects | Antineoplastic Agents - therapeutic use bone neoplasms Bone Neoplasms - blood supply Bone Neoplasms - drug therapy Bone Neoplasms - pathology Child Contrast Media - pharmacokinetics Disease-Free Survival dynamic contrast MR Extracellular Space - metabolism Gadolinium DTPA - pharmacokinetics Humans Magnetic Resonance Imaging - methods Microcirculation - pathology Neovascularization, Pathologic - pathology Osteosarcoma - blood supply Osteosarcoma - drug therapy Osteosarcoma - pathology Predictive Value of Tests Preoperative Care Proportional Hazards Models Regression Analysis Retrospective Studies Sarcoma, Ewing - blood supply Sarcoma, Ewing - drug therapy Sarcoma, Ewing - pathology therapy efficacy tumor microcirculation tumor response |
title | Dynamic MR imaging (DEMRI) of microcirculation in bone sarcoma |
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