A case of subcutaneous Mycoleptodiscus indicus infection in a liver transplant recipient successfully treated with antifungal therapy
: Mycoleptodiscus indicus, a dematiaceous mold, occurs on the leaves of a number of different host plants and has been only recently described as a cause of human infection. Immunosuppressed individuals are at risk for developing infections with opportunistic fungal pathogens, which are a major caus...
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| Veröffentlicht in: | Transplant infectious disease 2008-06, Vol.10 (3), p.218-220 |
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| container_title | Transplant infectious disease |
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| creator | Garrison, A.P. Procop, G.W. Vincek, V. Moon, J. Morris, M.I. Doblecki‐Lewis, S. Cleary, T.J. Brust, D. Rosa‐Cunha, I. |
| description | : Mycoleptodiscus indicus, a dematiaceous mold, occurs on the leaves of a number of different host plants and has been only recently described as a cause of human infection. Immunosuppressed individuals are at risk for developing infections with opportunistic fungal pathogens, which are a major cause of morbidity and mortality in this population. In addition, the treatment of infections caused by these fungi is frequently challenging. We report a case of M. indicus subcutaneous infection in a 51‐year‐old man with human immunodeficiency virus and hepatitis C co‐infection, who had a liver transplant. He developed skin nodules with a sporotrichoid lymphangitic distribution. Histopathology demonstrated unusual fungal elements with angioinvasion. Mycology cultures isolated a dematiaceous mold with the characteristic curved hyaline conidia of M. indicus. Initial treatment involved a combination of amphotericin B lipid complex and voriconazole, followed by monotherapy with voriconazole. The subcutaneous lesions resolved completely after 4 months of antifungal therapy. |
| doi_str_mv | 10.1111/j.1399-3062.2007.00278.x |
| format | Article |
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Immunosuppressed individuals are at risk for developing infections with opportunistic fungal pathogens, which are a major cause of morbidity and mortality in this population. In addition, the treatment of infections caused by these fungi is frequently challenging. We report a case of M. indicus subcutaneous infection in a 51‐year‐old man with human immunodeficiency virus and hepatitis C co‐infection, who had a liver transplant. He developed skin nodules with a sporotrichoid lymphangitic distribution. Histopathology demonstrated unusual fungal elements with angioinvasion. Mycology cultures isolated a dematiaceous mold with the characteristic curved hyaline conidia of M. indicus. Initial treatment involved a combination of amphotericin B lipid complex and voriconazole, followed by monotherapy with voriconazole. The subcutaneous lesions resolved completely after 4 months of antifungal therapy.</description><identifier>ISSN: 1398-2273</identifier><identifier>EISSN: 1399-3062</identifier><identifier>DOI: 10.1111/j.1399-3062.2007.00278.x</identifier><identifier>PMID: 17944811</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>amphotericin B lipid complex ; Antifungal Agents - therapeutic use ; Dermatomycoses - drug therapy ; Dermatomycoses - etiology ; hepatitis C ; HIV ; Humans ; liver transplant ; Liver Transplantation - adverse effects ; Male ; Middle Aged ; Mitosporic Fungi ; Mycoleptodiscus indicus ; voriconazole</subject><ispartof>Transplant infectious disease, 2008-06, Vol.10 (3), p.218-220</ispartof><rights>Copyright © Blackwell Munksgaard 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3668-dc2e32cb3a9643d937cb283cf323c83d3ceec34aca3f1f21d5e063445c889f5a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1399-3062.2007.00278.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1399-3062.2007.00278.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17944811$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garrison, A.P.</creatorcontrib><creatorcontrib>Procop, G.W.</creatorcontrib><creatorcontrib>Vincek, V.</creatorcontrib><creatorcontrib>Moon, J.</creatorcontrib><creatorcontrib>Morris, M.I.</creatorcontrib><creatorcontrib>Doblecki‐Lewis, S.</creatorcontrib><creatorcontrib>Cleary, T.J.</creatorcontrib><creatorcontrib>Brust, D.</creatorcontrib><creatorcontrib>Rosa‐Cunha, I.</creatorcontrib><title>A case of subcutaneous Mycoleptodiscus indicus infection in a liver transplant recipient successfully treated with antifungal therapy</title><title>Transplant infectious disease</title><addtitle>Transpl Infect Dis</addtitle><description>: Mycoleptodiscus indicus, a dematiaceous mold, occurs on the leaves of a number of different host plants and has been only recently described as a cause of human infection. Immunosuppressed individuals are at risk for developing infections with opportunistic fungal pathogens, which are a major cause of morbidity and mortality in this population. In addition, the treatment of infections caused by these fungi is frequently challenging. We report a case of M. indicus subcutaneous infection in a 51‐year‐old man with human immunodeficiency virus and hepatitis C co‐infection, who had a liver transplant. He developed skin nodules with a sporotrichoid lymphangitic distribution. Histopathology demonstrated unusual fungal elements with angioinvasion. Mycology cultures isolated a dematiaceous mold with the characteristic curved hyaline conidia of M. indicus. Initial treatment involved a combination of amphotericin B lipid complex and voriconazole, followed by monotherapy with voriconazole. The subcutaneous lesions resolved completely after 4 months of antifungal therapy.