Inhibitory synaptic interactions between cochlear nuclei: Evidence from an in vitro whole brain study
USING guinea-pig isolated whole brain preparation in vitro, synaptic responses to electrical stimulation of auditory nerves were examined in intracellularly recorded and stained neurons of posteroventral and dorsal divisions of the cochlear nucleus. Stimulation of the contralateral auditory nerve ev...
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| Veröffentlicht in: | Neuroreport 1999-06, Vol.10 (9), p.1913-1917 |
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| container_issue | 9 |
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| container_title | Neuroreport |
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| creator | Babalian, Alexander L Ryugo, David K Vischer, Mattheus W Rouiller, Eric M |
| description | USING guinea-pig isolated whole brain preparation in vitro, synaptic responses to electrical stimulation of auditory nerves were examined in intracellularly recorded and stained neurons of posteroventral and dorsal divisions of the cochlear nucleus. Stimulation of the contralateral auditory nerve evoked exclusively IPSPs in 70% of neurons, with amplitude of 2.3 ± 1.2 mV. Neurons of all major cell types were inhibited from the contralateral side. In the majority of responding cells (78%) IPSPs were induced at latencies of 3–9 ms suggesting di- and trisynaptic connections from contralateral auditory afferents or, respectively, mono- and disynaptic connections from the contralateral cochlear nucleus. Few cells responded with long-latency IPSPs (13.5–23 ms), indicating involvement of polysynaptic pathways. These data demonstrate the existence of functional, direct and indirect inhibitory connections between the cochlear nuclei. |
| doi_str_mv | 10.1097/00001756-199906230-00022 |
| format | Article |
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Stimulation of the contralateral auditory nerve evoked exclusively IPSPs in 70% of neurons, with amplitude of 2.3 ± 1.2 mV. Neurons of all major cell types were inhibited from the contralateral side. In the majority of responding cells (78%) IPSPs were induced at latencies of 3–9 ms suggesting di- and trisynaptic connections from contralateral auditory afferents or, respectively, mono- and disynaptic connections from the contralateral cochlear nucleus. Few cells responded with long-latency IPSPs (13.5–23 ms), indicating involvement of polysynaptic pathways. 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Stimulation of the contralateral auditory nerve evoked exclusively IPSPs in 70% of neurons, with amplitude of 2.3 ± 1.2 mV. Neurons of all major cell types were inhibited from the contralateral side. In the majority of responding cells (78%) IPSPs were induced at latencies of 3–9 ms suggesting di- and trisynaptic connections from contralateral auditory afferents or, respectively, mono- and disynaptic connections from the contralateral cochlear nucleus. Few cells responded with long-latency IPSPs (13.5–23 ms), indicating involvement of polysynaptic pathways. These data demonstrate the existence of functional, direct and indirect inhibitory connections between the cochlear nuclei.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Size</subject><subject>Cochlear Nerve - physiology</subject><subject>Cochlear Nucleus - cytology</subject><subject>Cochlear Nucleus - physiology</subject><subject>Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation</subject><subject>Electric Stimulation</subject><subject>Evoked Potentials, Auditory - physiology</subject><subject>Excitatory Postsynaptic Potentials - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Guinea Pigs</subject><subject>Neural Inhibition - physiology</subject><subject>Neurons - cytology</subject><subject>Neurons - physiology</subject><subject>Organ Culture Techniques</subject><subject>Reaction Time - physiology</subject><subject>Staining and Labeling</subject><subject>Synaptic Transmission - physiology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1P3DAQhq2qVVmgf6Hyoeot4I84jrlViLZISFyoxM1ynIni1mtvbYfV_vsadgtcmMtIo-edkZ5BCFNyRomS56QWlaJrqFKKdIyTpk4Ye4dWtJW8EaK_f49WRAnVtKoTR-g4598VUYT2H9ERJYJQwdkKwXWY3eBKTDucd8FsirPYhQLJ2OJiyHiAsgUI2EY7ezAJh8V6cBf46sGNECzgKcU1NqHG8IMrKeLtHD3gIZk6yWUZd6fow2R8hk-HfoJ-fb-6u_zZ3Nz-uL78dtNYzglrBmYFMSMZbU9BDKylxCopJiY5m5hQ_Ui6gbe8A0MNb4XtYKCyBTl2SvXM8BP0db93k-LfBXLRa5cteG8CxCVrSaRsiWQV7PegTTHnBJPeJLc2aacp0Y-K9X_F-lmxflJco58PN5ZhDeOr4N5pBb4cAJOt8VMywbr8wvWKy05UrN1j2-ir7vzHL1tIegbjy6zf-jD_B1IEk98</recordid><startdate>19990623</startdate><enddate>19990623</enddate><creator>Babalian, Alexander L</creator><creator>Ryugo, David K</creator><creator>Vischer, Mattheus W</creator><creator>Rouiller, Eric M</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990623</creationdate><title>Inhibitory synaptic interactions between cochlear nuclei: Evidence from an in vitro whole brain study</title><author>Babalian, Alexander L ; Ryugo, David K ; Vischer, Mattheus W ; Rouiller, Eric M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3302-b2c50ad0dc81e5b2410c975f2732f2598d06b3436ea1a345c6eb174e7d69982a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Size</topic><topic>Cochlear Nerve - physiology</topic><topic>Cochlear Nucleus - cytology</topic><topic>Cochlear Nucleus - physiology</topic><topic>Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation</topic><topic>Electric Stimulation</topic><topic>Evoked Potentials, Auditory - physiology</topic><topic>Excitatory Postsynaptic Potentials - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Guinea Pigs</topic><topic>Neural Inhibition - physiology</topic><topic>Neurons - cytology</topic><topic>Neurons - physiology</topic><topic>Organ Culture Techniques</topic><topic>Reaction Time - physiology</topic><topic>Staining and Labeling</topic><topic>Synaptic Transmission - physiology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Babalian, Alexander L</creatorcontrib><creatorcontrib>Ryugo, David K</creatorcontrib><creatorcontrib>Vischer, Mattheus W</creatorcontrib><creatorcontrib>Rouiller, Eric M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Babalian, Alexander L</au><au>Ryugo, David K</au><au>Vischer, Mattheus W</au><au>Rouiller, Eric M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibitory synaptic interactions between cochlear nuclei: Evidence from an in vitro whole brain study</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>1999-06-23</date><risdate>1999</risdate><volume>10</volume><issue>9</issue><spage>1913</spage><epage>1917</epage><pages>1913-1917</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>USING guinea-pig isolated whole brain preparation in vitro, synaptic responses to electrical stimulation of auditory nerves were examined in intracellularly recorded and stained neurons of posteroventral and dorsal divisions of the cochlear nucleus. Stimulation of the contralateral auditory nerve evoked exclusively IPSPs in 70% of neurons, with amplitude of 2.3 ± 1.2 mV. Neurons of all major cell types were inhibited from the contralateral side. In the majority of responding cells (78%) IPSPs were induced at latencies of 3–9 ms suggesting di- and trisynaptic connections from contralateral auditory afferents or, respectively, mono- and disynaptic connections from the contralateral cochlear nucleus. Few cells responded with long-latency IPSPs (13.5–23 ms), indicating involvement of polysynaptic pathways. These data demonstrate the existence of functional, direct and indirect inhibitory connections between the cochlear nuclei.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>10501532</pmid><doi>10.1097/00001756-199906230-00022</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Biological and medical sciences Cell Size Cochlear Nerve - physiology Cochlear Nucleus - cytology Cochlear Nucleus - physiology Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation Electric Stimulation Evoked Potentials, Auditory - physiology Excitatory Postsynaptic Potentials - physiology Fundamental and applied biological sciences. Psychology Guinea Pigs Neural Inhibition - physiology Neurons - cytology Neurons - physiology Organ Culture Techniques Reaction Time - physiology Staining and Labeling Synaptic Transmission - physiology Vertebrates: nervous system and sense organs |
| title | Inhibitory synaptic interactions between cochlear nuclei: Evidence from an in vitro whole brain study |
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