Neutrophil infiltration into human gliomas
Human gliomas were analysed for the infiltration of neutrophils using immunohistochemistry by staining sections for CD15-positive and myeloperoxidase-positive cells. Over 70% of all glioma samples analysed (n = 105) had significant neutrophil infiltration, but there was a marked and significant corr...
Gespeichert in:
| Veröffentlicht in: | Acta neuropathologica 1999-10, Vol.98 (4), p.349-354 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 354 |
|---|---|
| container_issue | 4 |
| container_start_page | 349 |
| container_title | Acta neuropathologica |
| container_volume | 98 |
| creator | FOSSATI, G RICEVUTI, G EDWARDS, S. W WALKER, C DALTON, A ROSSI, M. L |
| description | Human gliomas were analysed for the infiltration of neutrophils using immunohistochemistry by staining sections for CD15-positive and myeloperoxidase-positive cells. Over 70% of all glioma samples analysed (n = 105) had significant neutrophil infiltration, but there was a marked and significant correlation between tumour grade and the extent of the neutrophil infiltration. In the low grade tumours only 40-50% had significant infiltration, while in glioblastoma multiforme over 85% of the samples analysed had significant infiltration. Numbers of neutrophils infiltrating glioblastoma multiforme tumours were also greater than in the other tumour groups. Circulating white blood cell counts were elevated above the normal range in all glioma patients, but this elevation was entirely due to increased numbers of circulating neutrophils. Again, the highest numbers of circulating neutrophils were seen in the glioblastoma multiforme patients. These experiments indicate that glioma-derived factors may directly or indirectly affect the number of circulating neutrophils and influence their infiltration into the tumours. |
| doi_str_mv | 10.1007/s004010051093 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70779293</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70779293</sourcerecordid><originalsourceid>FETCH-LOGICAL-c346t-a849039cda8f08161ae3cebadebaf8405c4d24a02cbc29c2514901bb3f7788453</originalsourceid><addsrcrecordid>eNpd0EtLAzEUBeAgitbq0q0UFBfC6M1rMllK8QVFN7oOmUxiU2YmNZlZ-O9NacHHItxc-DhcDkJnGG4wgLhNAAzyj2OQdA9NMKOkAE7pPpoAAC5KSsgROk5plTciGD9ERxg4EKBygq5f7DjEsF76duZ759sh6sGHPi9DmC3HTvezj9aHTqcTdOB0m-zpbk7R-8P92_ypWLw-Ps_vFoWhrBwKXTGZo02jKwcVLrG21NhaN_m5igE3rCFMAzG1IdIQjrPHdU2dEFXFOJ2iq23uOobP0aZBdT4Z27a6t2FMSoAQkkia4cU_uApj7PNtijDMucjJG1VslYkhpWidWkff6filMKhNhepPhdmf71LHurPNL73tLIPLHdDJ6NZF3RuffpxkZSko_QZNhnZI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2415571493</pqid></control><display><type>article</type><title>Neutrophil infiltration into human gliomas</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>FOSSATI, G ; RICEVUTI, G ; EDWARDS, S. W ; WALKER, C ; DALTON, A ; ROSSI, M. L</creator><creatorcontrib>FOSSATI, G ; RICEVUTI, G ; EDWARDS, S. W ; WALKER, C ; DALTON, A ; ROSSI, M. L</creatorcontrib><description>Human gliomas were analysed for the infiltration of neutrophils using immunohistochemistry by staining sections for CD15-positive and myeloperoxidase-positive cells. Over 70% of all glioma samples analysed (n = 105) had significant neutrophil infiltration, but there was a marked and significant correlation between tumour grade and the extent of the neutrophil infiltration. In the low grade tumours only 40-50% had significant infiltration, while in glioblastoma multiforme over 85% of the samples analysed had significant infiltration. Numbers of neutrophils infiltrating glioblastoma multiforme tumours were also greater than in the other tumour groups. Circulating white blood cell counts were elevated above the normal range in all glioma patients, but this elevation was entirely due to increased numbers of circulating neutrophils. Again, the highest numbers of circulating neutrophils were seen in the glioblastoma multiforme patients. These experiments indicate that glioma-derived factors may directly or indirectly affect the number of circulating neutrophils and influence their infiltration into the tumours.