Ascochytatin, a Novel Bioactive Spirodioxynaphthalene Metabolite Produced by the Marine-derived Fungus, Ascochyta sp. NGB4

Ascochytatin, a new spirodioxynaphthalene metabolite produced by a marine-derived fungus, was found from a screening program focused on the bacterial two-component regulatory system. The structure of ascochytatin was determined by spectroscopic methods, including NMR and MS. The relative stereochemi...

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Veröffentlicht in:	Journal of antibiotics 2008-03, Vol.61 (3), p.142-148
Hauptverfasser:	Kanoh, Kaneo, Okada, Ario, Adachi, Kyoko, Imagawa, Hiroshi, Nishizawa, Mugio, Matsuda, Satoru, Shizuri, Yoshikazu, Utsumi, Ryutaro
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antibiotics, Antineoplastic - isolation & purification Antibiotics, Antineoplastic - pharmacology Ascochyta Ascomycota - chemistry Ascomycota - classification Bacillus subtilis - drug effects Bacteria - drug effects Bacteriology Biomedical and Life Sciences Bioorganic Chemistry Cell Line, Tumor Chemical Phenomena Chemistry, Physical Chromatography, Thin Layer Crystallography, X-Ray Culture Media Humans Life Sciences Magnetic Resonance Spectroscopy Medicinal Chemistry Metabolites Microbial Sensitivity Tests Microbiology Models, Molecular Naphthalenes - chemistry Naphthalenes - isolation & purification Naphthalenes - pharmacology Organic Chemistry original-article Spectrometry, Mass, Electrospray Ionization Spectrometry, Mass, Fast Atom Bombardment Spectrophotometry, Infrared Spectrophotometry, Ultraviolet Spiro Compounds - chemistry Spiro Compounds - isolation & purification Spiro Compounds - pharmacology
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Beschreibung
Zusammenfassung:	Ascochytatin, a new spirodioxynaphthalene metabolite produced by a marine-derived fungus, was found from a screening program focused on the bacterial two-component regulatory system. The structure of ascochytatin was determined by spectroscopic methods, including NMR and MS. The relative stereochemistry was determined by an X-ray crystallographic analysis, and the absolute stereochemistry was determined by the modified Mosher's method.
ISSN:	0021-8820 1881-1469
DOI:	10.1038/ja.2008.123