The nonadrenergic noncholinergic-mediated relaxation of corpus cavernosum was impaired in chronic lithium-treated rats: Improvement with l-arginine
One-third of lithium-treated men complain from sexual dysfunction, although the exact mechanisms of which are not yet known. In this study we investigated the effect of chronic lithium (LiCl, 600 mg/l for 30 days) administration on the neurogenic relaxation of isolated rat corpus cavernosum. The cor...
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| Veröffentlicht in: | European journal of pharmacology 2008-05, Vol.586 (1), p.300-305 |
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| creator | Sadeghipour, Hamed Dehghani, Mehdi Ghasemi, Mehdi Riazi, Kiarash Asadi, Shahrzad Ebrahimi, Farzad Honar, Hooman Hajrasouliha, Amir Reza Tavakoli, Sina Sianati, Setareh Dehpour, Ahmad Reza |
| description | One-third of lithium-treated men complain from sexual dysfunction, although the exact mechanisms of which are not yet known. In this study we investigated the effect of chronic lithium (LiCl, 600 mg/l for 30 days) administration on the neurogenic relaxation of isolated rat corpus cavernosum. The corporal strips were precontracted with phenylephrine and electrical field stimulation (EFS) was applied to obtain relaxation. Relaxation to EFS was significantly (
P
<
0.001) impaired in LiCl-treated rats. The nitric oxide (NO) synthase inhibitor
N
ω
-nitro-
l-arginine methyl ester (
l-NAME; 100 µM) inhibited the relaxation to EFS in both LiCl-treated and control rats. The NO precursor
l-arginine, at per se noneffective concentration (0.1 mM), significantly (
P
<
0.001) enhanced the EFS-induced relaxation of LiCl-treated corporal strips. The relaxation responses to the NO donor sodium nitroprusside were similar between two groups. These data demonstrate that chronic lithium treatment could impair the NO-mediated neurogenic relaxation of rat corpus cavernosum which could be prevented by
l-arginine. |
| doi_str_mv | 10.1016/j.ejphar.2008.02.054 |
| format | Article |
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P
<
0.001) impaired in LiCl-treated rats. The nitric oxide (NO) synthase inhibitor
N
ω
-nitro-
l-arginine methyl ester (
l-NAME; 100 µM) inhibited the relaxation to EFS in both LiCl-treated and control rats. The NO precursor
l-arginine, at per se noneffective concentration (0.1 mM), significantly (
P
<
0.001) enhanced the EFS-induced relaxation of LiCl-treated corporal strips. The relaxation responses to the NO donor sodium nitroprusside were similar between two groups. These data demonstrate that chronic lithium treatment could impair the NO-mediated neurogenic relaxation of rat corpus cavernosum which could be prevented by
l-arginine.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/j.ejphar.2008.02.054</identifier><identifier>PMID: 18374915</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Arginine - pharmacology ; Autonomic Nervous System - physiology ; Corpus cavernosum ; Cyclooxygenase Inhibitors - pharmacology ; Dose-Response Relationship, Drug ; Electric Stimulation ; Enzyme Inhibitors - pharmacology ; Erectile dysfunction ; In Vitro Techniques ; Indomethacin - pharmacology ; l-arginine ; Lithium ; Lithium Chloride - pharmacology ; Male ; Muscle Relaxation - drug effects ; Muscle, Smooth, Vascular - drug effects ; NG-Nitroarginine Methyl Ester - pharmacology ; Nitric Oxide - physiology ; Nitric oxide [NO] ; Nitric Oxide Synthase - antagonists & inhibitors ; Nitroprusside - pharmacology ; Nonadrenergic noncholinergic [NANC] relaxation ; Penis - blood supply ; Penis - physiology ; Phenylephrine - pharmacology ; Rats ; Regional Blood Flow - drug effects ; Vasoconstrictor Agents - pharmacology ; Vasodilator Agents - pharmacology</subject><ispartof>European journal of pharmacology, 2008-05, Vol.586 (1), p.300-305</ispartof><rights>2008 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-d41d86e2ede6fe6b25fe8bb95c2f318e12b5e8937a0848547eb19cda4b34dca13</citedby><cites>FETCH-LOGICAL-c360t-d41d86e2ede6fe6b25fe8bb95c2f318e12b5e8937a0848547eb19cda4b34dca13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejphar.2008.02.054$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18374915$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sadeghipour, Hamed</creatorcontrib><creatorcontrib>Dehghani, Mehdi</creatorcontrib><creatorcontrib>Ghasemi, Mehdi</creatorcontrib><creatorcontrib>Riazi, Kiarash</creatorcontrib><creatorcontrib>Asadi, Shahrzad</creatorcontrib><creatorcontrib>Ebrahimi, Farzad</creatorcontrib><creatorcontrib>Honar, Hooman</creatorcontrib><creatorcontrib>Hajrasouliha, Amir