Senile Plaques in an Aged Western Lowland Gorilla
Senile plaques (SPs) were found in the cerebral cortex of a 44-year-old Western lowland gorilla (Gorilla gorilla gorilla). All the SPs were obtained as dense assemblies consisting of fibrous materials by silver impregnation, but were not detected by Congo red. More SPs were detected by immunostainin...
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| Veröffentlicht in: | Experimental Animals 2001, Vol.50(1), pp.77-81 |
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| container_title | Experimental Animals |
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| creator | KIMURA, Nobuyuki NAKAMURA, Shinichiro GOTO, Naoaki NARUSHIMA, Etsuo HARA, Itsuko SHICHIRI, Shigemi SAITOU, Kazuo NOSE, Masao HAYASHI, Takako KAWAMURA, Seiji YOSHIKAWA, Yasuhiro |
| description | Senile plaques (SPs) were found in the cerebral cortex of a 44-year-old Western lowland gorilla (Gorilla gorilla gorilla). All the SPs were obtained as dense assemblies consisting of fibrous materials by silver impregnation, but were not detected by Congo red. More SPs were detected by immunostaining for amyloidb protein (Aβ) and a half of Aβ-positive-SPs were also immunoreactive for apolipoprotein E. Moreover, all SPs were immunoreactive for Aβ 42 and Aβ 43, but not for Aβ 40. SPs also did not contain Aβ precursor protein-positive structures. These findings suggested that SPs in this case were diffuse plaques. To our knowledge, this is the first report of SPs in the gorilla. |
| doi_str_mv | 10.1538/expanim.50.77 |
| format | Article |
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All the SPs were obtained as dense assemblies consisting of fibrous materials by silver impregnation, but were not detected by Congo red. More SPs were detected by immunostaining for amyloidb protein (Aβ) and a half of Aβ-positive-SPs were also immunoreactive for apolipoprotein E. Moreover, all SPs were immunoreactive for Aβ 42 and Aβ 43, but not for Aβ 40. SPs also did not contain Aβ precursor protein-positive structures. These findings suggested that SPs in this case were diffuse plaques. To our knowledge, this is the first report of SPs in the gorilla.</description><identifier>ISSN: 1341-1357</identifier><identifier>EISSN: 1881-7122</identifier><identifier>DOI: 10.1538/expanim.50.77</identifier><identifier>PMID: 11326427</identifier><language>eng</language><publisher>Japan: Japanese Association for Laboratory Animal Science</publisher><subject>Aging ; Amyloid beta-Peptides - analysis ; amyloidβ protein ; Animals ; Apolipoproteins E - analysis ; Cerebral Cortex - ultrastructure ; gorilla ; Gorilla gorilla - anatomy & histology ; Immunohistochemistry ; Male ; Plaque, Amyloid - chemistry ; Plaque, Amyloid - ultrastructure ; senile plaque ; Silver Staining</subject><ispartof>Experimental Animals, 2001, Vol.50(1), pp.77-81</ispartof><rights>2001 Japanese Association for Laboratory Animal Science</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c535t-28d26e07546f04caee3e33ca351a6b2b8c635bd555753e3620d397751dc06ed93</citedby><cites>FETCH-LOGICAL-c535t-28d26e07546f04caee3e33ca351a6b2b8c635bd555753e3620d397751dc06ed93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11326427$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KIMURA, Nobuyuki</creatorcontrib><creatorcontrib>NAKAMURA, Shinichiro</creatorcontrib><creatorcontrib>GOTO, Naoaki</creatorcontrib><creatorcontrib>NARUSHIMA, Etsuo</creatorcontrib><creatorcontrib>HARA, Itsuko</creatorcontrib><creatorcontrib>SHICHIRI, Shigemi</creatorcontrib><creatorcontrib>SAITOU, Kazuo</creatorcontrib><creatorcontrib>NOSE, Masao</creatorcontrib><creatorcontrib>HAYASHI, Takako</creatorcontrib><creatorcontrib>KAWAMURA, Seiji</creatorcontrib><creatorcontrib>YOSHIKAWA, Yasuhiro</creatorcontrib><title>Senile Plaques in an Aged Western Lowland Gorilla</title><title>Experimental Animals</title><addtitle>Exp Anim</addtitle><description>Senile plaques (SPs) were found in the cerebral cortex of a 44-year-old Western lowland gorilla (Gorilla gorilla gorilla). All the SPs were obtained as dense assemblies consisting of fibrous materials by silver impregnation, but were not detected by Congo red. More SPs were detected by immunostaining for amyloidb protein (Aβ) and a half of Aβ-positive-SPs were also immunoreactive for apolipoprotein E. Moreover, all SPs were immunoreactive for Aβ 42 and Aβ 43, but not for Aβ 40. SPs also did not contain Aβ precursor protein-positive structures. These findings suggested that SPs in this case were diffuse plaques. To our knowledge, this is the first report of SPs in the gorilla.