Juvenile idiopathic arthritis in multicase families
To characterize juvenile idiopathic arthritis (JIA) patients from multicase families. The study series comprised 80 affected siblings belonging to 37 families. Comparisons were made with a population-based series of JIA patients from Finland and with a sibling series from the United States. The dist...
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| Veröffentlicht in: | Clinical and experimental rheumatology 2001-03, Vol.19 (2), p.218-220 |
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| container_title | Clinical and experimental rheumatology |
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| creator | SÄILÄ, H. M SAVOLAINEN, H. A KOTANIEMI, K. M KAIPIAINEN-SEPPÄNEN, O. A LEIRISALO-REPO, M. T AHO, K. V |
| description | To characterize juvenile idiopathic arthritis (JIA) patients from multicase families.
The study series comprised 80 affected siblings belonging to 37 families. Comparisons were made with a population-based series of JIA patients from Finland and with a sibling series from the United States.
The distribution of cases according to onset type was similar in the sibling and population-based series. The age at diagnosis was significantly lower in the sibling series (4.8 years vs 7.4 years; p < 0.001). There was more intra-pair similarity in onset and course types in the United States series compared to the Finnish series and the proportion of girls was higher in the former.
The only significant difference between familial and sporadic cases with JIA is an earlier onset of disease in familial cases. There is no essential difference in clinical features of the disease between patients in the multicase and sporadic groups. Differences between the Finnish and US series may be due to selection bias in the latter. |
| format | Article |
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The study series comprised 80 affected siblings belonging to 37 families. Comparisons were made with a population-based series of JIA patients from Finland and with a sibling series from the United States.
The distribution of cases according to onset type was similar in the sibling and population-based series. The age at diagnosis was significantly lower in the sibling series (4.8 years vs 7.4 years; p < 0.001). There was more intra-pair similarity in onset and course types in the United States series compared to the Finnish series and the proportion of girls was higher in the former.
The only significant difference between familial and sporadic cases with JIA is an earlier onset of disease in familial cases. There is no essential difference in clinical features of the disease between patients in the multicase and sporadic groups. Differences between the Finnish and US series may be due to selection bias in the latter.</description><identifier>ISSN: 0392-856X</identifier><identifier>EISSN: 1593-098X</identifier><identifier>PMID: 11326489</identifier><language>eng</language><publisher>Pisa: Clinical and Experimental Rheumatology</publisher><subject>Age of Onset ; Arthritis, Juvenile - epidemiology ; Arthritis, Juvenile - genetics ; Biological and medical sciences ; Child ; Diseases of the osteoarticular system ; Family Health ; Female ; Finland - epidemiology ; Genetic Predisposition to Disease ; Humans ; Inflammatory joint diseases ; Male ; Medical sciences ; Prevalence ; United States - epidemiology</subject><ispartof>Clinical and experimental rheumatology, 2001-03, Vol.19 (2), p.218-220</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=989787$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11326489$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SÄILÄ, H. M</creatorcontrib><creatorcontrib>SAVOLAINEN, H. A</creatorcontrib><creatorcontrib>KOTANIEMI, K. M</creatorcontrib><creatorcontrib>KAIPIAINEN-SEPPÄNEN, O. A</creatorcontrib><creatorcontrib>LEIRISALO-REPO, M. T</creatorcontrib><creatorcontrib>AHO, K. V</creatorcontrib><title>Juvenile idiopathic arthritis in multicase families</title><title>Clinical and experimental rheumatology</title><addtitle>Clin Exp Rheumatol</addtitle><description>To characterize juvenile idiopathic arthritis (JIA) patients from multicase families.
The study series comprised 80 affected siblings belonging to 37 families. Comparisons were made with a population-based series of JIA patients from Finland and with a sibling series from the United States.
The distribution of cases according to onset type was similar in the sibling and population-based series. The age at diagnosis was significantly lower in the sibling series (4.8 years vs 7.4 years; p < 0.001). There was more intra-pair similarity in onset and course types in the United States series compared to the Finnish series and the proportion of girls was higher in the former.
