Type I Collagen Induces Expression of Bone Morphogenetic Protein Receptor Type II
The extracellular matrix regulates many fundamental cellular processes such as proliferation, migration, and differentiation. Among the ECM components, type I collagen induces endothelial tube formation in vitro. By analysing genes participating in this event, the bone morphogenetic protein receptor...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2001-05, Vol.283 (2), p.316-322 |
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| creator | Regazzoni, Carlo Winterhalter, Kaspar H. Rohrer, Lucia |
| description | The extracellular matrix regulates many fundamental cellular processes such as proliferation, migration, and differentiation. Among the ECM components, type I collagen induces endothelial tube formation in vitro. By analysing genes participating in this event, the bone morphogenetic protein receptor-II (BMPR-II) was detected to be upregulated in cells cultured on or within fibrillar type I collagen. Furthermore, the basement membrane type IV collagen or amorphous type I collagen did not show an induction of BMPR-II. Addition of the BMPR-II specific ligands, BMP2 and BMP4, in the culture medium of the endothelial cells seeded on type I collagen increased [3H]-thymidine incorporation into cellular DNA, indicating that endothelial cells were able to form a functional receptor. In addition, in the chick chorioallantoic membrane (CAM), an in vivo angiogenesis model, BMPR-II and BMPR-I were upregulated in the growing phase and ceased in the mature CAM. |
| doi_str_mv | 10.1006/bbrc.2001.4813 |
| format | Article |
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Among the ECM components, type I collagen induces endothelial tube formation in vitro. By analysing genes participating in this event, the bone morphogenetic protein receptor-II (BMPR-II) was detected to be upregulated in cells cultured on or within fibrillar type I collagen. Furthermore, the basement membrane type IV collagen or amorphous type I collagen did not show an induction of BMPR-II. Addition of the BMPR-II specific ligands, BMP2 and BMP4, in the culture medium of the endothelial cells seeded on type I collagen increased [3H]-thymidine incorporation into cellular DNA, indicating that endothelial cells were able to form a functional receptor. 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Among the ECM components, type I collagen induces endothelial tube formation in vitro. By analysing genes participating in this event, the bone morphogenetic protein receptor-II (BMPR-II) was detected to be upregulated in cells cultured on or within fibrillar type I collagen. Furthermore, the basement membrane type IV collagen or amorphous type I collagen did not show an induction of BMPR-II. Addition of the BMPR-II specific ligands, BMP2 and BMP4, in the culture medium of the endothelial cells seeded on type I collagen increased [3H]-thymidine incorporation into cellular DNA, indicating that endothelial cells were able to form a functional receptor. In addition, in the chick chorioallantoic membrane (CAM), an in vivo angiogenesis model, BMPR-II and BMPR-I were upregulated in the growing phase and ceased in the mature CAM.</description><subject>Allantois - metabolism</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>BMPR</subject><subject>bone morphogenetic protein receptor</subject><subject>bone morphogenetic protein receptors</subject><subject>Bone Morphogenetic Protein Receptors, Type II</subject><subject>Bone Morphogenetic Proteins - metabolism</subject><subject>Cattle</subject><subject>Cell Division - drug effects</subject><subject>Cells, Cultured</subject><subject>Chick Embryo</subject><subject>Chorion - metabolism</subject><subject>Collagen - classification</subject><subject>Collagen - metabolism</subject><subject>Collagen - pharmacology</subject><subject>differential display</subject><subject>DNA Primers - genetics</subject><subject>endothelial cells</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Endothelium, Vascular - metabolism</subject><subject>Gene Expression - drug effects</subject><subject>Gene Expression Profiling</subject><subject>Neovascularization, Physiologic</subject><subject>Protein-Serine-Threonine Kinases - genetics</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>tube formation</subject><subject>type I collagen</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0DtP8zAUh3ELgaBcVkbkiS3lnNiN4xEqLpVAXAQSmxU7J-9r1MbBThF8e1K1EhNi8vLzXzoPY8cIYwQozqyNbpwD4FiWKLbYCEFDliPIbTaCQWS5xtc9tp_S26BQFnqX7SGKXCmAEXt8_uqIz_g0zOfVP2r5rK2XjhK__OwipeRDy0PDL0JL_C7E7n8YEPXe8YcYevItfyJHXR8iXy_NDtlOU80THW3eA_Zydfk8vclu769n0_PbzAmFfUZO2VxqKyY52EmuSzHRk0Zg5TQ4KWxRqbKw0uqqRumsBaCmKpGwziXVQooDdrre7WJ4X1LqzcInR8MZLYVlMgpUCbJUf0JUpRaoiwGO19DFkFKkxnTRL6r4ZRDMqrZZ1Tar2mZVe_hwslle2gXVP3yTdwDlGtAQ4sNTNMl5ah3VPpLrTR38b9vfAUuNRQ</recordid><startdate>20010504</startdate><enddate>20010504</enddate><creator>Regazzoni, Carlo</creator><creator>Winterhalter, Kaspar H.