Molecular Rotor Measures Viscosity of Live Cells via Fluorescence Lifetime Imaging

The fluorescence intensity and lifetime of the 4,4′-difluoro-4-bora-5-(p-oxoalkyl)phenyl-3a,4a-diaza-s-indacene (1) show a strong correlation with the viscosity of the medium due to the viscosity-dependent twisting of the 5-phenyl group, which gives access to the dark nonemissive excited state. We p...

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Veröffentlicht in:	Journal of the American Chemical Society 2008-05, Vol.130 (21), p.6672-6673
Hauptverfasser:	Kuimova, Marina K, Yahioglu, Gokhan, Levitt, James A, Suhling, Klaus
Format:	Artikel
Sprache:	eng
Schlagworte:	Boron Compounds - chemistry Calibration Cell Line, Tumor Fluorescence Polarization Fluorescent Dyes - chemistry Humans Microscopy, Fluorescence Spectrometry, Fluorescence - methods Viscosity
Online-Zugang:	Volltext
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