Suppression of PPN MG61 attenuates Wnt β-catenin signaling pathway and induces apoptosis in human lung cancer

Wingless and int homologue (Wnt) family proteins have been shown to have important roles in the decision of cell fate and behavior at multiple stages during the development and tumorigenesis. One of the Drosophila segment polarity genes, porcupine ( porc ) gene, encodes an evolutionarily conserved e...

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Veröffentlicht in:	Oncogene 2008-05, Vol.27 (24), p.3483-3488
Hauptverfasser:	Chen, Z, Li, J, Li, Q S, Fan, J Q, Dong, X M, Xu, J P, Wang, X M, Yang, G W, Yan, P, Wen, G Z, Zhang, Y T, Niu, R G, Nan, P H, He, J, Zhou, H M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyltransferases Ageing, cell death Apoptosis beta Catenin - metabolism Biological and medical sciences Care and treatment Causes of Cell Biology Cell fate Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cells, Cultured Cellular signal transduction Drosophila Endoplasmic reticulum Fundamental and applied biological sciences. Psychology Genetic aspects Human Genetics Humans Insects Internal Medicine Lung - metabolism Lung - pathology Lung cancer Lung Neoplasms - metabolism Lung Neoplasms - pathology Medical sciences Medicine Medicine & Public Health Membrane proteins Membrane Proteins - antagonists & inhibitors Membrane Proteins - metabolism Molecular and cellular biology mRNA Oncology Physiological aspects Pneumology Polarity Post-translation Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Small Interfering - pharmacology short-communication Signal Transduction siRNA Translation Tumor cell lines Tumorigenesis Tumors of the respiratory system and mediastinum Wnt protein Wnt Proteins - metabolism β-Catenin
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