</creator><creator>Rohrer, Lucia</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>20010504</creationdate><title>Type I Collagen Induces Expression of Bone Morphogenetic Protein Receptor Type II</title><author>Regazzoni, Carlo ; Winterhalter, Kaspar H. ; Rohrer, Lucia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-ec7b249b3520b52983595f31ac90c43b6a786b4b9ad14cbb00efa81e1d24ed343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Allantois - metabolism</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>BMPR</topic><topic>bone morphogenetic protein receptor</topic><topic>bone morphogenetic protein receptors</topic><topic>Bone Morphogenetic Protein Receptors, Type II</topic><topic>Bone Morphogenetic Proteins - metabolism</topic><topic>Cattle</topic><topic>Cell Division - drug effects</topic><topic>Cells, Cultured</topic><topic>Chick Embryo</topic><topic>Chorion - metabolism</topic><topic>Collagen - classification</topic><topic>Collagen - metabolism</topic><topic>Collagen - pharmacology</topic><topic>differential display</topic><topic>DNA Primers - genetics</topic><topic>endothelial cells</topic><topic>Endothelium, Vascular - drug effects</topic><topic>Endothelium, Vascular - metabolism</topic><topic>Gene Expression - drug effects</topic><topic>Gene Expression Profiling</topic><topic>Neovascularization, Physiologic</topic><topic>Protein-Serine-Threonine Kinases - genetics</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>tube formation</topic><topic>type I collagen</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Regazzoni, Carlo</creatorcontrib><creatorcontrib>Winterhalter, Kaspar H.</creatorcontrib><creatorcontrib>Rohrer, Lucia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Regazzoni, Carlo</au><au>Winterhalter, Kaspar H.</au><au>Rohrer, Lucia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Type I Collagen Induces Expression of Bone Morphogenetic Protein Receptor Type II</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2001-05-04</date><risdate>2001</risdate><volume>283</volume><issue>2</issue><spage>316</spage><epage>322</epage><pages>316-322</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>The extracellular matrix regulates many fundamental cellular processes such as proliferation, migration, and differentiation. Among the ECM components, type I collagen induces endothelial tube formation in vitro. By analysing genes participating in this event, the bone morphogenetic protein receptor-II (BMPR-II) was detected to be upregulated in cells cultured on or within fibrillar type I collagen. Furthermore, the basement membrane type IV collagen or amorphous type I collagen did not show an induction of BMPR-II. Addition of the BMPR-II specific ligands, BMP2 and BMP4, in the culture medium of the endothelial cells seeded on type I collagen increased [3H]-thymidine incorporation into cellular DNA, indicating that endothelial cells were able to form a functional receptor. In addition, in the chick chorioallantoic membrane (CAM), an in vivo angiogenesis model, BMPR-II and BMPR-I were upregulated in the growing phase and ceased in the mature CAM.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>11327700</pmid><doi>10.1006/bbrc.2001.4813</doi><tpages>7</tpages></addata></record> |
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| subjects | Allantois - metabolism Animals Base Sequence BMPR bone morphogenetic protein receptor bone morphogenetic protein receptors Bone Morphogenetic Protein Receptors, Type II Bone Morphogenetic Proteins - metabolism Cattle Cell Division - drug effects Cells, Cultured Chick Embryo Chorion - metabolism Collagen - classification Collagen - metabolism Collagen - pharmacology differential display DNA Primers - genetics endothelial cells Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Gene Expression - drug effects Gene Expression Profiling Neovascularization, Physiologic Protein-Serine-Threonine Kinases - genetics Reverse Transcriptase Polymerase Chain Reaction tube formation type I collagen |
| title | Type I Collagen Induces Expression of Bone Morphogenetic Protein Receptor Type II |
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