Effects of Angiotensin Converting Enzyme Inhibitor and Angiotensin II Receptor Antagonist Combination on Nitric Oxide Bioavailability and Atherosclerotic Change in Watanabe Heritable Hyperlipidemic Rabbits

We investigated the effects of co-administration of an angiotensin-converting enzyme inhibitor (ACEI) and angiotensin type 1 receptor blocker (ARB) on nitric oxide (NO) bioavailability in genetically hyperlipidemic rabbits with our newly developed NO sensor. Plasma NO was measured using the new NO s...

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Veröffentlicht in:	Hypertension research 2008-03, Vol.31 (3), p.575-584
Hauptverfasser:	Imanishi, Toshio, Kuroi, Akio, Ikejima, Hideyuki, Kobayashi, Katsunobu, Muragaki, Yasuteru, Mochizuki, Seiichi, Goto, Masami, Yoshida, Kiyoshi, Akasaka, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Angiotensin II Type 1 Receptor Blockers - pharmacology Angiotensin-Converting Enzyme Inhibitors - pharmacology Animals Aorta, Abdominal - drug effects Aorta, Abdominal - metabolism Aorta, Abdominal - pathology Atherosclerosis - metabolism Atherosclerosis - pathology Atherosclerosis - prevention & control Blood Pressure - drug effects Blood Pressure - physiology Disease Models, Animal Dose-Response Relationship, Drug Enalapril - pharmacology Heart Rate - drug effects Heart Rate - physiology Hyperlipidemias - genetics Hyperlipidemias - metabolism Losartan - pharmacology Male Nitric Oxide - metabolism Peroxynitrous Acid - blood Rabbits Tyrosine - analogs & derivatives Tyrosine - blood Vasodilator Agents - pharmacology
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