</description><subject>amphotericin B lipid complex</subject><subject>Antifungal Agents - therapeutic use</subject><subject>Dermatomycoses - drug therapy</subject><subject>Dermatomycoses - etiology</subject><subject>hepatitis C</subject><subject>HIV</subject><subject>Humans</subject><subject>liver transplant</subject><subject>Liver Transplantation - adverse effects</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mitosporic Fungi</subject><subject>Mycoleptodiscus indicus</subject><subject>voriconazole</subject><issn>1398-2273</issn><issn>1399-3062</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcFu1DAQhiMEoqXwCsgnbgm2J5s4EpeqFKhUxKWcLe9kTL3yJsF2aPMAvDdOs4Irvvy_5W_Gmn-KggleiXzeHyoBXVcCb2QlOW8rzmWrqsdnxfnfh-dPXpVStnBWvIrxwLlou7p7WZytWishzovflwxNJDZaFuc9zskMNM6RfV1w9DSlsXcR890NvdvUEiY3Dtkxw7z7RYGlYIY4eTMkFgjd5Ci7OCNSjHb2fskEmUQ9e3DpnmXO2Xn4YTxL9xTMtLwuXljjI7056UXx_dP13dWX8vbb55ury9sSoWlU2aMkkLgH0zU19B20uJcK0IIEVNADEiHUBg1YYaXod8QbqOsdKtXZnYGL4t3Wdwrjz5li0sc8Hnm_Ta1b3jadkpBBtYEYxhgDWT0FdzRh0YLrdQX6oNek9Zq0Xlegn1agH3Pp29Mf8_5I_b_CU-YZ-LABD87T8t-N9d3Nx2zgD1f-mQ4</recordid><startdate>200806</startdate><enddate>200806</enddate><creator>Garrison, A.P.</creator><creator>Procop, G.W.</creator><creator>Vincek, V.</creator><creator>Moon, J.</creator><creator>Morris, M.I.</creator><creator>Doblecki‐Lewis, S.</creator><creator>Cleary, T.J.</creator><creator>Brust, D.</creator><creator>Rosa‐Cunha, I.</creator><general>Blackwell Publishing Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200806</creationdate><title>A case of subcutaneous Mycoleptodiscus indicus infection in a liver transplant recipient successfully treated with antifungal therapy</title><author>Garrison, A.P. ; Procop, G.W. ; Vincek, V. ; Moon, J. ; Morris, M.I. ; Doblecki‐Lewis, S. ; Cleary, T.J. ; Brust, D. ; Rosa‐Cunha, I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3668-dc2e32cb3a9643d937cb283cf323c83d3ceec34aca3f1f21d5e063445c889f5a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>amphotericin B lipid complex</topic><topic>Antifungal Agents - therapeutic use</topic><topic>Dermatomycoses - drug therapy</topic><topic>Dermatomycoses - etiology</topic><topic>hepatitis C</topic><topic>HIV</topic><topic>Humans</topic><topic>liver transplant</topic><topic>Liver Transplantation - adverse effects</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mitosporic Fungi</topic><topic>Mycoleptodiscus indicus</topic><topic>voriconazole</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garrison, A.P.</creatorcontrib><creatorcontrib>Procop, G.W.</creatorcontrib><creatorcontrib>Vincek, V.</creatorcontrib><creatorcontrib>Moon, J.</creatorcontrib><creatorcontrib>Morris, M.I.</creatorcontrib><creatorcontrib>Doblecki‐Lewis, S.</creatorcontrib><creatorcontrib>Cleary, T.J.</creatorcontrib><creatorcontrib>Brust, D.</creatorcontrib><creatorcontrib>Rosa‐Cunha, I.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplant infectious disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garrison, A.P.</au><au>Procop, G.W.</au><au>Vincek, V.</au><au>Moon, J.</au><au>Morris, M.I.</au><au>Doblecki‐Lewis, S.</au><au>Cleary, T.J.</au><au>Brust, D.</au><au>Rosa‐Cunha, I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A case of subcutaneous Mycoleptodiscus indicus infection in a liver transplant recipient successfully treated with antifungal therapy</atitle><jtitle>Transplant infectious disease</jtitle><addtitle>Transpl Infect Dis</addtitle><date>2008-06</date><risdate>2008</risdate><volume>10</volume><issue>3</issue><spage>218</spage><epage>220</epage><pages>218-220</pages><issn>1398-2273</issn><eissn>1399-3062</eissn><abstract>: Mycoleptodiscus indicus, a dematiaceous mold, occurs on the leaves of a number of different host plants and has been only recently described as a cause of human infection. Immunosuppressed individuals are at risk for developing infections with opportunistic fungal pathogens, which are a major cause of morbidity and mortality in this population. In addition, the treatment of infections caused by these fungi is frequently challenging. We report a case of M. indicus subcutaneous infection in a 51‐year‐old man with human immunodeficiency virus and hepatitis C co‐infection, who had a liver transplant. He developed skin nodules with a sporotrichoid lymphangitic distribution. Histopathology demonstrated unusual fungal elements with angioinvasion. Mycology cultures isolated a dematiaceous mold with the characteristic curved hyaline conidia of M. indicus. Initial treatment involved a combination of amphotericin B lipid complex and voriconazole, followed by monotherapy with voriconazole. The subcutaneous lesions resolved completely after 4 months of antifungal therapy.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>17944811</pmid><doi>10.1111/j.1399-3062.2007.00278.x</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 1398-2273 |
| ispartof | Transplant infectious disease, 2008-06, Vol.10 (3), p.218-220 |
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| language | eng |
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| source | MEDLINE; Wiley Journals |
| subjects | amphotericin B lipid complex Antifungal Agents - therapeutic use Dermatomycoses - drug therapy Dermatomycoses - etiology hepatitis C HIV Humans liver transplant Liver Transplantation - adverse effects Male Middle Aged Mitosporic Fungi Mycoleptodiscus indicus voriconazole |
| title | A case of subcutaneous Mycoleptodiscus indicus infection in a liver transplant recipient successfully treated with antifungal therapy |
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