S-Acyl-2-thioethyl Aryl Phosphotriester Derivatives as Mononucleotide Prodrugs

The synthesis and biological activities of phosphotriester derivatives of 3‘-azido-2‘,3‘-dideoxythymidine (AZT) bearing a phenyl group or l-tyrosinyl residues are reported. The target compounds were obtained via either PV or PIII chemistry from the appropriate aryl precursors. All the derivatives we...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 2000-11, Vol.43 (23), p.4570-4574
Hauptverfasser:	Schlienger, Nathalie, Peyrottes, Suzanne, Kassem, Tarek, Imbach, Jean-Louis, Gosselin, Gilles, Aubertin, Anne-Marie, Périgaud, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-HIV Agents - chemical synthesis Anti-HIV Agents - chemistry Anti-HIV Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Cell Line HIV-1 - drug effects Hydrolysis Medical sciences Organophosphates - chemical synthesis Organophosphates - chemistry Organophosphates - pharmacology Pharmacology. Drug treatments Prodrugs - chemical synthesis Prodrugs - chemistry Prodrugs - pharmacology Structure-Activity Relationship Thymidine Kinase - deficiency Virus Replication Zidovudine - analogs & derivatives Zidovudine - chemical synthesis Zidovudine - chemistry Zidovudine - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!