Plasma apolipoprotein B-48, hepatic apolipoprotein B mRNA editing and apolipoprotein B mRNA editing catalytic subunit-1 mRNA levels are altered in zinc-deficient rats

Apolipoprotein B (apoB) exists as two major isoforms and serves as an obligatory component of lipid-rich plasma lipoprotein particles. Apolipoprotein B mRNA editing is a zinc-dependent, site-specific cytidine deamination that determines whether the apoB-100 or apoB-48 isoform is synthesized. The obj...

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Veröffentlicht in:	The Journal of nutrition 1999-10, Vol.129 (10), p.1855-1861
Hauptverfasser:	REAVES, S. K, FANZO, J. C, WU, J. Y. J, YI RAN WANG, WU, Y. W, LEI ZHU, LEI, K. Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apolipoproteins B - blood Apolipoproteins B - genetics Apolipoproteins B - metabolism Biological and medical sciences Body Weight Diet Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Liver - metabolism Male Organ Size Rats Rats, Sprague-Dawley RNA Editing RNA, Messenger - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems Zinc - blood Zinc - deficiency
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Zusammenfassung:	Apolipoprotein B (apoB) exists as two major isoforms and serves as an obligatory component of lipid-rich plasma lipoprotein particles. Apolipoprotein B mRNA editing is a zinc-dependent, site-specific cytidine deamination that determines whether the apoB-100 or apoB-48 isoform is synthesized. The objective of this work was to examine whether dietary zinc levels affect apoB mRNA editing in vivo. Adult male Sprague-Dawley rats were randomly assigned to zinc-deficient (ZD,
ISSN:	0022-3166 1541-6100
DOI:	10.1093/jn/129.10.1855