Reza</creatorcontrib><creatorcontrib>Tavakoli, Sina</creatorcontrib><creatorcontrib>Sianati, Setareh</creatorcontrib><creatorcontrib>Dehpour, Ahmad Reza</creatorcontrib><title>The nonadrenergic noncholinergic-mediated relaxation of corpus cavernosum was impaired in chronic lithium-treated rats: Improvement with l-arginine</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>One-third of lithium-treated men complain from sexual dysfunction, although the exact mechanisms of which are not yet known. In this study we investigated the effect of chronic lithium (LiCl, 600 mg/l for 30 days) administration on the neurogenic relaxation of isolated rat corpus cavernosum. The corporal strips were precontracted with phenylephrine and electrical field stimulation (EFS) was applied to obtain relaxation. Relaxation to EFS was significantly (
P
<
0.001) impaired in LiCl-treated rats. The nitric oxide (NO) synthase inhibitor
N
ω
-nitro-
l-arginine methyl ester (
l-NAME; 100 µM) inhibited the relaxation to EFS in both LiCl-treated and control rats. The NO precursor
l-arginine, at per se noneffective concentration (0.1 mM), significantly (
P
<
0.001) enhanced the EFS-induced relaxation of LiCl-treated corporal strips. The relaxation responses to the NO donor sodium nitroprusside were similar between two groups. These data demonstrate that chronic lithium treatment could impair the NO-mediated neurogenic relaxation of rat corpus cavernosum which could be prevented by
l-arginine.</description><subject>Animals</subject><subject>Arginine - pharmacology</subject><subject>Autonomic Nervous System - physiology</subject><subject>Corpus cavernosum</subject><subject>Cyclooxygenase Inhibitors - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Electric Stimulation</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Erectile dysfunction</subject><subject>In Vitro Techniques</subject><subject>Indomethacin - pharmacology</subject><subject>l-arginine</subject><subject>Lithium</subject><subject>Lithium Chloride - pharmacology</subject><subject>Male</subject><subject>Muscle Relaxation - drug effects</subject><subject>Muscle, Smooth, Vascular - drug effects</subject><subject>NG-Nitroarginine Methyl Ester - pharmacology</subject><subject>Nitric Oxide - physiology</subject><subject>Nitric oxide [NO]</subject><subject>Nitric Oxide Synthase - antagonists & inhibitors</subject><subject>Nitroprusside - pharmacology</subject><subject>Nonadrenergic noncholinergic [NANC] relaxation</subject><subject>Penis - blood supply</subject><subject>Penis - physiology</subject><subject>Phenylephrine - pharmacology</subject><subject>Rats</subject><subject>Regional Blood Flow - drug effects</subject><subject>Vasoconstrictor Agents - pharmacology</subject><subject>Vasodilator Agents - pharmacology</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU-L1TAUxYMoznP0G4hk5a71Jv0bF4IM6gwMuBnXIU1ubR5tUpP0jX4Ov7B59IG7WYULv3tO7jmEvGVQMmDth2OJx3VSoeQAfQm8hKZ-Rg6s70QBHePPyQGA1QUXQlyRVzEeAaARvHlJrlhfdbVgzYH8fZiQOu-UCegw_LT6POnJz3YfiwWNVQkNDTir3ypZ76gfqfZh3SLV6oTB-bgt9FFFapdV2ZBh66iegndZb7ZpsttSpIC7jkrxI71b1uBPuKBL9DETdC5U9nPZ9jV5Mao54pvLe01-fP3ycHNb3H__dnfz-b7QVQupMDUzfYscDbYjtgNvRuyHQTSajxXrkfGhwV5UnYK-7pu6w4EJbVQ9VLXRilXX5P2um3_ya8OY5GKjxnlWDv0WZQddx0FABusd1MHHGHCUa7CLCn8kA3kuQx7lXoY8lyGBy1xGXnt30d-GnOL_pUv6Gfi0A5ivPFkMMmqLTufEA-okjbdPO_wDjeSh9A</recordid><startdate>20080531</startdate><enddate>20080531</enddate><creator>Sadeghipour, Hamed</creator><creator>Dehghani, Mehdi</creator><creator>Ghasemi, Mehdi</creator><creator>Riazi, Kiarash</creator><creator>Asadi, Shahrzad</creator><creator>Ebrahimi, Farzad</creator><creator>Honar, Hooman</creator><creator>Hajrasouliha, Amir Reza</creator><creator>Tavakoli, Sina</creator><creator>Sianati, Setareh</creator><creator>Dehpour, Ahmad Reza</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080531</creationdate><title>The nonadrenergic noncholinergic-mediated relaxation of corpus cavernosum was impaired in chronic lithium-treated rats: Improvement with l-arginine</title><author>Sadeghipour, Hamed ; Dehghani, Mehdi ; Ghasemi, Mehdi ; Riazi, Kiarash ; Asadi, Shahrzad ; Ebrahimi, Farzad ; Honar, Hooman ; Hajrasouliha, Amir Reza ; Tavakoli, Sina ; Sianati, Setareh ; Dehpour, Ahmad Reza</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-d41d86e2ede6fe6b25fe8bb95c2f318e12b5e8937a0848547eb19cda4b34dca13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Arginine - pharmacology</topic><topic>Autonomic Nervous System - physiology</topic><topic>Corpus cavernosum</topic><topic>Cyclooxygenase Inhibitors - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Electric Stimulation</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Erectile