Trans-activator of transcription-mediated delivery of NEP1-40 protein into brain has a neuroprotective effect against focal cerebral ischemic injury via inhibition of neuronal apoptosis

The Nogo-66 antagonistic peptide (NEP1-40) is a potential candidate for therapeutic intervention of neuronal injury. However, delivery of the proteins across the blood-brain barrier is severely limited by its size and biochemical properties. The current study was designed to evaluate the transducibl...

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Veröffentlicht in:	Anesthesiology (Philadelphia) 2008-06, Vol.108 (6), p.1071-1080
Hauptverfasser:	Wang, Qiang, Gou, Xingchun, Xiong, Lize, Jin, Weilin, Chen, Shaoyang, Hou, Lichao, Xu, Lixian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Blood-Brain Barrier Blotting, Western Brain - drug effects Brain Ischemia - prevention & control Disease Models, Animal Fluorescent Antibody Technique - methods Gene Products, tat - administration & dosage Gene Products, tat - genetics Male Myelin Proteins - genetics Myelin Proteins - therapeutic use Neurons - drug effects Neuroprotective Agents - administration & dosage Neuroprotective Agents - isolation & purification Neuroprotective Agents - therapeutic use Peptide Fragments - genetics Peptide Fragments - therapeutic use Rats Rats, Sprague-Dawley Recombinant Fusion Proteins - administration & dosage Recombinant Fusion Proteins - isolation & purification Recombinant Fusion Proteins - therapeutic use
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