Gene discovery and vesicoureteric reflux
Vesicoureteric reflux (VUR) is a congenital urinary tract defect caused by abnormal insertion of the ureter within the bladder wall. This leads to a defective ureterovesical junction in which urine flows retrogradely from the bladder to the kidneys. Although VUR is associated with recurrent urinary...
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| Veröffentlicht in: | Pediatric nephrology (Berlin, West) West), 2008-07, Vol.23 (7), p.1021-1027 |
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| creator | Murawski, Inga J. Gupta, Indra R. |
| description | Vesicoureteric reflux (VUR) is a congenital urinary tract defect caused by abnormal insertion of the ureter within the bladder wall. This leads to a defective ureterovesical junction in which urine flows retrogradely from the bladder to the kidneys. Although VUR is associated with recurrent urinary tract infections, renal malformations, hypertension, and reflux nephropathy, its relationship to each of these clinical entities is poorly understood. Mutations in genes expressed by the developing kidney and urinary tract can cause VUR in mice, and some of these same genes have been identified in humans with VUR. By discovering the genes that are associated with VUR, new hypotheses will be generated such that, eventually, the relationship between VUR and its complications will be understood. |
| doi_str_mv | 10.1007/s00467-007-0704-y |
| format | Article |
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This leads to a defective ureterovesical junction in which urine flows retrogradely from the bladder to the kidneys. Although VUR is associated with recurrent urinary tract infections, renal malformations, hypertension, and reflux nephropathy, its relationship to each of these clinical entities is poorly understood. Mutations in genes expressed by the developing kidney and urinary tract can cause VUR in mice, and some of these same genes have been identified in humans with VUR. 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| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Bladder Congenital diseases Disease Models, Animal Gene Expression Regulation, Developmental Genes Genetic Predisposition to Disease Humans Kidney diseases Medicine & Public Health Mice Mice, Transgenic Mutation Nephrology Pediatrics Phenotype Review Risk Factors Ureter - abnormalities Urinary tract diseases Urinary tract infections Urine Urogenital system Urology Vesico-Ureteral Reflux - complications Vesico-Ureteral Reflux - genetics Vesico-Ureteral Reflux - pathology |
| title | Gene discovery and vesicoureteric reflux |
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