dysfunction</topic><topic>In Vitro Techniques</topic><topic>Indomethacin - pharmacology</topic><topic>l-arginine</topic><topic>Lithium</topic><topic>Lithium Chloride - pharmacology</topic><topic>Male</topic><topic>Muscle Relaxation - drug effects</topic><topic>Muscle, Smooth, Vascular - drug effects</topic><topic>NG-Nitroarginine Methyl Ester - pharmacology</topic><topic>Nitric Oxide - physiology</topic><topic>Nitric oxide [NO]</topic><topic>Nitric Oxide Synthase - antagonists & inhibitors</topic><topic>Nitroprusside - pharmacology</topic><topic>Nonadrenergic noncholinergic [NANC] relaxation</topic><topic>Penis - blood supply</topic><topic>Penis - physiology</topic><topic>Phenylephrine - pharmacology</topic><topic>Rats</topic><topic>Regional Blood Flow - drug effects</topic><topic>Vasoconstrictor Agents - pharmacology</topic><topic>Vasodilator Agents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sadeghipour, Hamed</creatorcontrib><creatorcontrib>Dehghani, Mehdi</creatorcontrib><creatorcontrib>Ghasemi, Mehdi</creatorcontrib><creatorcontrib>Riazi, Kiarash</creatorcontrib><creatorcontrib>Asadi, Shahrzad</creatorcontrib><creatorcontrib>Ebrahimi, Farzad</creatorcontrib><creatorcontrib>Honar, Hooman</creatorcontrib><creatorcontrib>Hajrasouliha, Amir Reza</creatorcontrib><creatorcontrib>Tavakoli, Sina</creatorcontrib><creatorcontrib>Sianati, Setareh</creatorcontrib><creatorcontrib>Dehpour, Ahmad Reza</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sadeghipour, Hamed</au><au>Dehghani, Mehdi</au><au>Ghasemi, Mehdi</au><au>Riazi, Kiarash</au><au>Asadi, Shahrzad</au><au>Ebrahimi, Farzad</au><au>Honar, Hooman</au><au>Hajrasouliha, Amir Reza</au><au>Tavakoli, Sina</au><au>Sianati, Setareh</au><au>Dehpour, Ahmad Reza</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The nonadrenergic noncholinergic-mediated relaxation of corpus cavernosum was impaired in chronic lithium-treated rats: Improvement with l-arginine</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>2008-05-31</date><risdate>2008</risdate><volume>586</volume><issue>1</issue><spage>300</spage><epage>305</epage><pages>300-305</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><abstract>One-third of lithium-treated men complain from sexual dysfunction, although the exact mechanisms of which are not yet known. In this study we investigated the effect of chronic lithium (LiCl, 600 mg/l for 30 days) administration on the neurogenic relaxation of isolated rat corpus cavernosum. The corporal strips were precontracted with phenylephrine and electrical field stimulation (EFS) was applied to obtain relaxation. Relaxation to EFS was significantly (
P
<
0.001) impaired in LiCl-treated rats. The nitric oxide (NO) synthase inhibitor
N
ω
-nitro-
l-arginine methyl ester (
l-NAME; 100 µM) inhibited the relaxation to EFS in both LiCl-treated and control rats. The NO precursor
l-arginine, at per se noneffective concentration (0.1 mM), significantly (
P
<
0.001) enhanced the EFS-induced relaxation of LiCl-treated corporal strips. The relaxation responses to the NO donor sodium nitroprusside were similar between two groups. These data demonstrate that chronic lithium treatment could impair the NO-mediated neurogenic relaxation of rat corpus cavernosum which could be prevented by
l-arginine.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>18374915</pmid><doi>10.1016/j.ejphar.2008.02.054</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-2999 |
| ispartof | European journal of pharmacology, 2008-05, Vol.586 (1), p.300-305 |
| issn | 0014-2999 1879-0712 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Arginine - pharmacology Autonomic Nervous System - physiology Corpus cavernosum Cyclooxygenase Inhibitors - pharmacology Dose-Response Relationship, Drug Electric Stimulation Enzyme Inhibitors - pharmacology Erectile dysfunction In Vitro Techniques Indomethacin - pharmacology l-arginine Lithium Lithium Chloride - pharmacology Male Muscle Relaxation - drug effects Muscle, Smooth, Vascular - drug effects NG-Nitroarginine Methyl Ester - pharmacology Nitric Oxide - physiology Nitric oxide [NO] Nitric Oxide Synthase - antagonists & inhibitors Nitroprusside - pharmacology Nonadrenergic noncholinergic [NANC] relaxation Penis - blood supply Penis - physiology Phenylephrine - pharmacology Rats Regional Blood Flow - drug effects Vasoconstrictor Agents - pharmacology Vasodilator Agents - pharmacology |
| title | The nonadrenergic noncholinergic-mediated relaxation of corpus cavernosum was impaired in chronic lithium-treated rats: Improvement with l-arginine |
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