</description><identifier>ISSN: 0001-6322</identifier><identifier>EISSN: 1432-0533</identifier><identifier>DOI: 10.1007/s004010051093</identifier><identifier>PMID: 10502039</identifier><identifier>CODEN: ANPTAL</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Biological and medical sciences ; Bone Marrow - pathology ; Brain Neoplasms - blood supply ; Brain Neoplasms - pathology ; Cell Death - physiology ; Glioblastoma ; Glioblastoma - blood supply ; Glioblastoma - pathology ; Glioma ; Glioma - blood supply ; Glioma - pathology ; Humans ; Immunohistochemistry ; Infiltration ; Leukocyte Count ; Leukocytes (neutrophilic) ; Medical sciences ; Metastases ; Necrosis ; Neovascularization, Pathologic - pathology ; Neurology ; Neutrophil Infiltration - physiology ; Neutrophils ; Neutrophils - physiology ; Peroxidase ; Tumors ; Tumors of the nervous system. Phacomatoses</subject><ispartof>Acta neuropathologica, 1999-10, Vol.98 (4), p.349-354</ispartof><rights>1999 INIST-CNRS</rights><rights>Springer-Verlag Berlin Heidelberg 1999.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c346t-a849039cda8f08161ae3cebadebaf8405c4d24a02cbc29c2514901bb3f7788453</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1946673$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10502039$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FOSSATI, G</creatorcontrib><creatorcontrib>RICEVUTI, G</creatorcontrib><creatorcontrib>EDWARDS, S. W</creatorcontrib><creatorcontrib>WALKER, C</creatorcontrib><creatorcontrib>DALTON, A</creatorcontrib><creatorcontrib>ROSSI, M. L</creatorcontrib><title>Neutrophil infiltration into human gliomas</title><title>Acta neuropathologica</title><addtitle>Acta Neuropathol</addtitle><description>Human gliomas were analysed for the infiltration of neutrophils using immunohistochemistry by staining sections for CD15-positive and myeloperoxidase-positive cells. Over 70% of all glioma samples analysed (n = 105) had significant neutrophil infiltration, but there was a marked and significant correlation between tumour grade and the extent of the neutrophil infiltration. In the low grade tumours only 40-50% had significant infiltration, while in glioblastoma multiforme over 85% of the samples analysed had significant infiltration. Numbers of neutrophils infiltrating glioblastoma multiforme tumours were also greater than in the other tumour groups. Circulating white blood cell counts were elevated above the normal range in all glioma patients, but this elevation was entirely due to increased numbers of circulating neutrophils. Again, the highest numbers of circulating neutrophils were seen in the glioblastoma multiforme patients. These experiments indicate that glioma-derived factors may directly or indirectly affect the number of circulating neutrophils and influence their infiltration into the tumours.</description><subject>Biological and medical sciences</subject><subject>Bone Marrow - pathology</subject><subject>Brain Neoplasms - blood supply</subject><subject>Brain Neoplasms - pathology</subject><subject>Cell Death - physiology</subject><subject>Glioblastoma</subject><subject>Glioblastoma - blood supply</subject><subject>Glioblastoma - pathology</subject><subject>Glioma</subject><subject>Glioma - blood supply</subject><subject>Glioma - pathology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Infiltration</subject><subject>Leukocyte Count</subject><subject>Leukocytes (neutrophilic)</subject><subject>Medical sciences</subject><subject>Metastases</subject><subject>Necrosis</subject><subject>Neovascularization, Pathologic - pathology</subject><subject>Neurology</subject><subject>Neutrophil Infiltration - physiology</subject><subject>Neutrophils</subject><subject>Neutrophils - physiology</subject><subject>Peroxidase</subject><subject>Tumors</subject><subject>Tumors of the nervous system. Phacomatoses</subject><issn>0001-6322</issn><issn>1432-0533</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpd0EtLAzEUBeAgitbq0q0UFBfC6M1rMllK8QVFN7oOmUxiU2YmNZlZ-O9NacHHItxc-DhcDkJnGG4wgLhNAAzyj2OQdA9NMKOkAE7pPpoAAC5KSsgROk5plTciGD9ERxg4EKBygq5f7DjEsF76duZ759sh6sGHPi9DmC3HTvezj9aHTqcTdOB0m-zpbk7R-8P92_ypWLw-Ps_vFoWhrBwKXTGZo02jKwcVLrG21NhaN_m5igE3rCFMAzG1IdIQjrPHdU2dEFXFOJ2iq23uOobP0aZBdT4Z27a6t2FMSoAQkkia4cU_uApj7PNtijDMucjJG1VslYkhpWidWkff6filMKhNhepPhdmf71LHurPNL73tLIPLHdDJ6NZF3RuffpxkZSko_QZNhnZI</recordid><startdate>19991001</startdate><enddate>19991001</enddate><creator>FOSSATI, G</creator><creator>RICEVUTI, G</creator><creator>EDWARDS, S. W</creator><creator>WALKER, C</creator><creator>DALTON, A</creator><creator>ROSSI, M. L</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>19991001</creationdate><title>Neutrophil infiltration into human gliomas</title><author>FOSSATI, G ; RICEVUTI, G ; EDWARDS, S. W ; WALKER, C ; DALTON, A ; ROSSI, M. L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c346t-a849039cda8f08161ae3cebadebaf8405c4d24a02cbc29c2514901bb3f7788453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Biological