The only significant difference between familial and sporadic cases with JIA is an earlier onset of disease in familial cases. There is no essential difference in clinical features of the disease between patients in the multicase and sporadic groups. Differences between the Finnish and US series may be due to selection bias in the latter.</description><subject>Age of Onset</subject><subject>Arthritis, Juvenile - epidemiology</subject><subject>Arthritis, Juvenile - genetics</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Diseases of the osteoarticular system</subject><subject>Family Health</subject><subject>Female</subject><subject>Finland - epidemiology</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Inflammatory joint diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Prevalence</subject><subject>United States - epidemiology</subject><issn>0392-856X</issn><issn>1593-098X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9z0tLw0AYheFBFFurf0ECgrvAXDK3pRS1SsGNQndhbrGfTC7OJIL_3oDR1dk8HHhP0JpwzUqs1eEUrTHTtFRcHFboIucPjKngQp6jFSGMikrpNWLP01foIIYCPPSDGY_gCpPGY4IRcgFd0U5xBGdyKBrTQoSQL9FZY2IOV8tu0NvD_et2V-5fHp-2d_vynQoylt4ri5XzVlAjMJcuOMEqrLm1UktCSKCEiUArzYzn2ntnpaVN5aXnYsZsg25_f4fUf04hj3UL2YUYTRf6KdcSSyk0ozO8XuBk2-DrIUFr0nf9lzmDmwWY7Exskukc5H-nlZZKsh905VxT</recordid><startdate>20010301</startdate><enddate>20010301</enddate><creator>SÄILÄ, H. M</creator><creator>SAVOLAINEN, H. A</creator><creator>KOTANIEMI, K. M</creator><creator>KAIPIAINEN-SEPPÄNEN, O. A</creator><creator>LEIRISALO-REPO, M. T</creator><creator>AHO, K. V</creator><general>Clinical and Experimental Rheumatology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20010301</creationdate><title>Juvenile idiopathic arthritis in multicase families</title><author>SÄILÄ, H. M ; SAVOLAINEN, H. A ; KOTANIEMI, K. M ; KAIPIAINEN-SEPPÄNEN, O. A ; LEIRISALO-REPO, M. T ; AHO, K. V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g261t-dd8b08cdb62a6057cec634095bb797111e2136e2493ad59ddcb7b2f4d7d56cec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Age of Onset</topic><topic>Arthritis, Juvenile - epidemiology</topic><topic>Arthritis, Juvenile - genetics</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Diseases of the osteoarticular system</topic><topic>Family Health</topic><topic>Female</topic><topic>Finland - epidemiology</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Inflammatory joint diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Prevalence</topic><topic>United States - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SÄILÄ, H. M</creatorcontrib><creatorcontrib>SAVOLAINEN, H. A</creatorcontrib><creatorcontrib>KOTANIEMI, K. M</creatorcontrib><creatorcontrib>KAIPIAINEN-SEPPÄNEN, O. A</creatorcontrib><creatorcontrib>LEIRISALO-REPO, M. T</creatorcontrib><creatorcontrib>AHO, K. V</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SÄILÄ, H. M</au><au>SAVOLAINEN, H. A</au><au>KOTANIEMI, K. M</au><au>KAIPIAINEN-SEPPÄNEN, O. A</au><au>LEIRISALO-REPO, M. T</au><au>AHO, K. V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Juvenile idiopathic arthritis in multicase families</atitle><jtitle>Clinical and experimental rheumatology</jtitle><addtitle>Clin Exp Rheumatol</addtitle><date>2001-03-01</date><risdate>2001</risdate><volume>19</volume><issue>2</issue><spage>218</spage><epage>220</epage><pages>218-220</pages><issn>0392-856X</issn><eissn>1593-098X</eissn><abstract>To characterize juvenile idiopathic arthritis (JIA) patients from multicase families.
The study series comprised 80 affected siblings belonging to 37 families. Comparisons were made with a population-based series of JIA patients from Finland and with a sibling series from the United States.
The distribution of cases according to onset type was similar in the sibling and population-based series. The age at diagnosis was significantly lower in the sibling series (4.8 years vs 7.4 years; p < 0.001). There was more intra-pair similarity in onset and course types in the United States series compared to the Finnish series and the proportion of girls was higher in the former.
The only significant difference between familial and sporadic cases with JIA is an earlier onset of disease in familial cases. There is no essential difference in clinical features of the disease between patients in the multicase and sporadic groups. Differences between the Finnish and US series may be due to selection bias in the latter.</abstract><cop>Pisa</cop><pub>Clinical and Experimental Rheumatology</pub><pmid>11326489</pmid><tpages>3</tpages></addata></record> |
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| ispartof | Clinical and experimental rheumatology, 2001-03, Vol.19 (2), p.218-220 |
| issn | 0392-856X 1593-098X |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Age of Onset Arthritis, Juvenile - epidemiology Arthritis, Juvenile - genetics Biological and medical sciences Child Diseases of the osteoarticular system Family Health Female Finland - epidemiology Genetic Predisposition to Disease Humans Inflammatory joint diseases Male Medical sciences Prevalence United States - epidemiology |
| title | Juvenile idiopathic arthritis in multicase families |
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