A Kinetic, Spectroscopic, and Redox Study of Human Tryptophan 2,3-Dioxygenase

The family of heme dioxygenases, as exemplified by indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase, catalyzes the oxidative cleavage of l-tryptophan to N-formylkynurenine. Here, we describe a bacterial expression system for human tryptophan 2,3-dioxygenase (rhTDO) together with spectrosco...

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Veröffentlicht in:	Biochemistry (Easton) 2008-04, Vol.47 (16), p.4752-4760
Hauptverfasser:	Basran, Jaswir, Rafice, Sara A, Chauhan, Nishma, Efimov, Igor, Cheesman, Myles R, Ghamsari, Lila, Raven, Emma Lloyd
Format:	Artikel
Sprache:	eng
Schlagworte:	Electrons Gene Expression Humans Iron - metabolism Kinetics Ligands Molecular Structure Oxidation-Reduction Oxygen - metabolism Potentiometry Protein Binding Spectrophotometry Tryptophan - chemistry Tryptophan - metabolism Tryptophan Oxygenase - chemistry Tryptophan Oxygenase - genetics Tryptophan Oxygenase - isolation & purification Tryptophan Oxygenase - metabolism
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