</description><subject>Aging</subject><subject>Amyloid beta-Peptides - analysis</subject><subject>amyloidβ protein</subject><subject>Animals</subject><subject>Apolipoproteins E - analysis</subject><subject>Cerebral Cortex - ultrastructure</subject><subject>gorilla</subject><subject>Gorilla gorilla - anatomy & histology</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Plaque, Amyloid - chemistry</subject><subject>Plaque, Amyloid - ultrastructure</subject><subject>senile plaque</subject><subject>Silver Staining</subject><issn>1341-1357</issn><issn>1881-7122</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkM1Lw0AUxBdRbK0evUpO3lL3I7svPdaiVSgoqHhcNruvNSXZ1N0U9b83JaV6efNgfgzDEHLJ6JhJkd_g98b4sh5LOgY4IkOW5ywFxvlx94uMpUxIGJCzGNeUcgA-OSUDxgRXGYchYS_oywqT58p8bjEmpU-MT6YrdMk7xhaDTxbNV2W8S-ZNKKvKnJOTpakiXux1RN7u715nD-niaf44my5SK4VsU547rpCCzNSSZtYgChTCGiGZUQUvcquELJyUEmTnKE6dmABI5ixV6CZiRK773E1odtVaXZfRYtfAY7ONGiiAynnWgWkP2tDEGHCpN6GsTfjRjOrdRnq_kZZUA3T81T54W9To_uj9KB1w2wPr2JoVHgAT2tJW-D-O9QfgYNoPEzR68Qtd2XpX</recordid><startdate>2001</startdate><enddate>2001</enddate><creator>KIMURA, Nobuyuki</creator><creator>NAKAMURA, Shinichiro</creator><creator>GOTO, Naoaki</creator><creator>NARUSHIMA, Etsuo</creator><creator>HARA, Itsuko</creator><creator>SHICHIRI, Shigemi</creator><creator>SAITOU, Kazuo</creator><creator>NOSE, Masao</creator><creator>HAYASHI, Takako</creator><creator>KAWAMURA, Seiji</creator><creator>YOSHIKAWA, Yasuhiro</creator><general>Japanese Association for Laboratory Animal Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2001</creationdate><title>Senile Plaques in an Aged Western Lowland Gorilla</title><author>KIMURA, Nobuyuki ; NAKAMURA, Shinichiro ; GOTO, Naoaki ; NARUSHIMA, Etsuo ; HARA, Itsuko ; SHICHIRI, Shigemi ; SAITOU, Kazuo ; NOSE, Masao ; HAYASHI, Takako ; KAWAMURA, Seiji ; YOSHIKAWA, Yasuhiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c535t-28d26e07546f04caee3e33ca351a6b2b8c635bd555753e3620d397751dc06ed93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Aging</topic><topic>Amyloid beta-Peptides - analysis</topic><topic>amyloidβ protein</topic><topic>Animals</topic><topic>Apolipoproteins E - analysis</topic><topic>Cerebral Cortex - ultrastructure</topic><topic>gorilla</topic><topic>Gorilla gorilla - anatomy & histology</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Plaque, Amyloid - chemistry</topic><topic>Plaque, Amyloid - ultrastructure</topic><topic>senile plaque</topic><topic>Silver Staining</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KIMURA, Nobuyuki</creatorcontrib><creatorcontrib>NAKAMURA, Shinichiro</creatorcontrib><creatorcontrib>GOTO, Naoaki</creatorcontrib><creatorcontrib>NARUSHIMA, Etsuo</creatorcontrib><creatorcontrib>HARA, Itsuko</creatorcontrib><creatorcontrib>SHICHIRI, Shigemi</creatorcontrib><creatorcontrib>SAITOU, Kazuo</creatorcontrib><creatorcontrib>NOSE, Masao</creatorcontrib><creatorcontrib>HAYASHI, Takako</creatorcontrib><creatorcontrib>KAWAMURA, Seiji</creatorcontrib><creatorcontrib>YOSHIKAWA, Yasuhiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental Animals</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KIMURA, Nobuyuki</au><au>NAKAMURA, Shinichiro</au><au>GOTO, Naoaki</au><au>NARUSHIMA, Etsuo</au><au>HARA, Itsuko</au><au>SHICHIRI, Shigemi</au><au>SAITOU, Kazuo</au><au>NOSE, Masao</au><au>HAYASHI, Takako</au><au>KAWAMURA, Seiji</au><au>YOSHIKAWA, Yasuhiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Senile Plaques in an Aged Western Lowland Gorilla</atitle><jtitle>Experimental Animals</jtitle><addtitle>Exp Anim</addtitle><date>2001</date><risdate>2001</risdate><volume>50</volume><issue>1</issue><spage>77</spage><epage>81</epage><pages>77-81</pages><issn>1341-1357</issn><eissn>1881-7122</eissn><abstract>Senile plaques (SPs) were found in the cerebral cortex of a 44-year-old Western lowland gorilla (Gorilla gorilla gorilla). All the SPs were obtained as dense assemblies consisting of fibrous materials by silver impregnation, but were not detected by Congo red. More SPs were detected by immunostaining for amyloidb protein (Aβ) and a half of Aβ-positive-SPs were also immunoreactive for apolipoprotein E. Moreover, all SPs were immunoreactive for Aβ 42 and Aβ 43, but not for Aβ 40. SPs also did not contain Aβ precursor protein-positive structures. These findings suggested that SPs in this case were diffuse plaques. To our knowledge, this is the first report of SPs in the gorilla.</abstract><cop>Japan</cop><pub>Japanese Association for Laboratory Animal Science</pub><pmid>11326427</pmid><doi>10.1538/expanim.50.77</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aging Amyloid beta-Peptides - analysis amyloidβ protein Animals Apolipoproteins E - analysis Cerebral Cortex - ultrastructure gorilla Gorilla gorilla - anatomy & histology Immunohistochemistry Male Plaque, Amyloid - chemistry Plaque, Amyloid - ultrastructure senile plaque Silver Staining |
| title | Senile Plaques in an Aged Western Lowland Gorilla |
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