and medical sciences</topic><topic>Bone Marrow - pathology</topic><topic>Brain Neoplasms - blood supply</topic><topic>Brain Neoplasms - pathology</topic><topic>Cell Death - physiology</topic><topic>Glioblastoma</topic><topic>Glioblastoma - blood supply</topic><topic>Glioblastoma - pathology</topic><topic>Glioma</topic><topic>Glioma - blood supply</topic><topic>Glioma - pathology</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Infiltration</topic><topic>Leukocyte Count</topic><topic>Leukocytes (neutrophilic)</topic><topic>Medical sciences</topic><topic>Metastases</topic><topic>Necrosis</topic><topic>Neovascularization, Pathologic - pathology</topic><topic>Neurology</topic><topic>Neutrophil Infiltration - physiology</topic><topic>Neutrophils</topic><topic>Neutrophils - physiology</topic><topic>Peroxidase</topic><topic>Tumors</topic><topic>Tumors of the nervous system. Phacomatoses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FOSSATI, G</creatorcontrib><creatorcontrib>RICEVUTI, G</creatorcontrib><creatorcontrib>EDWARDS, S. W</creatorcontrib><creatorcontrib>WALKER, C</creatorcontrib><creatorcontrib>DALTON, A</creatorcontrib><creatorcontrib>ROSSI, M. L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Acta neuropathologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FOSSATI, G</au><au>RICEVUTI, G</au><au>EDWARDS, S. W</au><au>WALKER, C</au><au>DALTON, A</au><au>ROSSI, M. L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neutrophil infiltration into human gliomas</atitle><jtitle>Acta neuropathologica</jtitle><addtitle>Acta Neuropathol</addtitle><date>1999-10-01</date><risdate>1999</risdate><volume>98</volume><issue>4</issue><spage>349</spage><epage>354</epage><pages>349-354</pages><issn>0001-6322</issn><eissn>1432-0533</eissn><coden>ANPTAL</coden><abstract>Human gliomas were analysed for the infiltration of neutrophils using immunohistochemistry by staining sections for CD15-positive and myeloperoxidase-positive cells. Over 70% of all glioma samples analysed (n = 105) had significant neutrophil infiltration, but there was a marked and significant correlation between tumour grade and the extent of the neutrophil infiltration. In the low grade tumours only 40-50% had significant infiltration, while in glioblastoma multiforme over 85% of the samples analysed had significant infiltration. Numbers of neutrophils infiltrating glioblastoma multiforme tumours were also greater than in the other tumour groups. Circulating white blood cell counts were elevated above the normal range in all glioma patients, but this elevation was entirely due to increased numbers of circulating neutrophils. Again, the highest numbers of circulating neutrophils were seen in the glioblastoma multiforme patients. These experiments indicate that glioma-derived factors may directly or indirectly affect the number of circulating neutrophils and influence their infiltration into the tumours.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>10502039</pmid><doi>10.1007/s004010051093</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0001-6322 |
| ispartof | Acta neuropathologica, 1999-10, Vol.98 (4), p.349-354 |
| issn | 0001-6322 1432-0533 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70779293 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Biological and medical sciences Bone Marrow - pathology Brain Neoplasms - blood supply Brain Neoplasms - pathology Cell Death - physiology Glioblastoma Glioblastoma - blood supply Glioblastoma - pathology Glioma Glioma - blood supply Glioma - pathology Humans Immunohistochemistry Infiltration Leukocyte Count Leukocytes (neutrophilic) Medical sciences Metastases Necrosis Neovascularization, Pathologic - pathology Neurology Neutrophil Infiltration - physiology Neutrophils Neutrophils - physiology Peroxidase Tumors Tumors of the nervous system. Phacomatoses |
| title | Neutrophil infiltration into human gliomas |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T22%3A16%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Neutrophil%20infiltration%20into%20human%20gliomas&rft.jtitle=Acta%20neuropathologica&rft.au=FOSSATI,%20G&rft.date=1999-10-01&rft.volume=98&rft.issue=4&rft.spage=349&rft.epage=354&rft.pages=349-354&rft.issn=0001-6322&rft.eissn=1432-0533&rft.coden=ANPTAL&rft_id=info:doi/10.1007/s004010051093&rft_dat=%3Cproquest_cross%3E70779293%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2415571493&rft_id=info:pmid/10502039&rfr_iscdi=true |