Transcriptional induction of bilirubin UDP-glucuronosyltransrase by ethanol in rat liver

Several drug-metabolizing enzymes including bilirubin UDP-glucuronosyltransferase (UGT1A1) are influenced by long-term ethanol consumption. In the present study, the activity and expression of UGT1A1 were investigated in livers of ethanol-treated rats. Animals were treated daily for 15 days with eth...

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Veröffentlicht in:	Alcohol (Fayetteville, N.Y.) N.Y.), 2000-07, Vol.21 (3), p.251-257
Hauptverfasser:	Kardon, Tamás, Coffey, Marcus Jonathan, Bánhegyi, Gábor, Conley, Abigail Ann, Burchell, Brian, Mandl, József, Braun, László
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bilirubin Bilirubin - metabolism Central Nervous System Depressants - pharmacology Cytochrome P-450 CYP2E1 - drug effects Cytochrome P-450 CYP2E1 - metabolism Enzyme Induction - drug effects Ethanol Ethanol - pharmacology Glucuronidation Glucuronosyltransferase - drug effects Glucuronosyltransferase - metabolism Liver Male Microsomes, Liver - drug effects Microsomes, Liver - metabolism Rats Rats, Wistar RNA, Messenger - drug effects RNA, Messenger - metabolism Transcription, Genetic - drug effects Transcription, Genetic - physiology
Online-Zugang:	Volltext
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