Abnormal development of the sinuatrial venous valve and posterior hindbrain may contribute to late fetal resorption of vitamin A-deficient rat embryos

Background Normal embryonic development and survival in utero is dependent on an adequate supply of vitamin A. Embryos from vitamin A‐deficient (VAD) pregnant rats fed an inadequate amount of all‐trans retinoic acid (atRA; 12 μg per g of diet or ∼230 μg per rat per day) exhibit severe developmental...

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Veröffentlicht in:	Teratology (Philadelphia) 2000-12, Vol.62 (6), p.374-384
Hauptverfasser:	White, Jeffrey C., Highland, Margaret, Clagett-Dame, Margaret
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities, Multiple - etiology Abnormalities, Multiple - prevention & control Animal Feed Animals Biological and medical sciences Cranial Nerves - abnormalities Cranial Nerves - embryology Dose-Response Relationship, Drug Embryology: invertebrates and vertebrates. Teratology Embryonic and Fetal Development - drug effects Female Fetal Death - etiology Fetal Death - prevention & control Fetal Heart - drug effects Fetal Resorption - etiology Fetal Resorption - prevention & control Fundamental and applied biological sciences. Psychology Gastrula - drug effects Genes, Homeobox Gestational Age Morphogenesis - drug effects Pregnancy Pregnancy Complications - blood Pregnancy Complications - physiopathology Rats Rhombencephalon - abnormalities Rhombencephalon - embryology Teratology. Teratogens Transcription Factors - genetics Tretinoin - administration & dosage Tretinoin - therapeutic use Veins - abnormalities Veins - embryology Vitamin A - administration & dosage Vitamin A - analogs & derivatives Vitamin A - therapeutic use Vitamin A Deficiency - blood Vitamin A Deficiency - physiopathology
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