Functional characterization of soluble and membrane-bound forms of vaccinia virus complement control protein (VCP)

Vaccinia virus secretes a 35 kD protein, vaccinia virus complement control protein (VCP), that inhibits the classical and alternative pathways of complement at several points, indicating that it may be a viral analogue of human complement receptor type 1 (CR1; CD35). Structurally, however, CR1 is co...

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Veröffentlicht in:	Molecular immunology 1999-07, Vol.36 (10), p.685-697
Hauptverfasser:	Rosengard, Ariella M, Alonso, Laura C, Korb, Laura C, Baldwin, William M, Sanfilippo, Fred, Turka, Laurence A, Ahearn, Joseph M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Membrane Complement Complement C3b - immunology complement control protein Complement Inactivator Proteins complement receptors Complement System Proteins - immunology Consensus Sequence Convertase Humans L Cells (Cell Line) Mice Receptors, Complement 3b - immunology Receptors, Complement 3d - immunology Regulators of complement activation Short consensus repeats Solubility Vaccinia complement control protein vaccinia virus Vaccinia virus - chemistry Vaccinia virus - immunology Vaccinia virus - physiology Viral Proteins - chemistry Viral Proteins - immunology Viral Proteins - physiology
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