CpG DNA and LPS induce distinct patterns of activation in human monocytes

A specific set of immune functions is switched on in response to DNA containing unmethylated CpG dinucleotides in particular base contexts ('CpG motifs'). Plasmids, viral vectors and antisense oligodeoxynucleotides used for DNA vaccination, gene replacement or gene blockade contain immunos...

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Veröffentlicht in:	Gene therapy 1999-05, Vol.6 (5), p.893-903
Hauptverfasser:	Hartmann, G, Krieg, A M
Format:	Artikel
Sprache:	eng
Schlagworte:	Antisense DNA Antisense oligonucleotides Biological activity Calf thymus Cell activation Cells, Cultured CpG islands CpG Islands - genetics Cytokines - analysis Cytokines - metabolism DNA biosynthesis DNA vaccines E coli Enzyme-linked immunosorbent assay Enzyme-Linked Immunosorbent Assay - methods Escherichia coli Flow Cytometry Genetic Therapy - methods Humans Immune response Immunostimulation Intercellular adhesion molecule 1 Interleukin 6 Interleukin-6 - analysis Interleukin-6 - metabolism Leukocytes Leukocytes, Mononuclear - immunology Lipopolysaccharides Lipopolysaccharides - pharmacology Lymphocyte Activation Monocytes Oligonucleotides Peripheral blood mononuclear cells Plasmids Tumor necrosis factor Tumor Necrosis Factor-alpha - analysis Tumor Necrosis Factor-alpha - metabolism Vaccination Vaccines, DNA - pharmacology
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